Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing

Abstract:
Scientists at the California Institute of Technology (Caltech) have developed a simple process for mass producing molecular tubes of identical--and precisely programmable--circumferences. The technological feat may allow the use of the molecular tubes in a number of nanotechnology applications.

Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing

PASADENA, CA | Posted on August 29th, 2008

The molecular tubes are composed of wound-up strands of DNA. DNA has been considered an ideal construction material for self-assembling molecular structures and devices because two complementary DNA strands can automatically recognize and bind with each other. DNA has been used to form rigid building blocks, known as tiles, and these tiles can further assemble into extended lattice structures, including tubes. However, it has been difficult to control the diameters of such tubes.

Peng Yin, a senior postdoctoral scholar in bioengineering and computer science at Caltech's Center for Biological Circuit Design, along with his colleagues has designed a series of flexible, single-stranded DNA molecules, called single-stranded DNA tiles. Each single-stranded tile is exactly 42 bases long and contains four modular binding sites. By pairing up the complementary binding sites, these single-stranded tiles bind with each other in a particular orientation like Lego pieces snapped together, forming a tube composed of parallel DNA helices.

The circumference of the resulting tube is determined by the number of different 42-base pieces used in its construction. For example, four pieces create a tube with a circumference of 12 billionths of a meter (or 12 nanometers); five pieces, a 15-nanometer-circumference tube; and six pieces, an 18-nanometer tube.

"We are not the first to make DNA tubes with controlled circumferences. However, compared with previous approaches, our method is distinctively simple and modular," says Yin. The simplicity and modularity of their approach permits the description of the tube design using a simple graphical abstraction system developed earlier this year in the laboratory of Niles Pierce, associate professor_of applied and computational mathematics and bioengineering at Caltech.

Just as a variety of wood sizes are used in construction projects--two by four inches for framing walls, two by eight inches for roof rafters, or four by four inches for fence posts--having nanotubes of various, precisely controlled sizes provides their user with more options. In addition, nanotubes of different sizes have varying mechanical properties; for example, tubes with a smaller diameter are more flexible and tubes with a larger diameter are more rigid. The nanotubes might eventually serve as templates for manufacturing nanowires with controlled diameters; the diameters of electron-conducting nanowires would help determine the electronic properties of the devices they are used to construct.

"The simplicity of the single-stranded tile approach promises to enable us to design ever more complex self-assembling molecular systems. The work is simultaneously elegant and useful," says Erik Winfree, associate professor of computer science, computation and neural systems, and bioengineering at Caltech. Winfree's laboratory was the primary host of Yin's research at Caltech.

The paper, "Programming DNA Tube Circumferences," was published August 8 in the journal Science. Yin's coauthors are applied physics graduate student Rizal Hariadi and computer science postdoctoral scholar Sung Ha Park from Erik Winfree's group; bioengineering graduate student Harry Choi from Niles Pierce's group; and computer science graduate student Sudheer Sahu at Duke University; Thomas LaBean, associate research professor of computer science and chemistry at Duke University; and John Reif, professor of computer science at Duke University.

The work was funded by the Center for Biological Circuit Design at Caltech and the National Science Foundation.

Visit the Caltech Media Relations website at pr.caltech.edu/media.

####

For more information, please click here

Contacts:
Kathy Svitil

626-395-8022

Copyright © California Institute of Technology

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Molecular Machines

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Breakthrough laser experiment reveals liquid-like motion of atoms in an ultra-cold cluster: University of Leicester research team unlocks insights into creation of new nano-materials July 25th, 2014

Molecular Nanotechnology

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Crystallizing the DNA nanotechnology dream: Scientists have designed the first large DNA crystals with precisely prescribed depths and complex 3D features, which could create revolutionary nanodevices October 20th, 2014

Fast, cheap nanomanufacturing: Arrays of tiny conical tips that eject ionized materials could fabricate nanoscale devices cheaply October 4th, 2014

Nano-bearings on the test bench: Fullerene spheres can be used to slide in the nanoworld October 3rd, 2014

Discoveries

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

Announcements

Nano Ruffles in Brain Matter: Freiburg researchers decipher the role of nanostructures around brain cells in central nervous system function October 31st, 2014

Gold nanoparticle chains confine light to the nanoscale October 31st, 2014

'Nanomotor lithography' answers call for affordable, simpler device manufacturing October 31st, 2014

Device invented at Johns Hopkins provides up-close look at cancer on the move: Microscopic view of metastasis could give insight about how to keep cancer in check October 31st, 2014

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE