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Home > Press > HX Diagnostics and Nanogen Expand Collaboration

Abstract:
License and Development Agreement to Include Rapid, Point-of-Care Diagnostics for Additional Respiratory Infectious Diseases

HX Diagnostics and Nanogen Expand Collaboration

EMERYVILLE, CA | Posted on August 5th, 2008

HX Diagnostics, Inc. announced today that it has expanded its license and development agreement with Nanogen, Inc. (Nasdaq:NGEN) to include the development of additional rapid, point-of-care diagnostics for respiratory infectious diseases. As part of the three-year agreement, the companies will employ the same underlying technology used in their previously announced joint project, a diagnostic for the differential diagnosis of seasonal and pandemic influenza.

The companies are currently in the final stages of development on a highly sensitive diagnostic assay that can simultaneously detect multiple strains and subtypes of influenza, including avian influenza, with one simple and rapid test. The fluIDô Rapid Influenza Test is an easy-to-use, low cost device utilizing high affinity monoclonal antibodies and proprietary lateral flow technology from Nanogen. The technology is capable of detecting and differentiating multiple analytes in the sample. In pre-clinical trials, the assay demonstrated greater than 2 logs improvement in sensitivity over currently available assays.

The same proprietary lateral flow technology and device design will be used in the newly announced development programs. Once development is complete, HX Diagnostics will be granted exclusive commercial license to manufacture and market the resulting products upon regulatory approval.

"The expanded agreement with Nanogen gives us the opportunity to open up our potential market by providing full panels of diagnostics for respiratory illnesses," said Wendy Benson, president and chief executive officer of HX Diagnostics. "The rapid, accurate diagnosis of these infectious diseases will enable quicker treatment and recovery times for patients."

The development of the fluID test is supported in part by a 2006 grant from the U.S. Centers for Disease Control and Prevention as part of the U.S. government's efforts to strengthen its readiness for a potential influenza pandemic.

"Our R&D efforts on the CDC/HX avian influenza project have resulted in a next generation rapid diagnostic technology with breakthrough improvements in sensitivity and precision," said David Ludvigson, Nanogen's president and chief operating officer. "Expanding our relationship with HX Diagnostics to include additional respiratory disease diagnostics is a good way for Nanogen to leverage the technology and fulfill our mission of enabling better patient care by bringing to market easier and faster diagnostics."

####

About HX Diagnostics, Inc.
HX Diagnostics was founded in 2006 as part of the Kleiner Perkins Caufield & Byers Pandemic Preparedness and BioDefense Initiative with a mission to create improved diagnostics for emerging and infectious diseases. Through its collaborations with leading institutions around the world, HX Diagnostics is creating a diagnostic testing platform that can easily be tailored to enable rapid updates to the device kit as new strains of seasonal or potentially pandemic disease emerge.

Nanogen, Inc., develops diagnostic products that enable physicians to deliver improved patient care. Its products allow faster and easier diagnosis, treatment and monitoring of cardiovascular disease and a range of infectious diseases. The company's products include molecular diagnostic kits and reagents, and kits for rapid point-of-care testing. Nanogen has pioneered the development of biomarkers, molecular biology technologies and nanotechnology to bring better results to diagnostics and healthcare. For additional information please visit Nanogen's website at www.nanogen.com.

For more information, please click here

Contacts:
For HX Diagnostics:
Nicole Litchfield
415-793-6468

or
For Nanogen:
Kelly Gann
858-410-4667

Copyright © Business Wire 2008

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