Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Measuring Nanoparticle Behavior in the Body Using MRI

Abstract:
One of the key steps in the development of any drug or imaging agent intended for human use is measurement of the adsorption, metabolism, and excretion of the drug. Quantifying this collection of pharmacological properties, known as ADME, is a challenging and time-consuming process that is even more difficult when the drug or imaging agent includes a nanoparticle as one of its components. But by taking advantage of the magnetic properties of one kind of nanoparticle, a team of investigators at Washington University in St. Louis has demonstrated that they can measure ADME quickly using magnetic resonance imaging (MRI).

Measuring Nanoparticle Behavior in the Body Using MRI

Bethesda, MD | Posted on December 23rd, 2008

Reporting its work in the journal Magnetic Resonance in Medicine, a team of investigators led by Samuel Wickline, M.D., and Gregory Lanza, M.D., members of the Siteman Cancer Center for Nanotechnology Excellence, describe how it used MRI to measure the ADME properties in rabbits of a nanoparticle designed to bind to a molecule known as avb3, which is found on newly growing blood vessels such as those that surround most solid tumors and around atherosclerotic plaques. For comparison purposes, they also measured ADME for an untargeted but otherwise identical nanoparticle. In both cases, the nanoparticles were loaded with up to 90,000 gadolinium molecules, a number that is easily detected by MRI.

Prior to scanning, the animals had been fed a cholesterol-rich diet designed to spur atherosclerosis. After injecting the nanoparticles into the animals, the investigators scanned the animals using a research MRI instrument every 30 minutes for the next 2.5 hours and then at 8.5, 12.5, and 24 hours. These scans focused on the animals' aortas to determine ADME properties at the site that these nanoparticles were intended to target. The researchers also took blood samples at the time of imaging for calculating ADME using traditional methods.

Using standard modeling methods, the investigators were able to calculate multicompartmental pharmacokinetic parameters for the two different nanoparticles. Although the data showed that the overall blood levels of the two nanoparticles were nearly identical over the course of the experiment, the imaging results showed clearly that the amount of targeted nanoparticle at the aorta was double that of the untargeted nanoparticle, a result that is impossible to determine using standard ADME techniques. The researchers note that measuring local ADME characteristics with MRI, in addition to determining whole-body averaged results using blood samples, should become increasingly important as more targeted nanoparticles move toward human clinical trials.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging.”

Related News Press

News and information

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Imaging

Switching to spintronics: Berkeley Lab reports on electric field switching of ferromagnetism at room temp December 17th, 2014

ORNL microscopy pencils patterns in polymers at the nanoscale December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

DELMIC reports on applications of their SPARC technology at the Chalmers University of Technology in Gothenburg, Sweden December 16th, 2014

Nanomedicine

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Researchers Produce Electrical Pieces Usable in Human Body December 18th, 2014

Zenosense, Inc. - Hospital Collaboration - 400 Person Lung Cancer Detection Trial December 17th, 2014

Unraveling the light of fireflies December 17th, 2014

Discoveries

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Creation of 'Rocker' protein opens way for new smart molecules in medicine, other fields December 18th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

Announcements

Oregon researchers glimpse pathway of sunlight to electricity: Collaboration with Lund University uses modified UO spectroscopy equipment to study 'maze' of connections in photoactive quantum dots December 19th, 2014

Instant-start computers possible with new breakthrough December 19th, 2014

Aculon Hires New Business Development Director December 19th, 2014

Iranian Scientists Use Nanotechnology to Increase Power, Energy of Supercapacitors December 18th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE