- About Us
- Career Center
- Nano-Social Network
- Nano Consulting
- My Account
May 1st, 2009
US and UK scientists have discovered a safer contrast agent for magnetic resonance imaging (MRI). The agent is an alternative to commonly used, but potentially harmful, gadolinium-based agents.
MRI uses paramagnetic metals (contrast agents) to produce high resolution, non-invasive images of the body's internal structure. It is particularly useful in cardiovascular research for visualising blood clots in arteries, which can cause heart attacks and strokes. Although scientists normally use gadolinium as the contrast agent, its recent association with a serious tissue disorder in patients with kidney failure has prompted the development of new, safer imaging agents.
Dipanjan Pan, at Washington University School of Medicine, St Louis, US, and colleagues stirred manganese oxide nanoparticles in a vegetable oil and surfactant mixture to form manganese oxide nanocolloids with phospholipid shells. They showed that the nanocolloids are highly sensitive to fibrin, a major component of blood clots, and so are effective contrast agents.
The colloids can be easily metabolised and excreted by the human body, explains Pan, unlike other manganese-based contrast agents, which are difficult to eliminate and create a hazardous tissue residue. 'Bigger metal crystals are not metabolised and they are typically too large to be excreted through the kidney or bile, presenting an issue for long-term safety. We incorporate tiny manganese oxides or organically soluble chelated manganese into a stable nanoparticle, which is constrained within the vasculature [blood vessels]. This inherent difference over non-excretable nanocrystals should greatly improve the prospects of safety and clinical translation.'
|Related News Press|
News and information
Deep Space Industries and SFL selected to provide satellites for HawkEye 360ís Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016
Syracuse University chemists add color to chemical reactions: Chemists in the College of Arts and Sciences have come up with an innovative new way to visualize and monitor chemical reactions in real time May 19th, 2016
Nanoscale Trojan horses treat inflammation May 24th, 2016
Programmable materials find strength in molecular repetition May 23rd, 2016