Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Measuring Nanoparticle Behavior in the Body Using MRI

Abstract:
One of the key steps in the development of any drug or imaging agent intended for human use is measurement of the adsorption, metabolism, and excretion of the drug. Quantifying this collection of pharmacological properties, known as ADME, is a challenging and time-consuming process that is even more difficult when the drug or imaging agent includes a nanoparticle as one of its components. But by taking advantage of the magnetic properties of one kind of nanoparticle, a team of investigators at Washington University in St. Louis has demonstrated that they can measure ADME quickly using magnetic resonance imaging (MRI).

Measuring Nanoparticle Behavior in the Body Using MRI

Bethesda, MD | Posted on December 23rd, 2008

Reporting its work in the journal Magnetic Resonance in Medicine, a team of investigators led by Samuel Wickline, M.D., and Gregory Lanza, M.D., members of the Siteman Cancer Center for Nanotechnology Excellence, describe how it used MRI to measure the ADME properties in rabbits of a nanoparticle designed to bind to a molecule known as avb3, which is found on newly growing blood vessels such as those that surround most solid tumors and around atherosclerotic plaques. For comparison purposes, they also measured ADME for an untargeted but otherwise identical nanoparticle. In both cases, the nanoparticles were loaded with up to 90,000 gadolinium molecules, a number that is easily detected by MRI.

Prior to scanning, the animals had been fed a cholesterol-rich diet designed to spur atherosclerosis. After injecting the nanoparticles into the animals, the investigators scanned the animals using a research MRI instrument every 30 minutes for the next 2.5 hours and then at 8.5, 12.5, and 24 hours. These scans focused on the animals' aortas to determine ADME properties at the site that these nanoparticles were intended to target. The researchers also took blood samples at the time of imaging for calculating ADME using traditional methods.

Using standard modeling methods, the investigators were able to calculate multicompartmental pharmacokinetic parameters for the two different nanoparticles. Although the data showed that the overall blood levels of the two nanoparticles were nearly identical over the course of the experiment, the imaging results showed clearly that the amount of targeted nanoparticle at the aorta was double that of the untargeted nanoparticle, a result that is impossible to determine using standard ADME techniques. The researchers note that measuring local ADME characteristics with MRI, in addition to determining whole-body averaged results using blood samples, should become increasingly important as more targeted nanoparticles move toward human clinical trials.

####

About National Cancer Institute
The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Nanoparticle pharmacokinetic profiling in vivo using magnetic resonance imaging.”

Related News Press

Imaging

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

News and information

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanomedicine

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

Discoveries

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

PETA science group publishes a review on pulmonary effects of nanomaterials: Archives of Toxicology publishes a review of scientific studies on fibrotic potential of nanomaterials May 26th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Announcements

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic