Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Multifunctional Polymer Nanoparticles Pass Critical In Vivo Test

Abstract:
In an effort to overcome the drug resistance that often occurs in cancer, a team of investigators has developed a nanoparticle made of a blend of polymers that first releases a powerful anticancer drug and then delivers an agent that tricks a drug-resistant cell into committing suicide. Now, tests in mice with human breast cancer have shown that these blended nanoparticles are effective in maintaining high levels of both drugs in the vicinity of tumors.

Multifunctional Polymer Nanoparticles Pass Critical In Vivo Test

Bethesda, MD | Posted on September 27th, 2008

Mansoor Amiji, Ph.D., Principal Investigator, Nanotherapeutic Strategy for Multidrug-Resistant Tumors Platform Partnership at Northeastern University, led the research team that reported on this study in the journal Molecular Pharmaceutics. This platform partnership is part of the NCI Alliance for Nanotechnology in Cancer, a comprehensive initiative designed to accelerate the application of nanotechnology to the prevention, diagnosis, and treatment of cancer.

In a previous study, Dr. Amiji and his collaborators showed that the combination of the anticancer drug paclitaxel and a molecule known as ceramide was able to kill drug-resistant breast cancer cells growing in culture. Ceramide is a naturally occurring compound that cells produce to trigger apoptosis (programmed cell death) when the cells suffer irreversible damage, such as when they are exposed to an anticancer drug. Tumor cells that have developed drug resistance are able to destroy ceramide before it triggers the apoptosis pathway.

In the current study, these two drugs were encapsulated in a single nanoparticle made of two polymers. One polymer, known as poly(beta-amino ester) (PbAE), dissolves rapidly in the acidic environment inside tumor cells, and the researchers used that polymer to encapsulate paclitaxel. The second polymer, poly(d,l-lactide-co­-glycolide) (PLGA), dissolves far more slowly under the same conditions, affording a means of encapsulating ceramide for release after a time delay, when a drug-resistant cell will be trying to avoid apoptosis.

The researchers injected these nanoparticles into mice with human breast tumors. They then measured drug concentrations both in blood and in the vicinity of the tumors. The results showed that this blended nanoparticle was able to sustain high levels of the drugs in the mice and that, as a result, the drugs accumulated in the tumors. This study was not intended to determine whether the drugs had the desired therapeutic effect; those data will come from studies that are now under way.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Biodistribution and Pharmacokinetic Analysis of Paclitaxel and Ceramide Administered in Multifunctional Polymer-Blend Nanoparticles in Drug Resistant Breast Cancer Model.”

Related News Press

News and information

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

Nanomedicine

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Harris & Harris Group Continues Its Blog Series to Highlight Most Impactful Portfolio Companies With Champions Oncology, Inc. April 17th, 2014

UT Arlington physicist creates new nanoparticle for cancer therapy April 16th, 2014

Discoveries

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Scientists Capture Ultrafast Snapshots of Light-Driven Superconductivity: X-rays reveal how rapidly vanishing 'charge stripes' may be behind laser-induced high-temperature superconductivity April 16th, 2014

Scientists observe quantum superconductor-metal transition and superconducting glass: A team including MIPT physicist observed quantum superconductor-metal transition and superconducting glass April 16th, 2014

Announcements

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE