Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Targeted Nanoparticles Map Tumor Blood Supply in 3-D, Assess Therapy

Abstract:
One of the defining characteristics of solid tumors is the development of a network of new blood vessels to nourish the rapidly reproducing malignant cells. Now, using a nanoparticle targeted to those new blood vessels, a joint academic-industrial research team, led by investigators from the Siteman Center of Cancer Nanotechnology Excellence, has developed a way to construct a three-dimensional (3-D) map of tumor-induced angiogenesis and monitor the effects of drug therapies on those new blood vessels.

Targeted Nanoparticles Map Tumor Blood Supply in 3-D, Assess Therapy

Bethesda , MD | Posted on September 27th, 2008

Reporting its work in the FASEB Journal, a research team headed by Washington University in St. Louis colleagues Gregory Lanza, M.D., and Samuel Wickline, M.D., described its development of a perfluorinated nanoparticle loaded with gadolinium ions, which boost magnetic resonance imaging (MRI) signals, and then coating this nanoparticle with a peptide that targets new blood vessels. This particular peptide binds strongly to a cell-surface protein known as a5b1 integrin. For the sake of comparison, the investigators also prepared an identical nanoparticle but coated it with a related peptide that does not bind to a5b1 integrin. They also prepared a third nanoparticle coated with a small organic molecule that binds to both a5b1 integrin and avb3 integrin.

When the investigators injected the nanoparticle targeted to a5b1 integrin into tumor-bearing mice, they were able to use MRI to produce a 3-D map of tumor-associated blood vessels. From this map, the researchers were able to show that nearly all of the new blood vessels were on the rim of the tumor. The investigators confirmed these findings through microscopic examination of the tumors after they had been removed surgically from the mice.

Next, the investigators injected the mice with nanoparticles loaded with a drug known as fumigillin, which stops new blood vessel growth. Some of these nanoparticles were coated with the a5b1 integrin targeting peptide, whereas others were coated with the small organic molecule that binds to both a5b1 integrin and avb3 integrin. They then used the MRI-enhancing nanoparticle that targeted a5b1 integrin and avb3 integrin to assess any therapeutic changes produced by the fumagillin-loaded nanoparticles. The resulting 3-D images showed that the dual-targeted, drug-loaded nanoparticle decreased tumor-associated angiogenesis to near neglible levels. The singly targeted nanoparticles were less effective, and the untargeted nanoparticle was ineffective at reducing angiogenesis.

Somewhat surprisingly, the reduction in angiogenesis did not have an effect on tumor size. The researchers attributed this observation to the fact that the tumor model they used does not produce as much angiogenesis as do other more common models of human cancer. The researchers chose this model because they wanted to determine whether their nanoparticles could image relatively sparse angiogenesis, a normally difficult proposition.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View Abstract - “In Vivo Tumor Cell Targeting With ‘Click’ Nanoparticles.”

Related News Press

News and information

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Nanotech could rid cattle of ticks, with less collateral damage September 1st, 2015

Imaging

Nanolab Technologies LEAPS Forward with High-Performance Analysis Services to the World: Nanolab Orders Advanced Local Electrode Atom Probe (LEAP®) Microscope from CAMECA Unit of AMETEK Materials Analysis Division August 27th, 2015

50 Years of Scanning Electron Microscopy from ZEISS: ZEISS celebrates the birth of the first commercial scanning electron microscope in 1965 August 26th, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Kwansei Gakuin University in Hyogo, Japan, uses Raman microscopy to study crystallographic defects in silicon carbide wafers August 25th, 2015

Nanomedicine

Using DNA origami to build nanodevices of the future September 1st, 2015

Efficiency of Nanodrug Containing Antibiotics in Treatment of Infectious Diseases Evaluated August 31st, 2015

Researchers use DNA 'clews' to shuttle CRISPR-Cas9 gene-editing tool into cells August 30th, 2015

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Discoveries

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Scientists 'squeeze' light one particle at a time: A team of scientists have measured a bizarre effect in quantum physics, in which individual particles of light are said to have been 'squeezed' -- an achievement which at least one textbook had written off as hopeless September 1st, 2015

Using ultrathin sheets to discover new class of wrapped shapes: UMass Amherst materials researchers describe a new regime of wrapped shapes August 31st, 2015

Announcements

$200K Awarded to Develop In Vitro Lung Test for Toxicity of Inhaled Nanomaterials: In Vitro Lung Test Designed to Protect Human Health and Replace Animal Testing September 1st, 2015

Hot electrons point the way to perfect light absorption: Physicists study how to achieve perfect absorption of light with the help of rough ultrathin films September 1st, 2015

Using DNA origami to build nanodevices of the future September 1st, 2015

Nanotech could rid cattle of ticks, with less collateral damage September 1st, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic