Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Nanoparticles + Light = Dead Tumor Cells

Abstract:
Medical physicists at the University of Virginia have created a novel way to kill tumor cells using nanoparticles and light. The technique, devised by Wensha Yang, an instructor in radiation oncology at the University of Virginia, and colleagues Ke Sheng, Paul W. Read, James M. Larner, and Brian P. Helmke, employs quantum dots.

Nanoparticles + Light = Dead Tumor Cells

College Park, MD | Posted on July 29th, 2008

Medical physicists at the University of Virginia have created a novel way to kill tumor cells using nanoparticles and light. The technique, devised by Wensha Yang, an instructor in radiation oncology at the University of Virginia, and colleagues Ke Sheng, Paul W. Read, James M. Larner, and Brian P. Helmke, employs quantum dots. Quantum dots are semiconductor nanostructures, 25 billionths of a meter in diameter, which can confine electrons in three dimensions and emit light when exposed to ultraviolet radiation.

Yang and his colleagues realized that quantum dots also give off light when exposed to megavoltage x-rays, such as those used in cancer radiotherapy. That property, the scientists realized, makes quantum dots an ideal mediator in therapies employing light-activated compounds to treat cancer.

A compound called Photofrin is the only photosensitizer currently approved by the FDA. Photofrin is absorbed by cancer cells and, upon exposure to light, becomes active and kills cells. It is currently used to treat certain kinds of shallowly located tumors, but Yang and his colleagues realized that combing Photofrin with quantum dots could create an efficient method to kill even deeply seated cancer cells. Upon exposure to high doses of radiation, the dots become luminescent and emit light; that light triggers the cancer-killing activity of the Photofrin. In theory, the process, which so far has been studied only in cancer cells grown in culture, could work on tumors located too deep within the body to be reached by an external light source.

To prevent normal tissues from being affected by the treatment, the toxicity of the quantum dot-Photofrin conjugate is only activated when radiation is applied. Also, the area to be treated is targeted with conformal radiation, which is delivered with high precision within the three-dimensional contours of the tumor, with minimal spillover to surrounding healthy tissues. As a result, Yang says, "the toxicity of the drug is substantially lower in the lower radiation dose area" outside the boundaries of the tumor. In tests on human lung carcinoma cells, the process resulted in a 2-6 times lower tumor cell survival compared to radiation alone, but with minimal toxicity to nearby cells.

Yang will describe the technique in his talk, "Enhanced Energy Transfer From Mega-Voltage Radiation to the Tumor Cell Killing Singlet Oxygen by Semiconductive Nanoparticles," on Tuesday, July 29, during the 50th annual meeting of the American Association of Physicists in Medicine (AAPM), the largest medical physics association in the world. The meeting takes place from July 27 to July 31, in Houston, Texas.

RELATED LINKS
- AAPM home page: www.aapm.org
- Abstracts and search form www.aapm.org/meetings/08AM/MeetingProgram.asp
- Press Guide www.aapm.org/meetings/08AM/VirtualPressRoom/
- Background article about how medical physics has revolutionized medicine:
www.newswise.com/articles/view/538208/

HOW TO COVER THE MEETING
Reporters who would like to attend the meeting in person should fill out the press registration form on the AAPM Virtual Press Room. See:
www.aapm.org/meetings/08AM/VirtualPressRoom/documents/pressregform.pdf.

Reporters who would like to cover the conference remotely will find releases and articles on the Virtual Press Room highlighting many of the interesting and important talks presented at the meeting. Even if you can't make it to Houston, the Virtual Press Room will make it possible to write stories about the meeting from your desk.

####

About American Institute of Physics
The American Association of Physicists in Medicine (AAPM) is a scientific, educational, and professional nonprofit organization whose mission is to advance the application of physics to the diagnosis and treatment of human disease. The association encourages innovative research and development, helps disseminate scientific and technical information, fosters the education and professional development of medical physicists, and promotes the highest quality medical services for patients. In 2008, AAPM will celebrate its 50th year of serving patients, physicians, and physicists.

For more information, please click here

Contacts:
Jason Socrates Bardi
American Institute of Physics,
301-209-3091 (office)
858-775-4080 (cell)


Jeff Limmer
AAPM Media Relations Subcommittee Chair

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Industrial Nanotech, Inc. to Publish PCAOB Audited Financials July 31st, 2014

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Pressure probing potential photoelectronic manufacturing compound July 31st, 2014

Nanomedicine

Arrowhead to Report Fiscal 2014 Third Quarter Financial Results- Conference Call Scheduled for Tuesday, August 12, 2014 - July 31st, 2014

New imaging agent provides better picture of the gut July 30th, 2014

Zenosense, Inc. July 29th, 2014

Optimum inertial design for self-propulsion: A new study investigates the effects of small but finite inertia on the propulsion of micro and nano-scale swimming machines July 29th, 2014

Discoveries

Study finds physical link to strange electronic behavior: Neutron measurements offer new clues about iron-based superconductor July 31st, 2014

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Pressure probing potential photoelectronic manufacturing compound July 31st, 2014

Announcements

Industrial Nanotech, Inc. to Publish PCAOB Audited Financials July 31st, 2014

Nanostructured metal-oxide catalyst efficiently converts CO2 to methanol: Highly reactive sites at interface of 2 nanoscale components could help overcome hurdle of using CO2 as a starting point in producing useful products July 31st, 2014

Carnegie Mellon Chemists Create Nanofibers Using Unprecedented New Method July 31st, 2014

Pressure probing potential photoelectronic manufacturing compound July 31st, 2014

Events/Classes

Arrowhead to Report Fiscal 2014 Third Quarter Financial Results- Conference Call Scheduled for Tuesday, August 12, 2014 - July 31st, 2014

FLAG-ERA and TNT2014 join efforts: Graphene Networking at its higher level in Barcelona: Encourage the participation in a joint transnational call July 30th, 2014

FEI Unveils New Solutions for Faster Time-to-Analysis in Metals Research July 30th, 2014

WITec to host the 11th Confocal Raman Imaging Symposium from September 29th - October 1st in Ulm, Germany July 28th, 2014

Quantum Dots/Rods

Researchers create quantum dots with single-atom precision June 30th, 2014

New Los Alamos Approach May Be Key to Quantum Dot Solar Cells With Real Gains in Efficiency: Nanoengineering Boosts Carrier Multiplication in Quantum Dots June 19th, 2014

MIPT-based researcher predicts new state of matter June 17th, 2014

Technology using microwave heating may impact electronics manufacture June 10th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE