Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Harvard University and Oxford Nanopore Technologies Announce Licence Agreement to Advance Nanopore DNA Sequencing and other Applications

Abstract:
Harvard University's Office of Technology Development ("Harvard") and Oxford Nanopore Technologies Ltd ("Oxford Nanopore") today announced an agreement to progress nanopore science by integrating Harvard discoveries with technology in development at Oxford Nanopore.

Harvard University and Oxford Nanopore Technologies Announce Licence Agreement to Advance Nanopore DNA Sequencing and other Applications

Cambridge, MA | Posted on August 5th, 2008

Under the terms of this agreement with Harvard, Oxford Nanopore has exclusive rights to develop and commercialize a number of nanopore technological breakthroughs developed in the laboratories of three investigators at Harvard and their collaborators at the University of California Santa Cruz (UCSC) and the National Institute of Standards and Technology (NIST), an agency of the US Department of Commerce. The investigators include: Professors Daniel Branton, George Church and Jene Golovchenko at Harvard; David Deamer and Mark Akeson at UCSC and John Kasianowicz at NIST.

These academics have pioneered the research of DNA translocation through nanopores and the potential for DNA sequencing using this method. This is complementary to the work of Professor Hagan Bayley, the founder of Oxford Nanopore Technologies. Professor Bayley pioneered the field of nanopores as sensors of single molecules, with a specific focus on the identification of DNA bases.

Oxford Nanopore will also support fundamental nanopore research at Harvard, facilitating further advancement of the field and generating opportunities for further evolutions of nanopore sequencing technology.

"The inventions licensed to Oxford Nanopore resulted from strong collaboration across multiple disciplines at Harvard, and also with academic colleagues from outside of the University," said Isaac T. Kohlberg, Senior Associate Provost and Chief Technology Development Officer at Harvard University. "This work and the agreement announced today are further validation of Harvard's strong commitment to collaboration and innovation, and to ensuring that the work of our scientists is extended to benefit society more broadly."

Dr Gordon Sanghera, CEO of Oxford Nanopore Technologies, added: "We are proud to collaborate with this world-class research team. Harvard's long record of excellence in nanopore research means that this agreement encompasses many aspects of nanopore technology. Through this partnership and agreements with other prestigious institutions, Oxford Nanopore takes the leading position in transforming nanopores from science into technologies that will benefit researchers and people everywhere."

Oxford Nanopore is developing nanopores for use in DNA sequencing and the analysis of other molecules. A nanopore is a small hole; this inner diameter is small enough to be used in the direct identification of many single molecules, without using chemical labels. This technology has the potential to deliver a dramatic reduction in the cost and speed of DNA sequencing, benefiting basic medical research and further the field of personalized medicine.

A dramatic improvement in sequencing technology would have a profound effect on life science and medical research, furthering genome research and the development of new medical diagnostics, treatments and strategies. There are many additional applications of sequencing, within the fields of defense, energy and agriculture.

The single molecule analysis platform being developed at Oxford Nanopore is label-free, and is therefore positioned to deliver a step-change in the power and cost of DNA sequencing. While current technologies rely on expensive fluorescent labels, optical equipment for signal detection and informatics to translate image data into sequence data, nanopores bypass the optical detection by providing a direct electrical recording of DNA base identification. The method is highly scalable through silicon chip arrays.

Financial terms of the agreement were not disclosed.

####

About Harvard University’s Office of Technology Development
The Harvard Office of Technology Development (OTD) is responsible for all activities pertaining to the evaluation, patenting and licensing of new inventions and discoveries made at Harvard University and Harvard Medical School. OTD also serves to further the development of Harvard technologies through the establishment of sponsored research collaborations with industry. OTD’s mission is to promote the public good by fostering innovation and translating new inventions made at Harvard into useful products available and beneficial to society.

The Harvard Nanopore Group

The Harvard Nanopore Group is led by Professor Daniel Branton and Professor Jene Golovchenko. The group has been investigating electronic methods of very rapidly detecting, characterizing and sequencing single molecules of DNA. A detector consisting of a single nanopore in a thin, insulating, solid-state membrane could mimic the function of a-hemolysin pores in lipid bilayers, while serving as a platform for integrated electronic detection devices. The group’s research has lead to the development of a new ion beam based method for creating nanoscale structures in semiconductors called "ion beam sculpting".

The Group is also developing other applications that may utilize the sensitivity and speed of nanopore probing, and is investigating the physics of DNA polymer movement through the confined space of a nanopore, coordinating the application of material science tools to fabricate solid-state nanopores, and developing the associated biochemistry, molecular biology, electronics, and signal processing to effect molecular recognition. www.mcb.harvard.edu/branton/

Professor Daniel Branton, Higgins Professor of Biology Emeritus, Harvard University

Professor Branton’s research areas include Nanopore technology and single molecule probing, molecular organization of cell membranes and cell biology. He has held positions at Harvard University in Cambridge, MA and the University of California, Berkeley. www.mcb.harvard.edu/Faculty/Branton.html

Professor Jene Golovchenko Rumsford Professor of Physics and Gordon McKay Professor of Applied Physics – Harvard University.

Professor Jene Golovchenko has had a broad research career, encompassing research posts at Harvard University, Aarhus University in Denmark, in industry, at Bell Labs, in national laboratories at Brookhaven and Livermore and at CERN in Geneva, Switzerland. He is also a member of the Rowland Institute for Science, an interdisciplinary non-profit basic research institute in Cambridge.

Professor Golovchenko specializes in studying the fundamental interactions of radiation and matter and the application of this knowledge to revealing and controlling the properties of materials.

Oxford Nanopore Technologies Ltd.

Oxford Nanopore is developing nanopore technology, a revolutionary method of molecular detection and analysis with potential for DNA sequencing, diagnostics, drug development and defence applications. The company was founded on the science of Professor Hagan Bayley of the University of Oxford, who pioneered the stochastic sensing of single molecules using engineered protein nanopores, and has published a method to differentiate between DNA bases using a nanopore.

The Company’s BASE™ technology is a system for DNA sequencing that employs nanopores to process, identify and record DNA bases in sequence. In contrast to current sequencing technologies, nanopores offer a potential method of directly sequencing DNA at single molecule resolution. This removes the need for amplification or labelling, and allows detection from an electrical signal rather than by fluorescence-based CCD imaging. In order to make a breakthrough in speed and cost, other competing technologies require step changes in optics, computation and CCD camera technologies. Nanopores provide an alternative path to a step-change in the power and cost of DNA sequencing.

Recent interest in the “race for the $1000 genome" illustrates the needs for a sequencing technology that is affordable and powerful enough to provide more researchers with affordable sequencing power. This is expected to enable an exponential increase in research and understanding of the genome, and accelerate new developments in medicine, agriculture, energy, biodiversity, evolutionary biology, genealogy and many other fields.

The nanopore molecular detection system is powerful and versatile beyond its DNA sequencing potential. It can be adapted to detect a wide range of molecules, including other nucleic acids, proteins, small organic molecules and ionic species.

Oxford Nanopore Technologies holds license agreements for the development and commercialization of nanopore technology with the foremost institutions in nanopore science. These include the University of Oxford, Harvard University, the University of California, Santa Cruz, Texas A&M, the University of Massachusetts Medical School and the National Institute of Standards and Technology (NIST). This places the Company in a unique and leading position for bringing first and future generations of nanopore technology to the market.

www.nanoporetech.com

For more information, please click here

Contacts:
Harvard University
Larry Schlossman
Office of Technology Development

or
Oxford Nanopore Technologies
Dr Gordon Sanghera, CEO
Zoe McDougall, Communications
+44 (0) 870 486 1966
or
Feinstein Kean Healthcare
Krystle Ficco
+1-617-761-6702

Copyright © Business Wire 2008

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Shaping the Future of Nanocrystals: Berkeley Lab Researchers Obtain First Direct Observation of Facet Formation in Nanocubes August 21st, 2014

Hiden Release New Gas Analysis Catalogue August 21st, 2014

Wyatt Technology’s 24th International Light Scattering Colloquium to Highlight Developments in Applications and Characterization of Nanoparticles August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Nanomedicine

Ultra-short pulse lasers & Positioning August 21st, 2014

Nanotechnology Helps Production of Super Adsorbent Polymers August 21st, 2014

Newly-Developed Nanobiosensor Quickly Diagnoses Cancer August 20th, 2014

Graphene rubber bands could stretch limits of current healthcare, new research finds August 19th, 2014

Announcements

Wyatt Technology’s 24th International Light Scattering Colloquium to Highlight Developments in Applications and Characterization of Nanoparticles August 21st, 2014

Ultra-short pulse lasers & Positioning August 21st, 2014

Malvern’s Dr Alan Rawle talks TLAs in plenary lecture at Particulate Systems Analysis conference August 21st, 2014

Water window imaging opportunity: A new theoretical study elucidates mechanisms that could help in producing coherent radiations, ultimately promoting high-contrast imaging of biological samples August 21st, 2014

Patents/IP/Tech Transfer/Licensing

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Blacktrace Holdings Ltd. to in-license PerkinElmer Technology August 8th, 2014

Silicene Labs Announces the Launch of Patent-Pending, 2D Materials Composite Index™ : The Initial 2D Materials Composite Index™ for Q2 2014 Is: 857.3; Founders Include World-Renowned Physicist and Seasoned Business and IP Professionals July 24th, 2014

UCF Nanotech Spinout Developing Revolutionary Battery Technology: Power the Next Generation of Electronics with Carbon July 23rd, 2014

Nanobiotechnology

The channel that relaxes DNA: Relaxing DNA strands by using nano-channels: Instructions for use August 20th, 2014

Сalculations with Nanoscale Smart Particles August 19th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE