Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > News > Methylation Test May Aid Colon Cancer Diagnosis

August 18th, 2009

Methylation Test May Aid Colon Cancer Diagnosis

Abstract:
An investigational test for DNA methylation may help improve diagnosis of methylation-associated cancers, researchers reported.

The test detected methylation in 59% of blood samples from patients with colon cancer, a fourfold improvement over assays for carcinoembryonic antigen (CEA), Sanford D. Markowitz, MD, PhD, of Case Western Reserve University in Cleveland, and colleagues reported online in Nature Biotechnology.

The detection rate is comparable to that of mammography for breast cancer.

They performed PCR amplification of individual DNA fragments covalently linked to magnetic beads suspended in water-based nanoparticles immersed in oil droplets.

The beads contained a DNA sequence specific for exon 1 of the vimentin gene, which is hypermethylated in colon cancer. Following PCR amplification, the beads were hybridized by means of fluorescent probes specific to the state of methylation and then sorted and analyzed by flow cytometry.

Source:
medpagetoday.com

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New technique for exploring structural dynamics of nanoworld: Developed in a Nobel laureate's laboratory at Caltech, hybrid approach allows ultrafast EM analysis of materials, showing tiny electronic changes in individual atoms within a material on ultrafast time scales April 28th, 2015

When mediated by superconductivity, light pushes matter million times more April 28th, 2015

Chemists strike nano-gold: 4 new atomic structures for gold nanoparticle clusters: Research builds upon work by Nobel Prize-winning team from Stanford University April 28th, 2015

Self-assembling biomaterial forms nanostructure templates for human tissue formation April 27th, 2015

Possible Futures

Printing Silicon on Paper, with Lasers April 21st, 2015

A glass fiber that brings light to a standstill: By coupling photons to atoms, light in a glass fiber can be slowed down to the speed of an express train; for a short while it can even be brought to a complete stop April 9th, 2015

Nanotechnology in Medical Devices Market is expected to reach $8.5 Billion by 2019 March 25th, 2015

Nanotechnology Enabled Drug Delivery to Influence Future Diagnosis and Treatments of Diseases March 21st, 2015

Nanomedicine

Chemists strike nano-gold: 4 new atomic structures for gold nanoparticle clusters: Research builds upon work by Nobel Prize-winning team from Stanford University April 28th, 2015

Self-assembling biomaterial forms nanostructure templates for human tissue formation April 27th, 2015

International research team discovers new mechanism behind malaria progression: Findings provide a new avenue for research in malaria treatment April 27th, 2015

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

Announcements

New technique for exploring structural dynamics of nanoworld: Developed in a Nobel laureate's laboratory at Caltech, hybrid approach allows ultrafast EM analysis of materials, showing tiny electronic changes in individual atoms within a material on ultrafast time scales April 28th, 2015

When mediated by superconductivity, light pushes matter million times more April 28th, 2015

Chemists strike nano-gold: 4 new atomic structures for gold nanoparticle clusters: Research builds upon work by Nobel Prize-winning team from Stanford University April 28th, 2015

Sensor Designed in Iran Able to Remove Formaldehyde Gas from Environment April 27th, 2015

Nanobiotechnology

Self-assembling biomaterial forms nanostructure templates for human tissue formation April 27th, 2015

Scientists join forces to reveal the mass and shape of single molecules April 27th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Scientists Use Nanoscale Building Blocks and DNA 'Glue' to Shape 3D Superlattices: New approach to designing ordered composite materials for possible energy applications April 23rd, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project