Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Secrets of the sandcastle worm could yield a powerful medical adhesive

The sandcastle worm makes a protective home out of beads of zirconium oxide in a lab. At the University of Utah, scientists have created a synthetic version of this glue for possible use in repairing fractured bones.

Credit: Fred Hayes
The sandcastle worm makes a protective home out of beads of zirconium oxide in a lab. At the University of Utah, scientists have created a synthetic version of this glue for possible use in repairing fractured bones.

Credit: Fred Hayes

Abstract:
Scientists have copied the natural glue secreted by a tiny sea creature called the sandcastle worm in an effort to develop a long-sought medical adhesive needed to repair bones shattered in battlefield injuries, car crashes and other accidents. They reported on the adhesive here today at the 238th National Meeting of the American Chemical Society (ACS).

Secrets of the sandcastle worm could yield a powerful medical adhesive

Washington, DC | Posted on August 17th, 2009

"This synthetic glue is based on complex coacervates, an ideal but so far unexploited platform for making injectable adhesives," says Russell Stewart, Ph.D. "The idea of using natural adhesives in medicine is an old one dating back to the first investigations of mussel adhesives in the 1980s. Yet almost 30 years later there are no adhesives based on

The traditional method of repairing shattered bones is to use mechanical connectors like nails, pins and metal screws for support until they can bear weight. But achieving and maintaining alignment of small bone fragments using screws and wires is challenging, Stewart said. For precise reconstruction of small bones, health officials have acknowledged that a biocompatible, biodegradable adhesive could be valuable because it would reduce metal hardware in the body while maintaining proper alignment of fractures.

Stewart and colleagues duplicated the glue that sandcastle worms (Phragmatopoma californica) use while building their homes in intertidal surf by sticking together bits of sand and broken sea shells. The inch-long marine worm had to overcome several adhesive challenges in order to glue together its underwater house, and its ingenuity has served as a recipe for Stewart's research team in developing the synthetic adhesive.

Stewart's challenge was to devise a water-based adhesive that remained insoluble in wet environments and was able to bond to wet objects. The team also concentrated on key details of the natural adhesive solidification process — a poorly timed hardening of the glue would make it useless, Stewart said. They learned the natural glue sets in response to changes in pH, a mechanism that was copied into the synthetic glue.

The new glue, says Stewart, a bioengineer at the University of Utah in Salt Lake City, has passed toxicity studies in cell culture. It is at least as strong as Super Glue and is twice as strong as the natural adhesive it mimics, he notes.

"We recognized that the mechanism used by the sandcastle worm is really a perfect vehicle for producing an underwater adhesive," Stewart said. "This glue, just like the worm's glue, is a fluid material that, although it doesn't mix with water, is water soluble."

Stewart has begun pilot studies focused on delivering bioactive molecules in the adhesive that could allow it to fix bone fragments and deliver medicines to the fracture site, such as antibiotics, pain relievers or compounds that might accelerate healing.

"We are very optimistic about this synthetic glue," he said. "Biocompatibility is one of the major challenges of creating an adhesive like this. Anytime you put something synthetic into the body, there's a chance the body will respond to it and damage the surrounding tissue. That's something we will monitor, but we've seen no indication right now that it will be a problem."

####

About American Chemical Society
The American Chemical Society is a nonprofit organization chartered by the U.S. Congress. With more than 154,000 members, ACS is the world's largest scientific society and a global leader in providing access to chemistry-related research through its multiple databases, peer-reviewed journals and scientific conferences. Its main offices are in Washington, D.C., and Columbus, Ohio.

For more information, please click here

Contacts:
Michael Bernstein

202-872-6042

Copyright © American Chemical Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Video - Watch a narrated video of the sandcastle worm building a home in a lab using bits of silicon.

Video - Russell Stewart's adhesive glues together submerged pieces of bone. Watch a narrated video of the adhesive at work.

Related News Press

News and information

MRI, on a molecular scale: Researchers develop system that could one day peer into the atomic structure of individual molecules April 20th, 2014

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Videos/Movies

Tiny particles could help verify goods: Chemical engineers hope smartphone-readable microparticles could crack down on counterfeiting April 15th, 2014

Biologists Develop Nanosensors to Visualize Movements and Distribution of Plant Stress Hormone April 15th, 2014

Director Wally Pfister joins UC Berkeley neuroengineers to discuss the science behind ‘Transcendence’ April 7th, 2014

KEEP CALM and PUBLISH PAPERS – a new video blog with graphic tutorials to scientific publishing April 7th, 2014

Discoveries

MRI, on a molecular scale: Researchers develop system that could one day peer into the atomic structure of individual molecules April 20th, 2014

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

'Exotic' material is like a switch when super thin April 18th, 2014

Materials/Metamaterials

Thinnest feasible membrane produced April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Engineers develop new materials for hydrogen storage April 15th, 2014

Industrial Nanotech, Inc. Lands First Major Order from Pemex, Mexico’s State-Owned Oil and Gas Company April 14th, 2014

Announcements

MRI, on a molecular scale: Researchers develop system that could one day peer into the atomic structure of individual molecules April 20th, 2014

Iranian Researchers Present New Model to Strengthen Superconductivity at Higher Temperatures April 19th, 2014

Iranian Researchers Produce New Anti-Cancer Drug from Turmeric April 19th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE