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Home > News > Methylation Test May Aid Colon Cancer Diagnosis

August 18th, 2009

Methylation Test May Aid Colon Cancer Diagnosis

Abstract:
An investigational test for DNA methylation may help improve diagnosis of methylation-associated cancers, researchers reported.

The test detected methylation in 59% of blood samples from patients with colon cancer, a fourfold improvement over assays for carcinoembryonic antigen (CEA), Sanford D. Markowitz, MD, PhD, of Case Western Reserve University in Cleveland, and colleagues reported online in Nature Biotechnology.

The detection rate is comparable to that of mammography for breast cancer.

They performed PCR amplification of individual DNA fragments covalently linked to magnetic beads suspended in water-based nanoparticles immersed in oil droplets.

The beads contained a DNA sequence specific for exon 1 of the vimentin gene, which is hypermethylated in colon cancer. Following PCR amplification, the beads were hybridized by means of fluorescent probes specific to the state of methylation and then sorted and analyzed by flow cytometry.

Source:
medpagetoday.com

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