Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Multi-Laboratory Study Sizes Up Nanoparticle Sizing

Abstract:
As a result of a major inter-laboratory study, the standards body ASTM International has been able to update its guidelines for a commonly used technique for measuring the size of nanoparticles in solutions.

Multi-Laboratory Study Sizes Up Nanoparticle Sizing

Gaithersburg, MD | Posted on August 12th, 2009

The study, which was organized principally by researchers from the National Institute of Standards and Technology (NIST) and the Nanotechnology Characterization Laboratory of the National Cancer Institute, enabled updated guidelines that now include statistically evaluated data on the measurement precisions achieved by a wide variety of laboratories applying the ASTM guide.

Data from the inter-laboratory comparison gathered from 26 different laboratories will provide a valuable benchmark for labs measuring the sizes and size distribution of nanoparticles suspended in fluids—one of the key measurements in nanotechnology research, especially for biological applications, according to materials researcher Vince Hackley, who led the NIST portion of the study.

Size is an important characteristic of nanoparticles in a variety of potential uses, but particularly in biotech applications where they are being studied for possible use in cancer therapies. The size of a nanoparticle can significantly affect how cells respond to it. (See, for example "Study: Cells Selectively Absorb Short Nanotubes," NIST Tech Beat, March 30, 2007.)

One widely used method for rapidly measuring the size profile of nanoparticles in, say, a buffer solution, is photon correlation spectroscopy (PCS), sometimes called "dynamic light scattering." The technique is powerful but tricky. The basic idea is to pass a laser beam through the solution and then to measure how rapidly the scattered light is fluctuating—faster moving particles cause the light scattering to change more rapidly than slower moving particles. If you know that, plus several basic parameters such as the viscosity and temperature of the fluid, says Hackley, and you can control a number of potential sources of error, then you can calculate meaningful size values for the particles.

ASTM standard E2490 is a guide for doing just that. The goal of the ASTM-sponsored study was to evaluate just how well a typical lab could expect to measure particle size following the guide. "The study really assesses, in a sense, how well people can apply these techniques given a fairly well-defined protocol and a well-defined material," explains Hackley. Having a "well-defined material" was a key factor, and one thing that made the experiment possible was the release this past year of NIST's first nanoparticle reference standards for the biomedical research community—NIST-certified solutions of gold nanoparticles of three different diameters, a project also supported by NCL. (See "NIST Reference Materials Are 'Gold Standard' for Bio-Nanotech Research, " NIST Tech Beat, Jan. 8, 2008.)

The inter-laboratory study required participating labs to measure particle size distribution in five samples—the three NIST reference materials and two solutions of dendrimers, a class of organic molecules that can be synthesized within a very narrow size range. The labs used not only PCS, but also electron and atomic force microscopy. The results were factored into precision and bias tables that are now a part of the ASTM standard.

For more on the study and ASTM standard E2490, see the ASTM International release "Extensive Interlaboratory Study Incorporated into Revision of ASTM Nanotechnology Standard."

####

About NIST
From automated teller machines and atomic clocks to mammograms and semiconductors, innumerable products and services rely in some way on technology, measurement, and standards provided by the National Institute of Standards and Technology.

Founded in 1901, NIST is a non-regulatory federal agency within the U.S. Department of Commerce. NIST's mission is to promote U.S. innovation and industrial competitiveness by advancing measurement science, standards, and technology in ways that enhance economic security and improve our quality of life.

For more information, please click here

Contacts:
Media Contact
Michael Baum

(301) 975-2763

Copyright © NIST

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Brookhaven Lab Launches Computational Science Initiative:Leveraging computational science expertise and investments across the Laboratory to tackle "big data" challenges October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

NIST offers electronics industry 2 ways to snoop on self-organizing molecules October 22nd, 2014

Nanotubes/Buckyballs

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Beyond LEDs: Brighter, new energy-saving flat panel lights based on carbon nanotubes - Planar light source using a phosphor screen with highly crystalline single-walled carbon nanotubes (SWCNTs) as field emitters demonstrates its potential for energy-efficient lighting device October 14th, 2014

Nanomedicine

Sopping up proteins with thermosponges: Researchers develop novel nanoparticle platform that proves effective in delivering protein-based drugs October 22nd, 2014

Bipolar Disorder Discovery at the Nano Level: Tiny structures found in brain synapses help scientists better understand disorder October 22nd, 2014

Journal Nanotechnology Progress International (JONPI), 2014, Volume 5, Issue 1, pp 1-24 October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Materials/Metamaterials

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Super stable garnet ceramics may be ideal for high-energy lithium batteries October 21st, 2014

Could I squeeze by you? Ames Laboratory scientists model molecular movement within narrow channels of mesoporous nanoparticles October 21st, 2014

Announcements

NanoTechnology for Defense (NT4D) October 22nd, 2014

Mechanism behind nature's sparkles revealed October 22nd, 2014

TARA Biosystems and Harris & Harris Group Form Company to Improve Safety and Efficacy of New Therapies October 22nd, 2014

Researchers patent a nanofluid that improves heat conductivity October 22nd, 2014

Nanobiotechnology

Mechanism behind nature's sparkles revealed October 22nd, 2014

‘Designer’ nanodevice could improve treatment options for cancer sufferers October 22nd, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Scientists Map Key Moment in Assembly of DNA-Splitting Molecular Machine: Crucial steps and surprising structures revealed in the genesis of the enzyme that divides the DNA double helix during cell replication October 15th, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE