Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > New Nanoparticles Could Revolutionize Therapeutic Drug Discovery

Abstract:
Understanding the structure of proteins is a vital first step in developing new drugs, but to date, researchers have had difficulty studying the large number of proteins that are normally embedded in the cell membrane, a family of proteins that includes those involved in cancer-related signaling processes. However, using nanoparticles, scientists from the University of Birmingham in the United Kingdom have found a way to preserve membrane proteins intact, enabling detailed analysis of their structure, molecular functions, and interaction with potential anticancer agents.

New Nanoparticles Could Revolutionize Therapeutic Drug Discovery

Bethesda, MD | Posted on July 21st, 2009

Michael Overduin, Ph.D., who led the study that was published in the Journal of the American Chemical Society, explained: "We have shown how a polymer can wrap around and preserve membrane proteins intact in stable nanoparticles. Membrane proteins are the most valuable but technically challenging targets for drug discovery. Finding a gentle solution that preserves their structure and activity, yet is robust enough for experimental interrogation, has eluded scientists for decades, but is now available."

The key to stabilizing membrane proteins turns out to be a polymer made of styrene and maleic acid. This copolymer is able to envelope membrane proteins in an environment that closely mimics that of the cell membrane while simultaneously forming stable nanoparticles that the researchers call styrene maleic acid lipid particles (SMALPs). The investigators found that not only did the proteins maintain their folded structure and binding and enzyme activities in the SMALPs, but also using the nanoparticles allowed them to be used in virtually any type of laboratory analysis.

Timothy R. Dafforn, Ph.D., who jointly ran the study, noted: "In the past, studies have concentrated largely on soluble proteins since membrane proteins are so difficult to make. However, the discovery of the SMALPs removes this barrier and opens up access to membrane proteins. This has exciting clinical implications since it may enable drug discovery on receptors that are currently too difficult to produce or to study by current methods."

This work is detailed in the paper "Membrane proteins solubilized intact in lipid containing nanoparticles bounded by styrene maleic acid copolymer." An investigator from the University of Warwick, United Kingdom, also participated in this study. An abstract of the paper is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with todayís explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New method for making green LEDs enhances their efficiency and brightness July 30th, 2016

Scientists change properties of zeolites to improve hemodialysis July 29th, 2016

Novel state of matter: Observation of a quantum spin liquid July 29th, 2016

A new type of quantum bits July 29th, 2016

Possible Futures

New method for making green LEDs enhances their efficiency and brightness July 30th, 2016

Scientists change properties of zeolites to improve hemodialysis July 29th, 2016

Novel state of matter: Observation of a quantum spin liquid July 29th, 2016

A new type of quantum bits July 29th, 2016

Nanomedicine

Scientists change properties of zeolites to improve hemodialysis July 29th, 2016

Pixel-array quantum cascade detector paves the way for portable thermal imaging devices: Research team from TU-Wien Center for Micro- and Nanostructures have developed a new 'cooler' sensing instrument thereby increasing energy-efficiency and enhancing mobility for diagnostic tes July 28th, 2016

Starpharma initiates new DEPô drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Announcements

New method for making green LEDs enhances their efficiency and brightness July 30th, 2016

Scientists change properties of zeolites to improve hemodialysis July 29th, 2016

Novel state of matter: Observation of a quantum spin liquid July 29th, 2016

A new type of quantum bits July 29th, 2016

Nanobiotechnology

Scientists change properties of zeolites to improve hemodialysis July 29th, 2016

Starpharma initiates new DEPô drug delivery program with AstraZeneca July 27th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic