Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Researchers enlist DNA to bring carbon nanotubes' promise closer to reality: Tailored sequences of DNA lead to breakthrough in the campaign to sort and separate CNTs

Abstract:
A team of researchers from DuPont and Lehigh University has reported a breakthrough in the quest to produce carbon nanotubes (CNTs) that are suitable for use in electronics, medicine and other applications.

Researchers enlist DNA to bring carbon nanotubes' promise closer to reality: Tailored sequences of DNA lead to breakthrough in the campaign to sort and separate CNTs

Bethlehem, PA | Posted on July 12th, 2009

In an article published in the July 9 issue of Nature, the group says it has developed a DNA-based method that sorts and separates specific types of CNTs from a mixture.

CNTs are long, narrow cylinders of graphite with a broad range of electronic, thermal and structural properties that vary according to the tubes' shape and structure. This versatility gives CNTs great promise in electronics, lasers, sensors and biomedicine, and as strengthening elements in composite materials.

Current methods of producing CNTs yield mixtures of tubes with different diameters and symmetry, or "chirality." Before the tubes can be used, however, they must be disentangled from a mixture and "purified" into separate species of CNTs of the same electronic type.

"A systematic method of purifying every single-chirality species of the same electronic type from a synthetic mixture of single-walled nanotubes is highly desirable," the DuPont-Lehigh group wrote in Nature, "but the task has proven to be insurmountable to date."

The Nature article is titled "DNA sequence motifs for structure-specific recognition and separation of carbon nanotubes." Its authors are Ming Zheng, Xiaomin Tu, Anand Jagota and Suresh Manohar. Zheng and Tu are scientists with DuPont Central Research and Development. Jagota is a professor of chemical engineering at Lehigh. Manohar is a graduate student in chemical engineering at Lehigh.

In 2003, a team of scientists from DuPont, MIT and the University of Illinois at Urbana-Champaign developed a new method of separating metallic CNTs from semiconducting CNTs using single-stranded DNA and anion-exchange chromatography. The scientists reported their discovery in Science.

The new results improve on the 2003 results by identifying more than 20 DNA short sequences that can recognize individual types, or species, of carbon nanotubes and purify them from a mixture.

The new method utilizes tailored DNA sequences and "allows the purification of all 12 major single-chirality semiconducting species from a synthetic mixture, with sufficient yield for both fundamental studies and application development."

The current experiments were conducted at DuPont by Tu and Zheng, while Manohar and Jagota developed structural models using molecular simulations.

"The interesting discovery made by Tu and Zheng," says Jagota, "is that if you choose the DNA sequence correctly, it recognizes a particular type of CNT and enables us to sort that variety cleanly. This kind of practical improvement brings us closer to manufacturing possibility."

How does DNA recognize and sort types of CNTs? The DuPont-Lehigh team says this could be related to DNA's ability to form a structure different from its usual double helix when wrapping around the CNTs.

An alpha helix, like scotch tape wrapped around a pencil to form a tube, is a common shape seen in proteins, one of the main classes of biological molecules. Another common structure seen in proteins is the beta sheet. If you take a long strand in your palm, stretch it out to the tip of your index finger, loop it to your middle finger, then back to your palm, then out to your ring finger, back to your palm and out to your little finger, you form a type of beta sheet.

"Such a structure is not known for DNA," says Jagota, "but we've shown that it is possible as long as you allow the DNA to adsorb on a surface. If the surface is cylindrical, like a CNT, you get a variant called the beta-barrel."

While the researchers do not have absolute proof, they say circumstantial evidence strongly supports their hypothesis that the DNA is forming this well-organized structure and that it recognizes a specific CNT in the same way that biological molecules recognize each other by structure.

Jagota, who directs Lehigh's bioengineering program, says the biomedical ramifications of the researchers' discovery are particularly exciting. One potential application for CNTs, for example, is to use them as substrates that can deliver biological molecules to cells in the body.

"We are very interested in the biomedical applications of this work," says Jagota. "What does this say about how DNA interacts with nanomaterials? Will they be harmful inside the body? Can we take advantage of the interaction for therapeutic applications? It's a big open field."

####

About Lehigh University
Lehigh’s picturesque 1600-acre wooded campus is actually built into the side of what is affectionately known as "Old South Mountain" in historic Bethlehem, Pa. A little more than an hour’s car ride from Philadelphia or New York City, Lehigh is located within the thriving economic and cultural corridor of the eastern United States.

For more information, please click here

Contacts:
Kurt Pfitzer

610-758-3017

Copyright © Lehigh University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanosafety research – there’s room for improvement October 29th, 2014

Nanotubes/Buckyballs

Tiny carbon nanotube pores make big impact October 29th, 2014

Materials for the next generation of electronics and photovoltaics: MacArthur Fellow develops new uses for carbon nanotubes October 21st, 2014

Special UO microscope captures defects in nanotubes: University of Oregon chemists provide a detailed view of traps that disrupt energy flow, possibly pointing toward improved charge-carrying devices October 21st, 2014

Imaging electric charge propagating along microbial nanowires October 20th, 2014

Discoveries

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanoparticles Display Ability to Improve Efficiency of Filters October 28th, 2014

Announcements

New solar power material converts 90 percent of captured light into heat: SunShot Project aims to make solar cost competitive October 29th, 2014

Tiny carbon nanotube pores make big impact October 29th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

Nanosafety research – there’s room for improvement October 29th, 2014

Nanobiotechnology

Tiny carbon nanotube pores make big impact October 29th, 2014

Molecular beacons shine light on how cells 'crawl' October 27th, 2014

Breakthrough in molecular electronics paves the way for DNA-based computer circuits in the future: DNA-based programmable circuits could be more sophisticated, cheaper and simpler to make October 27th, 2014

NYU Researchers Break Nano Barrier to Engineer the First Protein Microfiber October 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE