Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Nanoparticle Research in Review of Ophthalmology

Sanku Mallik, associate professor of pharmaceutical sciences at North Dakota State University, Fargo, conducts nanoparticle research which appears in the July issue of Review of Ophthalmology.
Sanku Mallik, associate professor of pharmaceutical sciences at North Dakota State University, Fargo, conducts nanoparticle research which appears in the July issue of Review of Ophthalmology.

Abstract:
While nanotechnology is being used in everything from paints to car exteriors, clothing and cosmetics, research is also underway using the technology to discover medical breakthroughs. Nanoparticle research by Professor Sanku Mallik and his group at North Dakota State University, Fargo, appears in the July issue of the Review of Ophthalmology in the article "Nanoparticles: Into the New Frontier."

Nanoparticle Research in Review of Ophthalmology

Fargo, ND | Posted on July 17th, 2008

www.revophth.com/index.asp?page=1_13901.htm

The article by senior editor Christopher Kent notes that cutting-edge work is being done in North Dakota, Oklahoma and Florida. The promise of such research includes finding treatments for eye diseases such as glaucoma and macular degeneration. Sanku Mallik, associate professor of pharmaceutical sciences at NDSU, conducts research that uses a nanoparticle called nanoceria as a drug delivery device. It is made of cerium oxide molecules. The brain-blood barrier can prevent medicines from reaching their therapeutic targets, but nanoparticles are so small they are capable of crossing the brain-blood barrier. Quoted in the article, Mallik notes, "So far, nanoceria appears to be nontoxic, but the drugs we attach to the particle might be toxic, so targeting molecules are necessary. These particles can also be used for imaging; we can attach molecules that can be made to glow after they reach targets such as cancer cells."

So far, the research of Mallik and his associates has been conducted in a controlled environment outside of a living organism and is in its initial stages. Researchers must ensure that the particles are water-soluble for effective delivery and less irritation to the cornea. Glaucoma is the leading cause of blindness if left untreated, according to the Glaucoma Research Foundation. An estimated four million Americans have glaucoma but only half of them know it, according to Prevent Blindness America. Minnesota Twins center fielder Kirby Puckett (1960-2006) was forced to retire due to loss of vision in one eye from glaucoma. Age-related macular degeneration is the leading cause of visual impairment and blindness in Americans older than 50, affecting more than two million people, according to the American Academy of Opththalmology.

The pharmaceutical research of Mallik's team includes attaching anti-cancer drugs to the nanoparticles and targeting molecules so particles only enter cells that are in need of treatment. Nanotechnology is often defined as the science of the extremely small. A nanometer, for example, is a hundred-thousandth of the thickness of a human hair, or one-billionth of a meter.

Mallik recently received a five-year, $1.46 million grant from the National Institutes of Health National Cancer Institute. D. K. Srivastava, professor of biochemistry and molecular biology at NDSU, is the co-investigator on this award. It relies on the complementary scientific expertise of Mallik and Srivastava. The grant will allow the investigators to prepare selective, "multi-prong" inhibitors for matrix metalloproteinases using lipid-based nanoparticles. They also will use the nanoparticles for isozyme-selective detection of these enzymes.

Mallik received his bachelor's degree in chemistry from the Indian Institute of Technology, Kharagpur, India, and his doctorate degree in organic chemistry at Case Western Reserve University, Cleveland, Ohio. He completed post-doctoral work at the California Institute of Technology, Pasadena, Calif. He is a past recipient of a National Science Foundation CAREER award, which recognizes and supports the early career-development activities of scholars who are likely to become the academic leaders of the 21st century. Information about Dr. Mallik's research is available at pharmsci.ndsu.nodak.edu/facstaff/mallik/research.htm

####

For more information, please click here

Contacts:
Carol Renner
701-231-5174

Copyright © Newswise

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Chemical trickery corrals 'hyperactive' metal-oxide cluster December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Nanomedicine

Arrowhead Pharmaceuticals to Webcast Fiscal 2016 Year End Results December 7th, 2016

Fast, efficient sperm tails inspire nanobiotechnology December 5th, 2016

Journal Nanotechnology Progress International (JONPI) Volume 6, issue 2 coming out soon! December 5th, 2016

UTSA study describes new minimally invasive device to treat cancer and other illnesses: Medicine diffusion capsule could locally treat multiple ailments and diseases over several weeks December 3rd, 2016

Discoveries

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

Announcements

Keeping electric car design on the right road: A closer look at the life-cycle impacts of lithium-ion batteries and proton exchange membrane fuel cells December 9th, 2016

Further improvement of qubit lifetime for quantum computers: New technique removes quasiparticles from superconducting quantum circuits December 9th, 2016

Researchers peer into atom-sized tunnels in hunt for better battery: May improve lithium ion for larger devices, like cars December 8th, 2016

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D: Up-close, real-time, chemical-sensitive 3-D imaging offers clues for reducing cost/improving performance of catalysts for fuel-cell-powered vehicles and other applications December 8th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project