Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Remote-control closed system invented for inserting radio-active atoms inside fullerenes: The new material will increase control of radiation therapy

Lead rods, which are infused with the material to be encapsulated in hollow carbon molecules known as fullerenes, are blasted with a plasma arc. The resulting soot contains the filled carbon molecules. The remote-control process was invented to insert radio-labeled materials into fullerenes for use in diagnosing and treating tumors. Brain tumors are the target of the NIH-funded research being carried out by a Virginia Tech-Virginia Commonwealth University team.

Credit: Harry Dorn
Lead rods, which are infused with the material to be encapsulated in hollow carbon molecules known as fullerenes, are blasted with a plasma arc. The resulting soot contains the filled carbon molecules. The remote-control process was invented to insert radio-labeled materials into fullerenes for use in diagnosing and treating tumors. Brain tumors are the target of the NIH-funded research being carried out by a Virginia Tech-Virginia Commonwealth University team.

Credit: Harry Dorn

Abstract:
Virginia Tech chemistry Professor Harry C. Dorn, Emory and Henry College chemistry Professor James Duchamp, and Panos Fatouros, professor and chair of the Division of Radiation Physics and Biology at the Virginia Commonwealth University School of Medicine have co-invented a hands-off process for filling fullerenes with radio-active material.

Remote-control closed system invented for inserting radio-active atoms inside fullerenes: The new material will increase control of radiation therapy

Blacksburg, VA | Posted on July 7th, 2009

Fullerenes are hollow carbon molecules. Dorn has created new materials by filling them with atoms of various metals. An important example is a fullerene that encases a sensitive contrast agent (gadolinium) for MRI applications, including as a diagnostic and therapeutic agent for brain tumors. Dorn and Fatouros at VCU have funding from the National Institutes of Health's National Cancer Institute (NCI) to further develop, produce, and test fullerene nanoparticles that can identify brain tumor cells and selectively target them for radiation therapy.

What if the radioactive material could also be encased in a carbon cage? Dorn asked himself several years ago. With more funding from NCI and Virginia's Commonwealth Technology Research Fund (CTRF), he set out to do it.

Now Dorn and Duchamp have invented a generator that makes the new material by remote control. "The new materials come out the bottom like a beer product," Dorn said. The golden liquid is not dispensed into an open cup, of course.

Basically, rods about three times the size of a pencil lead that are made up of graphite and lutetium (Lu) are inserted into big jar through a tube on one side and moved slowly toward a source of electricity on the other side. The jolted rod burns dramatically and the inside of the jar is coated with ash. A nozzle kind of like a miniature carwash wand is lowered from the top to rinse the soot to the bottom and out through a filter. The soot is trapped and the resulting beer-colored solution contains Lu atoms bound to nitrogen inside of fullerenes. This radiolabeled nanomaterial is then further purified by passage through a column that traps the empty-cage fullerenes. The resulting liquid is evaporated and hydroxyl atoms are attached to the molecules so they will be soluble in biofluids.

All of the steps of the process are managed remotely and the purified product is decanted into a shielded container.

Dorn and Duchamp have used non-radioactive Lu to produce the trimetallic nitride endohedral metallofullerenes - in other words, three atoms of Lu attached to a nitrogen atom inside an 80-atom carbon molecule cage. Once the apparatus is at VCU, Fatouros will use isotope 177Lu, which is used to treat cancer. Although other details need to be worked out, Dorn is confident the generator will work just as well with the radiolabeled product and will produce

It all takes less than a day, which is important because 177Lu has a half life of six and one-half days. "So we can't take 30 days to make the product," said Duchamp.

It will be the first time that 177Lu has been encapsulated in a fullerene and the first time any radioactive metal has been encapsulated under remote control with direct purification to a pure product.

"The advantage of the metal cage is we can control where it goes biologically," Dorn said.

"We believe it will mean fewer side effects with better targeted localization, but that remains to be tested," said Fatouros.

"Another advantage is we can deliver other materials inside the fullerene with the 177Lu - such as a targeting agent (interleukin-13) and an MRI contrast agent," said Dorn.

Creation of such a multi-modality material for use on brain tumors is a specific goal of Fatouros and Dorn's NCI-funded research project, "Metallofullerene imaging and targeting of glioma." "The MRI agent lets you see where you are going and the 177Lu lets you treat an exact region," said Dorn. "The imaging ability also lets you see if the tumor is shrinking or getting larger."

An earlier stage of the research was presented at the NCI Alliance for Nanotechnology in Cancer Investigators Meeting in September 2008 and a patent application has been filed.

Dorn points out that the new device will also allow the production of other kinds of radio-labeled fullerenes that can be used for environmental studies, such as to track fullerene nanomaterials.

####

For more information, please click here

Contacts:
Susan Trulove

540-231-5646

Copyright © Virginia Tech

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

Read more about Fatouros and Dorn's National Institutes for Health funded research:

Dorn is director of the Carbonaceous Nanomaterials Center at Virginia Tech. Learn more here:

Related News Press

News and information

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

'Life Redesigned: The Emergence of Synthetic Biology' Lecture at Brookhaven Lab on Wednesday, April 30: Biomedical Engineer James Collins to Speak for BSA Distinguished Lecture Series April 16th, 2014

ECHA Planning Workshop on Regulatory Challenges in the Risk Assessment of Nanomaterials April 16th, 2014

Nanomedicine

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Nanobiotix Appoints Thierry Otin as Head of Manufacturing and Supply April 15th, 2014

PAM-XIAMEN Offers UV LED wafer April 15th, 2014

Discoveries

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

Scientists observe quantum superconductor-metal transition and superconducting glass: A team including MIPT physicist observed quantum superconductor-metal transition and superconducting glass April 16th, 2014

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Targeting cancer with a triple threat: MIT chemists design nanoparticles that can deliver three cancer drugs at a time April 15th, 2014

Announcements

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

Aerotech X-Y ball-screw stage for economical high performance Planar positioning April 16th, 2014

Energy Research Facility Construction Project at Brookhaven Lab Wins U.S. Energy Secretary's Achievement Award April 16th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE