Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Implantable Device Offers Continuous Cancer Monitoring

Abstract:
Surgical removal of a tissue sample is now the standard for diagnosing cancer. Such procedures, known as biopsies, are accurate but offer only a snapshot of the tumor at a single moment in time.

Implantable Device Offers Continuous Cancer Monitoring

Bethesda, MD | Posted on July 21st, 2009

Monitoring a tumor for weeks or months after the biopsy and tracking its growth and how it responds to treatment would be much more valuable, says Michael J. Cima, Ph.D., who has developed the first implantable device that can do just that. Dr. Cima, professor of materials science and engineering at the Massachusetts Institute of Technology (MIT) and a member of the MIT-Harvard Center of Cancer Nanotechnology Excellence (CCNE), and his colleagues reported in the journal Biosensors and Bioelectronics that their device successfully tracked a tumor marker in mice for 1 month. Fellow MIT CCNE investigators Robert Langer, Ph.D., Al Charest, Ph.D., M.Sc., and Ralph Weissleder, M.D., Ph.D., also contributed to this work.

Such implants could one day provide up-to-the-minute information about what a tumor is doing—whether it is growing or shrinking, how it is responding to treatment, and whether it has metastasized or is about to do so. "What this does is basically take the lab and put it in the patient," said Dr. Cima.

The devices, which could be implanted at the time of biopsy, also could be tailored to monitor chemotherapy agents, allowing doctors to determine whether cancer drugs are reaching the tumors. They also can be designed to measure acidity (pH) or oxygen levels, which reveal tumor metabolism and how it is responding to therapy.

The cylindrical, 5-millimeter implant is made of high-density polyethylene encased in a polycarbonate membrane with 10-nanometer-diameter pores. Magnetic nanoparticles coated with antibodies specific to the target molecules are loaded into the device. Target molecules enter the implant through the polycarbonate membrane, binding to the nanoparticles and causing them to clump together. That clumping can be detected by magnetic resonance imaging (MRI) because the aggregated nanoparticles produce a marked change in the MRI signal associated with the implanted device. The researchers observed measurable changes within 1 day of implantation.

In the published work, the investigators transplanted human tumors into test mice and then used the implants to track levels of human chorionic gonadotropin, a hormone produced by the human tumor cells. Dr. Cima said he believes an implant to test for pH levels could be commercially available in a few years, followed by devices to test for complex chemicals such as other hormones and drugs.

This work, which is detailed in the paper "Implantable diagnostic device for cancer monitoring," was supported by the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer. An abstract is available at the journal's Web site.

####

About NCI Alliance for Nanotechnology in Cancer
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Copyright © NCI Alliance for Nanotechnology in Cancer

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Possible Futures

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Nanomedicine

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

Announcements

Superheroes are real: Ultrasensitive nonlinear metamaterials for data transfer June 25th, 2016

Russian physicists create a high-precision 'quantum ruler': Physicists have devised a method for creating a special quantum entangled state June 25th, 2016

Nanoscientists develop the 'ultimate discovery tool': Rapid discovery power is similar to what gene chips offer biology June 25th, 2016

Ultrathin, flat lens resolves chirality and color: Multifunctional lens could replace bulky, expensive machines June 25th, 2016

Nanobiotechnology

Nanotechnology and math deliver two-in-one punch for cancer therapy resistance June 24th, 2016

Tailored DNA shifts electrons into the 'fast lane': DNA nanowire improved by altering sequences June 22nd, 2016

Self-assembling icosahedral protein designed: Self-assembling icosahedral protein designed June 22nd, 2016

Stealth nanocapsules kill Chagas parasites in mouse models June 22nd, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic