Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Team Tracks Nanotube Cancer Killers in Live Tissue

Abstract:
Collaboration between scientists at medical school and nearby metropolitan campus in Arkansas detected, tracked and killed cancer cells in real time in living system with carbon nanotubes.

Team Tracks Nanotube Cancer Killers in Live Tissue

Little Rock, AR | Posted on May 20th, 2009

Nanotechnology scientists at two Arkansas research institutions have developed a method of detecting, tracking, and killing cancer cells in real time with carbon nanotubes.

The discovery opens the prospect of a new, major front in the fight to eradicate cancer with promise for a new generation of cancer treatment beyond surgery, radiation, and chemotherapy.

Dr. Alex Biris, University of Arkansas at Little Rock (UALR) chief scientist at the Nanotechnology Center and assistant professor of applied science in University's Donaghey College of Engineering and Information Technology, and Dr. Vladimir P. Zharov, professor and director of the Phillips Classic Laser and Nanomedicine Laboratories in the University of Arkansas for Medical Sciences (UAMS) Winthrop P. Rockefeller Cancer Institute, published their findings in the latest issue of the Journal of Biomedical Optics.

"Until now, nobody has been able to fully understand and study in vivo and in real time how these nanoparticles travel through a living system," Biris said. "By using Raman spectroscopy, we showed that it is possible not only to monitor and detect nanomaterials moving through the circulation, but also to detect single cancer cells tagged with carbon nanotubes. In this way, we can measure their clearance rate and their biodistribution kinetics through the lymph and blood systems."

Zharov emphasized that in vivo Raman flow cytometry is promising for the detection and identification of a broad spectrum of various nanoparticles with strong Raman scattering properties, such as cells, bacteria, and even viruses.

"Before any clinical application of nanoparticles, it is imperative to determine their pharmacological profiles," Zharov said. "And this tool will provide this function as a supplement or even an alternative to the existing methods."

In their research, Biris, Zharov, and UAMS colleague Ekaterina Galanzha, M.D., injected a single human cancer cell containing carbon nanotube material in the tail vein of a test rat. They were able to follow the circulation of the carbon nanotubes in the blood vessels to the rat's ear, tracking the cell through the rat's blood stream, lymphatic system, and tissue with a Raman spectrometer.

In the same issue of the scientific journal, Biris and Zharov published a second paper discussing how nanoparticles can tag cancer cells. A laser then heats the nanoparticles, killing the cancer cell.

"If we are able to target cancer cells using these nanomaterials, we can monitor where the cancer cells are specifically located, and then we can kill them," Biris said.

He said the live rat experiment shows how the cancer killing process leaves only a dead cell and nanoparticles that, within a matter of hours, disintegrate and die.

Dr. Mary Good, dean of UALR's Donaghey College of Engineering and Information Technology, said the medical and economic ramifications of the discovery are significant.

"The research Dr. Biris and Dr. Zharov have conducted indeed is significant and promising," said Good, former technology undersecretary of Commerce in the Clinton administration. "It points to a whole new direction for medical applications for nanoparticles. There still is extensive time needed for research into the ultimate utility for these approaches and for human subject experiments. But this early work is exciting and provides long-term hope for more effective cancer treatments."

Biris, 34, said the UALR Nanotechnology Center's aim is to accelerate the development of commercial applications of nanotechnology and its potential to revolutionize medical advancements and the next generation of manufacturing of other products.

"The close location of UALR with its cutting-edge analytical chemistry and nanotechnological tools, along with UAMS and its established biological and medical infrastructures, provides unique opportunities for comprehensive pre-clinical evaluation of nanotechnological products," Zharov said. "That allows for us to accelerate Nanotechnology advances from bench to bedside, providing breakthroughs in early diagnosis, prevention and effective treatment of cancers, stroke, heart attack, infections, and neurological disorders which remain the leading cause of death in the U.S."

About the scientists
Zharov obtained his Ph.D and DSc degrees at Moscow State Technical University and completed a postdoctoral fellowship at Lawrence National Laboratory of the University of California. He served as professor and chairman of the Biomedical Engineering Department at Moscow University. Since 2000, he is a professor and director of the Phillips Classic Laser and Nanomedicine Laboratories at the UAMS Winthrop P. Rockefeller Cancer Institute. Zharov has authored and co-authored five books, 40 patents, and published close to 200 papers. He is the principle investigator in 12 grants from the NIH, NSF, and DoD. He has unique interdisciplinary skills in physics, biology and medicine.

Zharov's research interests include the development and medical application of advanced laser, nanotechnology and imaging and he was the first recipient of the United States Maiman Award, named after the inventor of the first laser. His laboratories have pioneered laser-ultrasound microsurgery, phototherapy of post-mastectomy lymphedema, photoacoustic tweezers, multiplex imaging of cancer cells, laser-gene therapy, laser-based chemosensitivity and radiosensitivity tests, in vivo noninvasive photoacoustic cytometry and blood and lymph cancer tests. In particular, Zharov invented one of the first applications of nanotechnology for treating cancer and infections using laser-activated gold nanoparticles (U.S. Patent, 2000).

Recently, he was awarded by the $1.5 million five-year grant from the National Cancer Institute supporting one of the first clinical application of nanomedicine technology for early cancer diagnosis.

Biris earned his Ph.D. at UALR and joined the faculty in 2006. He and his team have filed 11 patent applications in nanotechnology, bio-nanotechnology, space exploration, and materials science areas. He is fully involved in studying the interaction of nanomaterials with biological systems and using use such novel nanostructures for targeting and killing cancer cells. He has more than 160 papers published in peer reviewed journals or presented at international conferences.

He was part of the team that designed and developed a newly patented electrodynamic screen for space exploration in collaboration with NASA. Patent applications are pending on his new method and technology for producing large quantities of carbon nanotubes with high purity. He led the design and development of carbon nanostructures-based filters to efficiently remove bio-chemical contaminants from air and water.

Biris also developed a unique tissue regeneration system that has been used successfully in 33 clinical studies to grow bone tissue. The work has been licensed to a spin-off company, Orlumet LLC, in which Biris serves as Chief Technical Officer.The co-founder is Peder Jensen.

Biris is honorary president and co-founder of the Romanian Nanomedicine Institute in his native country. In addition to his groundbreaking research and work with graduate and undergraguate students, Biris works one-on-one with gifted middle- and high school students in Arkansas.

He said the key to the Nanotechnology Center at UALR is its aggressive outreach program to train and educate young people and other world-class scientists who will serve and attract business and industry to Arkansas from the region and the nation.

####

For more information, please click here

Contacts:
Joan I. Duffy
UALR Office of Communications
501.569.8600
@JIDuffy

Andrea Peel
UAMS Office of Communications
(501) 686-8996, (501) 351-7903 (cell)

Copyright © University of Arkansas at Little Rock

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Nanotubes/Buckyballs/Fullerenes

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nano-C Receives EPA Approvals for Single Walled Carbon Nanotubes July 21st, 2015

Nanomedicine

Stretching the limits on conducting wires July 25th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

Nanopaper as an optical sensing platform July 23rd, 2015

Albany College of Pharmacy and Health Sciences to Host One Week Symposium on Nanomedicine July 23rd, 2015

Discoveries

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Announcements

Detecting small metallic contaminants in food via magnetization: A practical metallic-contaminant detecting system using three high-Tc RF superconducting quantum interference devices (SQUIDs) July 29th, 2015

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

'Seeing' molecular interactions could give boost to organic electronics July 28th, 2015

Photonics/Optics/Lasers

Controlling phase changes in solids: Controlling phase changes in solids July 29th, 2015

Nanophase to present paper on slurry pH impact at Optics + Photonics conference July 28th, 2015

Perfect Optical Properties in Production of Aluminum Oxide Colloid Nanoparticles July 28th, 2015

Short wavelength plasmons observed in nanotubes: Berkeley Lab researchers create Ludinger liquid plasmons in metallic SWNTs July 28th, 2015

Alliances/Trade associations/Partnerships/Distributorships

Liquipel Debuts Eyesight-Saving ION-Glass Blue Light Protection for iPhones and Androids at RadioShack Stores Nationwide: Liquipel's Unique Protective Screen, Available at RadioShack, Cuts Harmful Blue Light Implicated in Macular Degeneration by 10x July 28th, 2015

Dais Analytic's Business Affiliate in China Announces Ten-Year Strategic Energy Efficiency Business Arrangement With COFCO: Dais Beijing to Perform Feasibility Study on Over 80 Buildings to Improve Efficiencies as Part of Overall Hotel Energy-Savings Project July 23rd, 2015

Leti and Diabeloop Project Aims at Developing Artificial Pancreas for Diabetes Treatment July 22nd, 2015

Imec and Panasonic Demonstrate Breakthrough RRAM Cell July 16th, 2015

Research partnerships

Spintronics: Molecules stabilizing magnetism: Organic molecules fixing the magnetic orientation of a cobalt surface/ building block for a compact and low-cost storage technology/ publication in Nature Materials July 25th, 2015

Stretching the limits on conducting wires July 25th, 2015

Ultra-thin hollow nanocages could reduce platinum use in fuel cell electrodes July 24th, 2015

UT Dallas nanotechnology research leads to super-elastic conducting fibers July 24th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project