Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > IBNís New Ultrasensitive Electronic Sensor Array Speeds Up DNA Detection: Cost-effective technology has impact on disease diagnosis and biological research

IBNís Nanogap Sensor Array wafer chip can detect DNA rapidly and cost effectively.
IBNís Nanogap Sensor Array wafer chip can detect DNA rapidly and cost effectively.

Abstract:
Scientists at Singapore's Institute of Bioengineering and Nanotechnology (IBN), the world's first bioengineering and nanotechnology research institute, have successfully developed a novel electronic sensor array for more rapid, accurate and cost-efficient testing of DNA for disease diagnosis and biological research. This study was published recently in a leading international chemistry journal, Journal of the American Chemical Society 1.

IBNís New Ultrasensitive Electronic Sensor Array Speeds Up DNA Detection: Cost-effective technology has impact on disease diagnosis and biological research

Singapore | Posted on August 26th, 2009

Conventionally, human DNA is detected through the use of polymerase chain reaction (PCR), which while effective, is also expensive, cumbersome and time-consuming for widespread use. The PCR technique amplifies a single piece of DNA across several orders of magnitude, duplicating millions or more copies of a particular DNA sequence, in order to detect the genetic material more easily. Although effective, tests involving PCR may not be optimal for situations such as a pandemic outbreak, where results are needed quickly because PCR devices tend to be bulky and costly.

Called the "Nanogap Sensor Array", IBN's newly developed device has a unique, vertically aligned nanostructure design and a two-surface configuration based on electronic transduction. The sensor comes with a pair of micro-sized metal electrodes separated by a nanogap (5 - 20 nm or approximately 1/50,000 the width of a human hair). The biosensor will translate the presence of DNA into an electrical signal for computer analysis. The distinctively designed sensor chip has the ability to detect DNA more efficiently by "sandwiching" the DNA strands between the two different surfaces. Based on laboratory results, the sensor has shown "excellent" sensitivity at detecting trace amounts of DNA.

"By saving time and lowering expenses, our newly developed Nanogap Sensor Array offers a scalable and viable alternative for DNA testing. The novel vertical nanostructure design and two different surfaces of the sensor allow ultrasensitive detection of DNA. This sensitivity is best-in-class among electrical DNA biosensors. The design of the sensor also took into consideration the feasibility of mass production in a cost-effective way for expanded usage," said Dr Zhiqiang Gao, IBN Group Leader.

Another distinctive feature of the biosensor is its ability to capture DNA strands more effectively. This is possible because the two surfaces of the sensor are coated with a chemically treated "capture probe" solution through an electrochemical technique specially developed by IBN. This allows DNA strands to "stick" more easily to the sensor, resulting in a faster and more accurate analysis.

"This new biosensor holds significant promise to speed up on-going efforts in the detection and diagnosis of debilitating diseases such as cancer, cardiovascular problems and infectious viruses. We aim to make healthcare accessible to the masses with early disease diagnosis as the critical driving force behind the research we undertake here at IBN," added Professor Jackie Y. Ying, IBN Executive Director.

1 S. Roy, X. J. Chen, M.-H. Li, Y. F. Peng, F. Anariba and Z. Q. Gao, Journal of the American Chemical Society, (2009) DOI: 10.1021/JA901704T.

####

About Institute of Bioengineering and Nanotechnology
The Institute of Bioengineering and Nanotechnology (IBN) was established in 2003 as a national research institute under the Agency for Science, Technology and Research, Singapore, by Executive Director, Professor Jackie Yi-Ru Ying. Prof. Ying was a Professor of Chemical Engineering at the Massachusetts Institute of Technology (1992Ė2005). In 2008, Professor Ying was recognized as one of "One Hundred Engineers of the Modern Era" by the American Institute of Chemical Engineers for her groundbreaking work on nanostructured systems, nanoporous materials and host matrices for quantum dots and wires. Under her direction, IBN conducts research at the cutting-edge of bioengineering and nanotechnology. IBNís research programs are geared towards linking multiple disciplines across engineering, science and medicine to produce research breakthroughs that will improve healthcare and our quality of life.

IBN's research activities are focused in the following areas:

*

Drug and Gene Delivery, where the controlled release of therapeutics involve the use of functionalized polymers, hydrogels and biologics for targeting diseased cells and organs, and for responding to specific biological stimuli.
*

Cell and Tissue Engineering, where biomimicking materials, stem cell technology, microfluidic systems and bioimaging tools are combined to develop novel approaches to regenerative medicine and artificial organs.
*

Biosensors and Biodevices, which involve nanotechnology and microfabricated platforms for high-throughput biomarkers screening, automated biologics synthesis, and rapid disease diagnosis.
*

Pharmaceuticals Synthesis and Nanobiotechnology, which encompasses the efficient catalytic synthesis of chiral pharmaceuticals, and new nanocomposite materials for sustainable technology and alternative energy generation.

IBN's innovative research is aimed at creating new knowledge and intellectual properties in the emerging fields of bioengineering and nanotechnology to attract top-notch researchers and business partners to Singapore. Since 2003, IBN researchers have published a total of 502 papers. IBN also plays an active role in technology transfer and spinning off companies, linking the research institute and industrial partners to other global institutions. As of June 2009, IBN has filed 714 patent applications on its inventions and the Institute is currently looking for partners for collaboration and commercialization of its portfolio of technologies. IBN's current staff strength stands at ~ 180 scientists, engineers and medical doctors. With its multinational and multidisciplinary research staff, the institute is geared towards generating new biomaterials, devices, systems, equipment and processes to boost Singaporeís economy in the fast-growing biomedical sector.

IBN is also committed to nurturing young minds, and the institute acts as a training ground for PhD students and undergraduates. In October 2003, IBN initiated a Youth Research Program to open its doors to university students, as well as students and teachers from various secondary schools and junior colleges. It has since reached out to more than 31,075 students and teachers from 205 local and overseas schools and institutions.

For more information, please click here

Contacts:
Elena Tan
+65 6824 7032



Nidyah Sani
+65 6824 700

Copyright © Institute of Bioengineering and Nanotechnology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Smallest possible diamonds form ultra-thin nanothreads: Diamond nanothreads are likely to have extraordinary properties, including strength and stiffness greater than that of today's strongest nanotubes and polymers September 22nd, 2014

Engineers show light can play seesaw at the nanoscale: Discovery is another step toward faster and more energy-efficient optical devices for computation and communication September 22nd, 2014

New chip promising for tumor-targeting research September 22nd, 2014

Twisted graphene chills out: When two sheets of graphene are stacked in a special way, it is possible to cool down the graphene with a laser instead of heating it up, University of Manchester researchers have shown September 22nd, 2014

Nanomedicine

Engineered proteins stick like glue ó even in water: New adhesives based on mussel proteins could be useful for naval or medical applications September 22nd, 2014

New chip promising for tumor-targeting research September 22nd, 2014

Arrowhead to Present at BioCentury's NewsMakers in the Biotech Industry Conference September 19th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

Sensors

IEEE International Electron Devices Meeting To Celebrate 60th Anniversary as The Leading Technical Conference for Advanced Semiconductor Devices September 18th, 2014

Biosensors Get a Boost from Graphene Partnership: $5 Million Investment Supports Dozens of Jobs and Development of 300mm Fabrication Process and Wafer Transfer Facility September 18th, 2014

The Pocket Project will develop a low-cost and accurate point-of-care test to diagnose Tuberculosis: ICN2 holds a follow-up meeting of the Project on September 18th - 19th September 18th, 2014

Nanoscience makes your wine better September 17th, 2014

Announcements

Engineers show light can play seesaw at the nanoscale: Discovery is another step toward faster and more energy-efficient optical devices for computation and communication September 22nd, 2014

New chip promising for tumor-targeting research September 22nd, 2014

Twisted graphene chills out: When two sheets of graphene are stacked in a special way, it is possible to cool down the graphene with a laser instead of heating it up, University of Manchester researchers have shown September 22nd, 2014

New star-shaped molecule breakthrough: Scientists at The University of Manchester have generated a new star-shaped molecule made up of interlocking rings, which is the most complex of its kind ever created September 22nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE