Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > NanoVector to Commercialize First Biologic Nanoparticle Drug Delivery System

Abstract:
Plant Virus Nanoparticle is Nature's Perfect Vehicle for Targeted Intracellular Cancer Therapeutics

NanoVector to Commercialize First Biologic Nanoparticle Drug Delivery System

Raleigh, NC | Posted on December 3rd, 2008

NanoVector, Inc. announced today that it has licensed the plant virus nanoparticle drug delivery system developed by Professors' Stefan Franzen and Steven Lommel from North Carolina State University. "This is breakaway technology that will finally provide the highly sought after selective targeting of tumors and intracellular delivery of anti-cancer agents for improved efficacy and fewer unpleasant side effects," said Albert Bender, Ph.D., NanoVector CEO. "The plant virus nanoparticle has evolved over millions of years to have several inherent characteristics essential for a successful nanoparticle delivery system and superior to any chemistry based nanoparticle designed and engineered by humans." continued Dr. Bender.

The most important property of the virus is its built-in sensor-actuator system. When the virus carrying the therapeutic agent enters a cell, it senses a change in chemical environment and automatically unloads its cargo. Therefore the highly toxic therapeutic agent is released only in a cell, never in the blood stream as with manmade particles that depend upon capsule degradation or require an external trigger to open the particles for the release of their content. The benefit derived from this feature of the NanoVector nanoparticle is the minimization of the toxic side effects associated with free anti-cancer drugs in the blood stream that attack healthy cells.

A second feature of the plant virus is that its automatic release of cargo is not instantaneous once the virus enters a cell. This allows time for the licensed two-stage targeting in which nuclear importins attached to the nanoparticle guide it into the cell nucleus where it unloads its therapeutic agent, thereby maximizing efficacy and evading the cancer cell defenses. Delivery to the nucleus overcomes multi-drug resistance that occurs with current drug therapies.

Robustly protecting its cargo in very harsh environments is another property of the NanoVector plant virus nanoparticle. Unlike other viruses, the NanoVector plant virus is non-toxic to humans and, without specific cell targeting, will not accumulate in any body organs or otherwise healthy tissue. This makes it the perfect vehicle for targeted intracellular therapeutics.

####

About NanoVector, Inc.
NanoVector is an early stage biopharmaceutical company commercializing targeted intracellular therapeutics. The plant virus nanoparticle drug delivery platform will be used to develop a family of targeted delivery, encapsulated cytotoxic drugs that are currently non cell-selective for the $43B/yr worldwide cancer markets. NanoVector will also form strategic partnerships with pharmaceutical companies for joint development of targeted intracellular therapeutics for a wide range of indications.

NanoVector received a Small Business Research Loan from North Carolina Biotechnology Center and is in the process of raising a $1,000,000 seed round to fund taking the first drug through preclinical toxicity, safety, and stability studies required to submit an Investigational New Drug (IND) application to the FDA.

For more information, please click here

Contacts:
NanoVector, Inc.
Albert Bender, Ph.D.
CEO
919-878-8464

Copyright © Business Wire 2008

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Making graphene work for real-world devices: Fundamental research in phonon scattering helps researchers design graphene materials for applications April 24th, 2014

Return on investment for kit and promotion materials April 24th, 2014

Protecting olive oil from counterfeiters April 24th, 2014

NanoSafe, Inc. announces the addition of the Labconco Protector® Glove Box to its NanoSafe Tested™ registry April 23rd, 2014

Nanomedicine

Return on investment for kit and promotion materials April 24th, 2014

University of Tehran Researchers Invent Non-Enzyme Sensor to Detect Blood Sugar April 23rd, 2014

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell April 23rd, 2014

QuantuMDx announce prototype handheld lab for 15 minute malaria diagnosis and drug resistance testing April 23rd, 2014

Announcements

Making graphene work for real-world devices: Fundamental research in phonon scattering helps researchers design graphene materials for applications April 24th, 2014

Return on investment for kit and promotion materials April 24th, 2014

Protecting olive oil from counterfeiters April 24th, 2014

High-Performance, Low-Cost Ultracapacitors Built with Graphene and Carbon Nanotubes: Future devices based on technology could bridge gap between batteries and conventional capacitors in portable electronics and hybrid electric vehicles April 23rd, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE