- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
August 18th, 2009
An investigational test for DNA methylation may help improve diagnosis of methylation-associated cancers, researchers reported.
The test detected methylation in 59% of blood samples from patients with colon cancer, a fourfold improvement over assays for carcinoembryonic antigen (CEA), Sanford D. Markowitz, MD, PhD, of Case Western Reserve University in Cleveland, and colleagues reported online in Nature Biotechnology.
The detection rate is comparable to that of mammography for breast cancer.
They performed PCR amplification of individual DNA fragments covalently linked to magnetic beads suspended in water-based nanoparticles immersed in oil droplets.
The beads contained a DNA sequence specific for exon 1 of the vimentin gene, which is hypermethylated in colon cancer. Following PCR amplification, the beads were hybridized by means of fluorescent probes specific to the state of methylation and then sorted and analyzed by flow cytometry.
|Related News Press|
News and information
Healthcare Nanotechnology (Nanomedicine) Market Size To 2020 June 5th, 2015
Chivalrous Knight Does Pro Bono June 27th, 2015
Newly-Developed Biosensor in Iran Detects Cocaine Addiction June 23rd, 2015
Researchers first to show that Saharan silver ants can control electromagnetic waves over an extremely broad range of the electromagnetic spectrum—findings may lead to biologically inspired coatings for passive radiative cooling of objects June 19th, 2015
Cellulose from wood can be printed in 3-D June 17th, 2015