Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > CELL PEN report considers health risks of nanomaterials in relation to cellular translocation

Abstract:
In a report published by DEFRA this week, the Institute of Occupational Medicine, Edinburgh, together with a team of multi-disciplinary experts presents an informed commentary and research agenda toward elucidating the importance of translocation in nanoparticle toxicology.

CELL PEN report considers health risks of nanomaterials in relation to cellular translocation

UK | Posted on January 22nd, 2009

One of the major concerns regarding the possible toxic effects of nanoparticles is the capacity of these materials to penetrate cells and potentially translocated to other cells, tissues and organs remote from the portal of entry to the body.

In a report published by DEFRA this week, the Institute of Occupational Medicine, Edinburgh, together with a team of multi-disciplinary experts presents an informed commentary and research agenda toward elucidating the importance of translocation in nanoparticle toxicology.

The project focussed on several key target sites of concern for particle translocation, namely; 1) pulmonary interstitium; 2) other lung cells; 3) blood; 4) blood vessel wall; 5) placenta/foetus; and 6) brain

Project outcomes highlight knowledge to date, research gaps, and outline a set of cross-cutting themes for future cell penetration studies, and a list of targeted recommendations for specific aspects of future translocation and penetration studies. Amongst these, are cross-cutting themes to be considered for future cell penetration/translocation studies, and targeted research priorities for both Mechanistic Toxicology Research (in vitro, in vivo & in silico); and Hazard Generation & Risk Assessment.

"Enhancing our knowledge of the physico-chemical properties which influence the efficacious, benign or toxic interaction between nanomaterials and cells will help inform our understanding of experimental observations and the design of engineered nanomaterials intended for particular applications" said Dr Steve Hankin, Senior Consultant at IOM & lead author of the report.

The consortium behind the report was formed from members of SnIRC (the Safety of Nanoparticles Interdisciplinary Research Centre) - including IOM, Edinburgh University, Napier University Edinburgh & Central Science Laboratories, York. In preparation of the report, opinion was also sought from a variety of leading experts across a range of stakeholder groups, from both within the UK and throughout Europe.

SM Hankin, CL Tran, B Ross, K Donaldson, V Stone, Q Chaudhry, 2008, ‘CELL PEN: A Study to identify the physico-chemical factors controlling the capacity of nanoparticles to penetrate cells; Report on DEFRA project CB0407 is free to download. To access it please click here: http://randd.defra.gov.uk/Document.aspx?Document=CB0407_7763_FRP.pdf (pdf, 514KB).


About the Institute of Occupational Medicine
The Institute of Occupational Medicine (www.iom-world.org) is a major independent centre of scientific excellence in the fields of occupational and environmental health, hygiene and safety. Our mission is to benefit those at work and in the community by providing quality research, consultancy and training in health, hygiene and safety and by maintaining our independent, impartial position as an international centre of excellence. The IOM has more than one hundred scientific, technical and support staff based in Edinburgh, Chesterfield, London and Stafford.

About SnIRC
SnIRC - The Safety of Nanomaterials Interdisciplinary Research Centre (www.snirc.org) aims to develop a conherent integrated program of work to increase awareness of the issues relating to nanoparticles, health and the environment, and to generate a comprehensive and coherent body of scientific evidence to aid development of UK nanotechnology whilst simultaneously safeguarding workplace, public and environmental health. SnIRC is based on existing collaborations between the Institute of Occupational Medicine in Edinburgh, Napier University, Aberdeen University, Edinburgh University and the US National Institute of Occupational Safety and Health (NIOSH).

####

For more information, please click here

Contacts:
Bryony Ross
Phone: +44 (0)131 449 8070


IOM:
Dr Steve Hankin
Senior Consultant
IOM

Copyright © SAFENANO

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Oxford Instruments’ Triton Cryofree dilution refrigerator selected by Oxford University for developing scalable quantum nanodevices September 2nd, 2015

JEOL Introduces New Best-in-Class Field Emission SEM September 2nd, 2015

TCL and QD Vision Demonstrate the Future of Wide Color Gamut Television at IFA: Color IQ Based Display is the First Commercially-Branded Television to Present Over 90% of ITU Rec. 2020 Color Gamut September 2nd, 2015

Atomic Force Microscopes from Asylum Research Guide the Development of Thin Film Deposition and Etch Processes September 2nd, 2015

Announcements

For 2-D boron, it's all about that base: Rice University theorists show flat boron form would depend on metal substrates September 2nd, 2015

Silk bio-ink could help advance tissue engineering with 3-D printers September 2nd, 2015

Phagraphene, a 'relative' of graphene, discovered September 2nd, 2015

A marine creature's magic trick explained: Crystal structures on the sea sapphire's back appear differently depending on the angle of reflection September 2nd, 2015

Safety-Nanoparticles/Risk management

Sustainable nanotechnology center September 1st, 2015

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Warning to DIY enthusiasts & construction workers as dangerous dust emissions August 19th, 2015

Bionic liver micro-organs explain off-target toxicity of acetaminophen (Tylenol): Israeli-German partnership aims to replace animal experiments with advanced liver-on-chip devices August 17th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic