Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoscale origami from DNA - Researchers develop a new toolbox for nano-engineering

DNA molecules as ideal building blocks for nano structures. Image: H. Dietz, TUM Dept. of Physics
DNA molecules as ideal building blocks for nano structures. Image: H. Dietz, TUM Dept. of Physics

Abstract:
Scientists at the Technische Universitaet Muenchen (TUM) and Harvard University have thrown the lid off a new toolbox for building nanoscale structures out of DNA, with complex twisting and curving shapes. In the August 7 issue of the journal Science, they report a series of experiments in which they folded DNA, origami-like, into three-dimensional objects including a beach ball-shaped wireframe capsule just 50 nanometers in diameter.

Nanoscale origami from DNA - Researchers develop a new toolbox for nano-engineering

Germany & Massachusetts | Posted on August 6th, 2009

"Our goal was to find out whether we could program DNA to assemble into shapes that exhibit custom curvature or twist, with features just a few nanometers wide," says biophysicist Hendrik Dietz, a professor at the Technische Universitaet Muenchen. Dietz's collaborators in these experiments were Professor William Shih and Dr. Shawn Douglas of Harvard University. "It worked," he says, "and we can now build a diversity of three-dimensional nanoscale machine parts, such as round gears or curved tubes or capsules. Assembling those parts into bigger, more complex and functional devices should be possible."

As a medium for nanoscale engineering, DNA has the dual advantages of being a smart material - not only tough and flexible but also programmable - and being very well characterized by decades of study. Basic tools that Dietz, Douglas, and Shih employ are programmable self-assembly - directing DNA strands to form custom-shaped bundles of cross-linked double helices - and targeted insertions or deletions of base pairs that can give such bundles a desired twist or curve. Right-handed or left-handed twisting can be specified. They report achieving precise, quantitative control of these shapes, with a radius of curvature as tight as 6 nanometers.

The toolbox they have developed includes a graphical software program that helps to translate specific design concepts into the DNA programming required to realize them. Three-dimensional shapes are produced by "tuning" the number, arrangement, and lengths of helices.

In their current paper, the researchers present a wide variety of nanoscale structures and describe in detail how they designed, formed, and verified them. "Many advanced macroscopic machines require curiously shaped parts in order to function," Dietz says, "and we have the tools to make them. But we currently cannot build something intricate such as an ant's leg or, much smaller, a ten-nanometer-small chemical plant such as a protein enzyme. We expect many benefits if only we could build super-miniaturized devices on the nanoscale using materials that work robustly in the cells of our bodies - biomolecules such as DNA."

Original paper:

Folding DNA into Twisted and Curved Nanoscale Shapes
Hendrik Dietz, Shawn M. Douglas, and William M. Shih,
Science 7 August 2009: Vol. 325. no. 5941, pp. 725 - 730 - DOI: 10.1126/science.1174251

####

About Technische Universitaet Muenchen
Technische Universität München (TUM; sometimes translated as Technical University Munich)[2] is a research university with campuses in Munich, Garching, and Weihenstephan.

TUM is among the highest acclaimed universities in Germany, producing several Nobel Laureates including Gerhard Ertl who in 2007 received the Nobel Prize in Chemistry.

From Wikipedia, the free encyclopedia

For more information, please click here

Contacts:
Prof. Hendrik Dietz
Department of Physics
Technische Universitaet Muenchen
James-Franck-Str. 1, 85748 Garching, Germany
Tel. +49 89 289 12539
Fax: +49 89 289 12523

Copyright © Technische Universitaet Muenchen

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanomechanics, Inc. to Exhibit at the SEM Conference: Nanoindentation experts will attend and exhibit their instruments at the Conference and Exposition on Experimental and Applied Mechanics in Indianapolis May 25th, 2017

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Possible Futures

Nanomechanics, Inc. to Exhibit at the SEM Conference: Nanoindentation experts will attend and exhibit their instruments at the Conference and Exposition on Experimental and Applied Mechanics in Indianapolis May 25th, 2017

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Molecular Machines

First 3-D observation of nanomachines working inside cells: Researchers headed by IRB Barcelona combine genetic engineering, super-resolution microscopy and biocomputation to allow them to see in 3-D the protein machinery inside living cells January 27th, 2017

Micro-bubbles make big impact: Research team develops new ultrasound-powered actuator to develop micro robot November 25th, 2016

Scientists come up with light-driven motors to power nanorobots of the future: Researchers from Russia and Ukraine propose a nanosized motor controlled by a laser with potential applications across the natural sciences and medicine November 11th, 2016

HKU chemists develop world's first light-seeking synthetic Nanorobot November 9th, 2016

Announcements

Nanomechanics, Inc. to Exhibit at the SEM Conference: Nanoindentation experts will attend and exhibit their instruments at the Conference and Exposition on Experimental and Applied Mechanics in Indianapolis May 25th, 2017

Three-dimensional graphene: Experiment at BESSY II shows that optical properties are tuneable May 24th, 2017

Leti to Demo 1st Wireless UNB Transceiver for ‘Massive Internet of Things’ at RFIC 2017 and IMS 2017: Leti Will also Present Three Papers & Two Workshops on 5G Communications IC Design, from RF to mm-Wave, During IMS 2017 and RFIC 2017 in Hawaii May 24th, 2017

GLOBALFOUNDRIES and Chengdu Partner to Expand FD-SOI Ecosystem in China: More than $100M investment to establish a center of excellence for FDXTM FD-SOI design May 23rd, 2017

Nanobiotechnology

Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling May 22nd, 2017

Sensors detect disease markers in breath May 19th, 2017

Oddball enzyme provides easy path to synthetic biomaterials May 17th, 2017

The brighter side of twisted polymers: Conjugated polymers designed with a twist produce tiny, brightly fluorescent particles with broad applications May 16th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project