Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Northeastern’s Center for Pharmaceutical Biotechnology and Nanomedicine Receives $1.5M NIH Grant to Examine Drug Delivery

Abstract:
Vladimir Torchilin, Ph.D., professor and chair of the department of pharmaceutical sciences at Northeastern University's Bouvé College of Health Sciences, was recently awarded a 5-year, $1.54 million grant from the National Institutes of Health's (NIH) National Cancer Institute to investigate ways to increase the efficacy of nanocarrier-based pharmaceuticals for drug and gene therapy. Many pharmaceutical agents, such as drugs or DNA, need to enter the cell to carry out their therapeutic properties, and this study will address the challenges of getting these agents into the cell and reaching the target once inside.

Northeastern’s Center for Pharmaceutical Biotechnology and Nanomedicine Receives $1.5M NIH Grant to Examine Drug Delivery

Boston, MA | Posted on October 22nd, 2008

Torchilin, the study's principal investigator, is the director of the Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN). His research expertise is in the area of drug delivery systems using nanotechnology as a way to treat cancer and other diseases.

Nanomedicine, the medical application of nanotechnology, holds tremendous promise as a way to improve drug delivery systems. Pharmaceutical scientists are creating targeted drug delivery systems using nanoparticles that will allow the drugs or DNA to enter the cell and reach the intended target and exert their therapeutic function. The success of these agents once in the cell, however, is compromised because of cellular activities and functions, such as lysosomal degradation, which can alter the drug or the DNA and can make them ineffective.

The main objectives of this research project include developing the process of getting these pharmaceutical agents into the cell, identifying the target once inside the cell and protecting the integrity and activity of the drug or the DNA. Developing a platform for the creation of drug delivery systems capable of intracellular penetration, bypassing the cell wall and membrane, and targeting specific organelles, such as the mitochondria or lysosomes, will improve both the delivery of drugs and DNA and therapeutic outcomes for diseases such as cancer, lysosomal storage diseases, and diseases associated with genome dysfunctions.

"The ultimate goal of this research is to solve the extremely important and challenging problem of intracellular organelle-specific drug delivery, which will dramatically increase the efficacy of many therapies," said Torchilin.

Targeted drug delivery systems include gene therapy, inserting new genes into a cell to replace mutated genes, and antisense therapy, where a gene known to cause a disease is "turned off." For these systems, the genes are specifically targeted to carry out their therapeutic function in the nucleus, also located inside the cell. In addition, such delivery systems are suitable for anticancer pro-apoptotic drugs that target mitochondria, and lysosomal enzymes that need to reach the lysosomal compartment inside the cell.

The research team will prepare pharmaceutical nanocarriers, such as liposomes or micelles, that will envelope and protect the drug. They will also attach ligands to the outside of the nanocarrier that will assist in crossing the cell membrane and then binding to the target inside the cell. They will examine the interactions of these nanocarriers inside normal and cancer cells to see if they reach their target, such as nuclei or other intracellular organelles, and if they function correctly and improve the efficiency of the drug.

"We expect this research will lead to the development of a novel platform for targeted drug and gene delivery within cells and for provoking the effective apoptosis of cancer cells" added Torchilin. "Our hope is that this platform can be used to treat as many diseases as possible."

For more information about Professor Torchilin's research, please visit www.pharmsci.neu.edu/faculty/torchilin.html or contact Jenny Eriksen at (617) 373-2802 or via email at .

####

About Northeastern University
Founded in 1898, Northeastern University is a private research university located in the heart of Boston. Northeastern is a leader in interdisciplinary research, urban engagement, and the integration of classroom learning with real-world experience. The university's distinctive cooperative education program, where students alternate semesters of full-time study with semesters of paid work in fields relevant to their professional interests and major, is one of the largest and most innovative in the world. The University offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in six undergraduate colleges, eight graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Jenny Eriksen
(617) 373-2802

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Govt.-Legislation/Regulation/Funding/Policy

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

UT Dallas engineers twist nanofibers to create structures tougher than bulletproof vests March 27th, 2015

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Designer's toolkit for dynamic DNA nanomachines: Arm-waving nanorobot signals new flexibility in DNA origami March 27th, 2015

Nanomedicine

Novel nanoparticle therapy promotes wound healing March 27th, 2015

Graphene reduces wear of alumina ceramic March 26th, 2015

Application of Graphene Oxide in Body Implants in Iran March 26th, 2015

Nanorobotic agents open the blood-brain barrier, offering hope for new brain treatments March 25th, 2015

Announcements

Nanoscale worms provide new route to nano-necklace structures March 29th, 2015

Solving molybdenum disulfide's 'thin' problem: Research team increases material's light emission by twelve times March 29th, 2015

A first glimpse inside a macroscopic quantum state March 28th, 2015

DFG to Establish One Clinical Research Unit and Five Research Units: New Projects to Investigate Complications in Pregnancy, Particle Physics, Nanoparticles, Implants and Transport Planning / Approximately 13 Million Euros in Funding for an Initial Three-Year Period March 28th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

FEI Technology Award of the German Neuroscience Society Goes to Benjamin Judkewitz of the University of Berlin: Bi-annual award honors excellence in brain research during the German Neuroscience Society’s Annual Meeting, held 18-21 March 2015 March 26th, 2015

FEI Announces Image Contest Grand Prize Winner: Francisco Rangel of the National Institute of Technology, INT/MCTI, Brazil, wins the contest with his “Expanded Vermiculite” image March 23rd, 2015

Halas, Nordlander awarded Optical Society's R.W. Wood Prize: Rice University researchers recognized for pioneering nanophotonics March 21st, 2015

Hiden Instruments identified in London Stock Exchange’s ‘1000 Companies to Inspire Britain' March 21st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE