Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Switchable bio-adhesion

Abstract:
Researchers have developed a new type of property-changing polymer: It is water-repellent at 37░C, which makes it an ideal culture substrate for biological cells. At room temperature it attracts water, allowing the cells to be detached easily from the substrate.

Switchable bio-adhesion

Germany | Posted on September 1st, 2008



What effects do new drugs have on the human body - particularly at cellular level? Can doctors administer them without risk, or do they have toxic side effects? Pharmaceutical companies carry out a variety of toxicity tests on new drugs in order to answer such questions. Cell cultures form the basis for these tests: The researchers place isolated cells in small plastic dishes, add a nutrient solution and place the dishes in an incubator heated to 37 degrees Celsius. To provide an ideal breeding ground for the cells, the dishes are made of insulating polystyrene. Once the cells have multiplied to the required number, the drug is added. However, to examine the cells' reaction to the drug, the researchers then have to remove the cultured cells from the dish. The problem is that the cells often adhere so firmly to the surface of the dish that an enzyme has to be introduced to detach them. "The cells employed in toxicity tests are particularly sensitive, and can be damaged by the added enzyme. This makes it difficult to interpret the test results. It cannot be established without doubt whether the cells' reaction to the drug has been influenced by damage caused by the method used to extract them from the dish" says Dr. Claus Duschl, department head at the Fraunhofer Institute for Biomedical Engineering IBMT in Potsdam-Golm.

A possible solution is the stimuli-responsive polymer developed by a team led by Dr. Jean-Franšois Lutz of the Fraunhofer Institute for Applied Polymer Research IAP, assisted by colleagues at the IBMT and the Max Planck Institute of Colloids and Interfaces. "At 37 degrees Celsius, the usual incubation temperature for cell cultures, this material is water-repellent (hydrophobic) - the cells feel at ease in this environment and respond by multiplying rapidly. If the substrate is cooled to 25 degrees, equivalent to room temperature, the material becomes hydrophilic (attracts water): The cells try to avoid contact with the substrate by reducing their surface area, curling up into almost spherical shapes. This enables them to be rinsed off easily, so there is no longer any need to add an enzyme," explains Lutz.

This is not the first thermoresponsive polymer. The big difference is that it is based on polyethylene glycol (PEG), which unlike other materials of this type is biocompatible. It is thus an ideal substrate for cell cultures. The new material has the added advantage of being water-soluble and non-toxic. Lutz estimates that it will be possible to mass-produce Petri dishes coated with the new property-changing polymer in about two or three years' time.

####

About Fraunhofer-Gesellschaft
The Fraunhofer-Gesellschaft undertakes applied research of direct utility to private and public enterprise and of wide benefit to society.

For more information, please click here

Contacts:
Dr. Jean-Francois Lutz
Phone: +49 331 568-1127
Send an e-mail
Fraunhofer Institute for Applied Polymer Research
IAP
Geiselbergstra▀e 69
14476 Potsdam-Golm

Copyright © Fraunhofer-Gesellschaft

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Maximum Precision in 3D Printing: New complete solution makes additive manufacturing standard for microfabrication February 26th, 2015

Nanomedicine

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Cutting-edge technology optimizes cancer therapy with nanomedicine drug combinations: UCLA bioengineers develop platform that offers personalized approach to treatment February 24th, 2015

Optical nanoantennas set the stage for a NEMS lab-on-a-chip revolution February 24th, 2015

Discoveries

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Materials/Metamaterials

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

In quest for better lithium-air batteries, chemists boost carbon's stability: Nanoparticle coatings improve stability, cyclability of '3DOm' carbon February 25th, 2015

Learning by eye: Silicon micro-funnels increase the efficiency of solar cells February 25th, 2015

Announcements

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE