Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Aphios Awarded SBIR Grant from National Institute on Drug Abuse (NIDA) for Nanotech Formulation of Δ9-THC for Marijuana Addiction and Other Unme

Abstract:
Aphios Corporation today announced receipt of a Phase I Small Business Innovative Research (SBIR) grant from the National Institute on Drug Abuse (NIDA) to develop an improved oral formulation of Δ9-THC for marijuana addiction and unmet medical needs.

Aphios Awarded SBIR Grant from National Institute on Drug Abuse (NIDA) for Nanotech Formulation of Δ9-THC for Marijuana Addiction and Other Unme

WOBURN, MA | Posted on October 28th, 2008

According to Dr. Trevor P. Castor, the grant's Principal Investigator, "In addition to helping marijuana addicts overcome their addiction, the nanotech formulation of Δ9-THC will have applicability in several other chronic diseases such as cancer pain, AIDS wasting, emesis, cachexia, obesity, smoking cessation, schizophrenia, multiple sclerosis and Parkinson's disease."

Innovative and novel dosage formulations are needed to improve the effectiveness and/or minimize the abuse potential of therapeutic agents for drug abuse/dependence. Examples of such agents are buprenorphine and delta-9-tetrahydrocannabinol (Δ9-THC). Buprenorphine has been approved for the treatment of opioid dependence. Sustained-release formulations that reduce the dosing frequency to once a week or once a month are expected to improve compliance thus effectiveness of treatment. Δ9-THC has been shown to alleviate marijuana withdrawal symptoms and has potential for treating marijuana dependence.

In the currently marketed formulation, synthetic Δ9-THC (Dronabinol®) is dissolved in sesame seed oil and is commercially available as an oral capsule (Marinol®). Oral administration causes slow, variable Δ9-THC uptake. In addition, it also requires drug administration several times a day. Δ9-THC is very hydrophobic and oxygen-sensitive, both factors that are challenges in making formulations that are orally bioavailable and stable. Formulations to improve bioavailability and reduce dosing frequency are expected to improve therapeutic effectiveness of Δ9-THC for marijuana addiction.

Aphios plans to utilize its patented SFS-CXP manufacturing technology platform to manufacture pharmaceutical grade Δ9-THC with a >99% purity following cGMP. Aphios will then utilize patented polymer nanospheres nanotechnology platform (SFS-PNS) to encapsulate Δ9-THC in biodegradable polymer nanospheres. Nanoencapsulation will protect Δ9-THC transport to the stomach and enhance its passage across the stomach lining of the gut. Nanoencapsulation will also slow the release of Δ9-THC, controlling the amount of drug in the bloodstream and reducing the frequency of drug administration during the day. Nanoencapsulation in biodegradable polymer nanospheres will thus improve Δ9-THC's stability, prolong circulation time and enhance bioavailability. Alternatively, the formulation will be utilized to deliver Δ9-THC from a subcutaneously implanted depot.

The project described herein was supported by Grant Number 1R43DA024552-01 from the National Institute on Drug Abuse. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Drug Abuse or the National Institutes of Health.

####

For more information, please click here

Contacts:
Aphios Corporation
Trevor P. Castor, Ph.D.
781-932-6933
CEO

Copyright © Business Wire 2008

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

A*STAR SIMTech wins international award for breaking new ground in actuators: SIMTech invention can be used in an array of industries, and is critical for next generation ultra-precision systems November 24th, 2014

Govt.-Legislation/Regulation/Funding/Policy

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Researchers engineer improvements of technology used in digital memory November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Nanomedicine

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research reveals how our bodies keep unwelcome visitors out of cell nuclei November 24th, 2014

ASU, IBM move ultrafast, low-cost DNA sequencing technology a step closer to reality November 24th, 2014

An Inside Job: UC-Designed Nanoparticles Infiltrate, Kill Cancer Cells From Within November 24th, 2014

Announcements

Vegetable oil ingredient key to destroying gastric disease bacteria: In mice, therapeutic nanoparticles dampen H. pylori bacteria and inflammation that lead to ulcers and gastric cancer November 25th, 2014

Research yields material made of single-atom layers that snap together like Legos November 25th, 2014

Blu-ray disc can be used to improve solar cell performance: Data storage pattern transferred to solar cell increases light absorption November 25th, 2014

Cooling with the coldest matter in the world November 24th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

A*STAR SIMTech wins international award for breaking new ground in actuators: SIMTech invention can be used in an array of industries, and is critical for next generation ultra-precision systems November 24th, 2014

SUNY Poly Student Awarded Fellowship with the U.S. Department of Energy's Postgraduate Research Program: Ph.D. Candidate Accepts Postmaster's Appointment To Conduct Research At Albany NanoTech Complex November 13th, 2014

MEMS Industry Group's 10th Annual Executive Conference Showcases Rapid Innovation in MEMS/Sensors: Emphasizes Spirit of Collaboration, Supporting First Open-Source Algorithm Community, New Standardization Efforts November 10th, 2014

Microrockets fueled by water neutralize chemical and biological warfare agents October 29th, 2014

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE