Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticles Detect Dying Cancer Cells

Abstract:
Two years ago, researchers at the University of South Australia discovered a new molecular marker specific for chemotherapy-induced cancer cell death. Now, those same investigators have used this marker to develop an imaging agent that can pinpoint tumor cell death using magnetic resonance imaging.

Nanoparticles Detect Dying Cancer Cells

Bethesda, MD | Posted on February 24th, 2009

Reporting its work in the journal Advanced Materials, a team of investigators led by Benjamin Thiery, Ph.D., first described a new synthetic method that produces monocrystalline iron oxide nanoparticles with a dense, uniform coating of the biocompatible polymer poly(ethylene glycol) (PEG). The resulting nanoparticle adsorbed much lower levels of blood proteins than do iron oxide nanoparticles coated using conventional methods, which had the effect of increasing the particles' half-life in blood.

Next, the investigators attached a specific monoclonal antibody to the PEG coating. This antibody binds to the La ribonucleoprotein, a molecule that is highly overexpressed by tumor cells. When tumor cells die by a process known as apoptosis, La ribonucleoprotein migrates to the cell membrane, where it is then accessible to the monoclonal antibody. Using multiple experimental models, the investigators showed that this antibody-nanoparticle construct bound with very high specificity to apoptotic cancer cells. The investigators are now conducting in vivo experiments to determine whether the nanoparticles can reveal the presence of apoptotic cancer cells in animals with human tumors.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

view journal citation - “Immunotargeting of functional nanoparticles for MRI detection of apoptotic tumor cells.”

Related News Press

News and information

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

RMIT researchers make leap in measuring quantum states July 21st, 2016

The future of perovskite solar cells has just got brighter -- come rain or shine: Korean researchers at POSTECH have succeeded in developing high-efficiency perovskite solar cells that retain excellent performance over two months in a very humid condition July 21st, 2016

Imaging

The birth of quantum holography: Making holograms of single light particles! July 21st, 2016

Graphene photodetectors: Thinking outside the 2-D box July 21st, 2016

A glimpse inside the atom: Using electron microscopes, it is possible to image individual atoms July 20th, 2016

Nanomedicine

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Research examines how to optimize nanoparticles for efficient drug delivery July 21st, 2016

Renishaw's inVia™ confocal Raman microscope is used to study blood stored in plastic blood bags July 19th, 2016

Keystone Nano selected as a top scoring company by NCI investor review panel July 19th, 2016

Discoveries

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

Research team led by NUS scientists develop plastic flexible magnetic memory device: Novel technique to implant high-performance magnetic memory chip on a flexible plastic surface without compromising performance July 21st, 2016

Announcements

Nanoparticle versus cancer: Scientists have created nanoparticles which cure cancer harmlessly July 22nd, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

New Yale-developed device lengthens the life of quantum information July 22nd, 2016

Graphene photodetectors: Thinking outside the 2-D box July 21st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic