- About Us
- Nano-Social Network
- Nano Consulting
- My Account
One of the challenges that cancer researchers face in designing new antitumor agents is that of predicting how drug molecules will behave in the complex microenvironment that surrounds a tumor. In particular, tumors create all sorts of chemical and physical barriers that limit how much drug is able to enter a tumor, let alone reach cells deep within a tumor. Now, Neil Forbes, Ph.D., and his colleagues at the University of Massachusetts have built a microfluidic device that can mimic these chemical and physical barriers, providing researchers with a new screening tool that may help with the design of more effective anticancer drugs.
Dr. Forbes and his colleagues, who reported their findings in the journal Lab on a Chip, designed this device to reproduce the three-dimensionality of a tumor, including areas of low pH and regions that contain cells resistant to therapy. To create this device, the investigators tested seven different cell growth chamber designs, using various imaging technologies to determine how closely cell masses growing in the device mimicked the behavior of a tumor. From these experiments, the investigators were able to select a growth chamber design that caused cells to grow into tumor masses that displayed heterogeneity closely resembling that of native tumors.
The investigators then used the device to study how doxorubicin, a widely used and widely studied anticancer drug, diffuses into and through a tumor. The device accurately modeled doxorubicin diffusion as seen in humans treated with this drug. The device also was able to recreate the accumulation patterns of anticancer bacteria that actively penetrate a tumor.
About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.
Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.
For more information, please click here
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
Copyright © National Cancer InstituteIf you have a comment, please Contact us.
Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.
|Related News Press|
News and information
Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017
Particle Works creates range of high performance quantum dots February 23rd, 2017
Zeroing in on the true nature of fluids within nanocapillaries: While exploring the behavior of fluids at the nanoscale, a group of researchers at the French National Center for Scientific Research discovered a peculiar state of fluid mixtures contained in microscopic channels January 11th, 2017