Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Northeastern’s Center for Pharmaceutical Biotechnology and Nanomedicine Receives $1.5M NIH Grant to Examine Drug Delivery

Abstract:
Vladimir Torchilin, Ph.D., professor and chair of the department of pharmaceutical sciences at Northeastern University's Bouvé College of Health Sciences, was recently awarded a 5-year, $1.54 million grant from the National Institutes of Health's (NIH) National Cancer Institute to investigate ways to increase the efficacy of nanocarrier-based pharmaceuticals for drug and gene therapy. Many pharmaceutical agents, such as drugs or DNA, need to enter the cell to carry out their therapeutic properties, and this study will address the challenges of getting these agents into the cell and reaching the target once inside.

Northeastern’s Center for Pharmaceutical Biotechnology and Nanomedicine Receives $1.5M NIH Grant to Examine Drug Delivery

Boston, MA | Posted on October 22nd, 2008

Torchilin, the study's principal investigator, is the director of the Center for Pharmaceutical Biotechnology and Nanomedicine (CPBN). His research expertise is in the area of drug delivery systems using nanotechnology as a way to treat cancer and other diseases.

Nanomedicine, the medical application of nanotechnology, holds tremendous promise as a way to improve drug delivery systems. Pharmaceutical scientists are creating targeted drug delivery systems using nanoparticles that will allow the drugs or DNA to enter the cell and reach the intended target and exert their therapeutic function. The success of these agents once in the cell, however, is compromised because of cellular activities and functions, such as lysosomal degradation, which can alter the drug or the DNA and can make them ineffective.

The main objectives of this research project include developing the process of getting these pharmaceutical agents into the cell, identifying the target once inside the cell and protecting the integrity and activity of the drug or the DNA. Developing a platform for the creation of drug delivery systems capable of intracellular penetration, bypassing the cell wall and membrane, and targeting specific organelles, such as the mitochondria or lysosomes, will improve both the delivery of drugs and DNA and therapeutic outcomes for diseases such as cancer, lysosomal storage diseases, and diseases associated with genome dysfunctions.

"The ultimate goal of this research is to solve the extremely important and challenging problem of intracellular organelle-specific drug delivery, which will dramatically increase the efficacy of many therapies," said Torchilin.

Targeted drug delivery systems include gene therapy, inserting new genes into a cell to replace mutated genes, and antisense therapy, where a gene known to cause a disease is "turned off." For these systems, the genes are specifically targeted to carry out their therapeutic function in the nucleus, also located inside the cell. In addition, such delivery systems are suitable for anticancer pro-apoptotic drugs that target mitochondria, and lysosomal enzymes that need to reach the lysosomal compartment inside the cell.

The research team will prepare pharmaceutical nanocarriers, such as liposomes or micelles, that will envelope and protect the drug. They will also attach ligands to the outside of the nanocarrier that will assist in crossing the cell membrane and then binding to the target inside the cell. They will examine the interactions of these nanocarriers inside normal and cancer cells to see if they reach their target, such as nuclei or other intracellular organelles, and if they function correctly and improve the efficiency of the drug.

"We expect this research will lead to the development of a novel platform for targeted drug and gene delivery within cells and for provoking the effective apoptosis of cancer cells" added Torchilin. "Our hope is that this platform can be used to treat as many diseases as possible."

For more information about Professor Torchilin's research, please visit www.pharmsci.neu.edu/faculty/torchilin.html or contact Jenny Eriksen at (617) 373-2802 or via email at .

####

About Northeastern University
Founded in 1898, Northeastern University is a private research university located in the heart of Boston. Northeastern is a leader in interdisciplinary research, urban engagement, and the integration of classroom learning with real-world experience. The university's distinctive cooperative education program, where students alternate semesters of full-time study with semesters of paid work in fields relevant to their professional interests and major, is one of the largest and most innovative in the world. The University offers a comprehensive range of undergraduate and graduate programs leading to degrees through the doctorate in six undergraduate colleges, eight graduate schools, and two part-time divisions.

For more information, please click here

Contacts:
Jenny Eriksen
(617) 373-2802

Copyright © Northeastern University

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Organometallics welcomes new editor-in-chief: Paul Chirik, Ph.D. July 22nd, 2014

The Hiden EQP Plasma Diagnostic with on-board MCA July 22nd, 2014

Iran to Hold 3rd Int'l Forum on Nanotechnology Economy July 22nd, 2014

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Govt.-Legislation/Regulation/Funding/Policy

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

Oregon chemists eye improved thin films with metal substitution: Solution-based inorganic process could drive more efficient electronics and solar devices July 21st, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Nanomedicine

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

SentiMag® Now Available in Australia and New Zealand July 21st, 2014

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs July 21st, 2014

Announcements

Nanometrics Announces Upcoming Investor Events July 22nd, 2014

Bruker Awarded Fourth PeakForce Tapping Patent: AFM Mode Uniquely Combines Highest Resolution Imaging and Material Property Mapping July 22nd, 2014

NIST shows ultrasonically propelled nanorods spin dizzyingly fast July 22nd, 2014

Penn Study: Understanding Graphene’s Electrical Properties on an Atomic Level July 22nd, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Researchers create vaccine for dust-mite allergies Main Page Content: Vaccine reduced lung inflammation to allergens in lab and animal tests July 22nd, 2014

EPFL Research on the use of AFM based nanoscale IR spectroscopy for the study of single amyloid molecules wins poster competition at Swiss Physics Society meeting July 22nd, 2014

Carbyne morphs when stretched: Rice University calculations show carbon-atom chain would go metal to semiconductor July 21st, 2014

Albany NanoCollege Faculty Member Selected as Editor-in-Chief of the Prestigious Journal of Electronic Materials July 1st, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE