Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > News > Nanocolloids identify blood clots

May 1st, 2009

Nanocolloids identify blood clots

Abstract:
US and UK scientists have discovered a safer contrast agent for magnetic resonance imaging (MRI). The agent is an alternative to commonly used, but potentially harmful, gadolinium-based agents.

MRI uses paramagnetic metals (contrast agents) to produce high resolution, non-invasive images of the body's internal structure. It is particularly useful in cardiovascular research for visualising blood clots in arteries, which can cause heart attacks and strokes. Although scientists normally use gadolinium as the contrast agent, its recent association with a serious tissue disorder in patients with kidney failure has prompted the development of new, safer imaging agents.

Dipanjan Pan, at Washington University School of Medicine, St Louis, US, and colleagues stirred manganese oxide nanoparticles in a vegetable oil and surfactant mixture to form manganese oxide nanocolloids with phospholipid shells. They showed that the nanocolloids are highly sensitive to fibrin, a major component of blood clots, and so are effective contrast agents.

The colloids can be easily metabolised and excreted by the human body, explains Pan, unlike other manganese-based contrast agents, which are difficult to eliminate and create a hazardous tissue residue. 'Bigger metal crystals are not metabolised and they are typically too large to be excreted through the kidney or bile, presenting an issue for long-term safety. We incorporate tiny manganese oxides or organically soluble chelated manganese into a stable nanoparticle, which is constrained within the vasculature [blood vessels]. This inherent difference over non-excretable nanocrystals should greatly improve the prospects of safety and clinical translation.'

Source:
rsc.org

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Chains of nanogold – forged with atomic precision September 23rd, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Nanotech Grants Options September 22nd, 2016

Coffee-infused foam removes lead from contaminated water September 21st, 2016

As You Sow’s Shareholder Inquiry on Nanomaterials Fought by Walgreens: Shareholder Proposal Addresses Recent Laboratory Tests Finding Harmful Nanomaterials in Walgreens’ Store Brand Infant Formula September 21st, 2016

Imaging

Oxford Instruments is ‘Bringing the Nanoworld Together’ in India once again - 22 - 23 November 2016 | IISc Bangalore September 21st, 2016

Bruker Introduces Complete Commercial AFM-Based SECM Solution: PeakForce SECM Mode Enables Previously Unobtainable Electrochemical Information September 20th, 2016

Nanomedicine

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

BBI Solutions launches innovative conjugate blocking technology that enhances signal intensity for lateral flow immunoassays September 20th, 2016

Iran to hold intl. school on application of nanomaterials in medicine September 20th, 2016

Graphene nanoribbons show promise for healing spinal injuries: Rice University scientists develop Texas-PEG to help knit severed, damaged spinal cords September 19th, 2016

Discoveries

Chains of nanogold – forged with atomic precision September 23rd, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Speedy bacteria detector could help prevent foodborne illnesses September 21st, 2016

Coffee-infused foam removes lead from contaminated water September 21st, 2016

Announcements

Chains of nanogold – forged with atomic precision September 23rd, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

Nanotech Grants Options September 22nd, 2016

Coffee-infused foam removes lead from contaminated water September 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic