Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Quantum Rod System May Safely 'Sneak' Drugs, Diagnostics into Brain

This confocal microscope image of a blood-brain barrier model shows quantum rods bioconjugated with transferrin; the findings could lead to better treatment of neuronal disorders.
This confocal microscope image of a blood-brain barrier model shows quantum rods bioconjugated with transferrin; the findings could lead to better treatment of neuronal disorders.

Abstract:
System also can serve as "test kit" for evaluating new transporter molecules

Quantum Rod System May Safely 'Sneak' Drugs, Diagnostics into Brain

Buffalo, NY | Posted on July 16th, 2008

A unique nanoparticle system developed by University at Buffalo scientists takes advantage of the versatility of bioconjugated quantum rods to ferry novel diagnostic and therapeutic agents across the blood-brain barrier, according to recent in vitro findings.

Described in a paper published in Bioconjugate Chemistry, the system uses the rod-shaped semiconductor nanoparticles that are bioconjugated, or coupled, with biomolecules capable of crossing the blood-brain barrier.

The blood-brain barrier acts as a physiological "checkpoint" that selectively allows certain molecules in blood circulation to enter the brain. While it naturally evolved in order to protect the brain from invasion of various circulating toxins and other harmful molecules, the blood-brain barrier also serves as a major impediment to the brain-specific delivery of various diagnostic/therapeutic molecules needed for combating various neuronal disorders.

The quantum rod system the UB researchers developed has the potential to simultaneously and non-invasively deliver diagnostic and therapeutic agents targeted to a wide variety of neurological diseases as well as obesity and drug addiction, according to Paras N. Prasad, Ph.D., executive director of the UB Institute for Lasers, Photonics and Biophotonics and SUNY Distinguished Professor in the Department of Chemistry, who led the UB team.

"These brain-specific nanoparticle systems represent a significant improvement over commonly used, highly-invasive methods of delivering active molecules into the brain, most of which rely on direct injection," he said.

The UB team, together with colleagues from Buffalo General Hospital, has developed a simple method for linking quantum rods to the iron-transporting protein, transferrin and other biomolecules, which routinely pass through the blood-brain barrier.

"Our findings unfold a new dimension in blood-brain barrier transport using inorganic nanoparticles, which are structurally robust and demonstrate the potential to transport multiple agents across this physiological barrier," said Indrajit Roy, Ph.D., deputy director for biophotonics at the UB institute. "This system allows the nanoparticles and the multiple therapeutic and imaging agents they carry to 'sneak' safely across the barrier and into the brain. It's a Trojan horse approach."

The functionalized quantum rods proved to have very low toxicity, according to Ken-Tye Yong, Ph.D., postdoctoral research associate in the UB institute, providing additional evidence that when linked to drug molecules, they could make very suitable treatment probes for diseases of the brain.

The new nanoparticle platform could provide scientists with a kind of window on the blood-brain barrier, enhancing what they know about it and allowing them to view non-invasively in real-time how imaging and therapeutic agents affect the brain.

The quantum rod system also serves as the basis of a blood-brain barrier-crossing test kit the UB researchers are developing.

The test kit would enable scientists to competitively evaluate which molecules would most efficiently transport diagnostic and therapeutic agents across the blood-brain barrier by exploiting the ability of quantum rods to emit light in different colors, depending on their size.

The research is closely aligned with the strategic strength in integrated nanostructured systems identified in the UB 2020 strategic planning process.

In addition to Prasad, Roy and Yong, co-authors included Gaixia Xu, Ph.D., former postdoctoral associate, and Hong Ding, Ph.D., postdoctoral associate, both of the UB Institute for Lasers, Photonics and Biophotonics; Supriya D. Mahajan, Ph.D., research assistant professor in the Department of Medicine in the UB School of Medicine and Biomedical Sciences and at Buffalo General Hospital, and Stanley A. Schwartz, M.D., Ph.D., UB professor of Medicine, Pediatrics and Microbiology and director of the Division of Allergy, Immunology and Rheumatology in the Department of Medicine at Buffalo General Hospital.

This research was supported by the John R. Oishei Foundation and by UB's New York State Center of Excellence in Bioinformatics and Life Sciences.

####

About University at Buffalo
The University at Buffalo is a premier research-intensive public university, a flagship institution in the State University of New York system and its largest and most comprehensive campus. UB's more than 28,000 students pursue their academic interests through more than 300 undergraduate, graduate and professional degree programs. Founded in 1846, the University at Buffalo is a member of the Association of American Universities.

For more information, please click here

Contacts:
Ellen Goldbaum

716-645-5000 ext 1415

Copyright © University at Buffalo

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New Method Uses DNA, Nanoparticles and Top-Down Lithography to Make Optically Active Structures: Technique could lead to new classes of materials that can bend light, such as for those used in cloaking devices January 18th, 2018

Arrowhead Pharmaceuticals Announces Pricing of Underwritten Public Offering of Common Stock January 18th, 2018

Leti to Demo New Curving Technology at Photonics West that Improves Performance of Optical Components January 18th, 2018

Arrowhead Pharmaceuticals Announces Proposed Underwritten Offering of Common Stock January 17th, 2018

Nanomedicine

Arrowhead Pharmaceuticals Announces Pricing of Underwritten Public Offering of Common Stock January 18th, 2018

Leti to Demo New Curving Technology at Photonics West that Improves Performance of Optical Components January 18th, 2018

Ultra-thin optical fibers offer new way to 3-D print microstructures: Novel approach lays groundwork for using 3-D printing to repair tissue in the body January 17th, 2018

Arrowhead Pharmaceuticals Announces Proposed Underwritten Offering of Common Stock January 17th, 2018

Discoveries

New Method Uses DNA, Nanoparticles and Top-Down Lithography to Make Optically Active Structures: Technique could lead to new classes of materials that can bend light, such as for those used in cloaking devices January 18th, 2018

Nanowrinkles could save billions in shipping and aquaculture Surfaces inspired by carnivorous plants delay degradation by marine fouling January 17th, 2018

Ultrathin black phosphorus for solar-driven hydrogen economy: Osaka University researchers use sunlight to make hydrogen with a new nanostructured catalyst based on nanosheets of black phosphorus and bismuth vanadate January 17th, 2018

Ultra-thin optical fibers offer new way to 3-D print microstructures: Novel approach lays groundwork for using 3-D printing to repair tissue in the body January 17th, 2018

Announcements

New Method Uses DNA, Nanoparticles and Top-Down Lithography to Make Optically Active Structures: Technique could lead to new classes of materials that can bend light, such as for those used in cloaking devices January 18th, 2018

Arrowhead Pharmaceuticals Announces Pricing of Underwritten Public Offering of Common Stock January 18th, 2018

Leti to Demo New Curving Technology at Photonics West that Improves Performance of Optical Components January 18th, 2018

Arrowhead Pharmaceuticals Announces Proposed Underwritten Offering of Common Stock January 17th, 2018

Quantum Dots/Rods

Tweaking quantum dots powers-up double-pane solar windows: Engineered quantum dots could bring down the cost of solar electricity January 2nd, 2018

Quantum communications bend to our needs: By changing the wavelengths of entangled photons to those used in telecommunications, researchers see quantum technology take a major leap forward September 28th, 2017

Band Gaps, Made to Order: Engineers create atomically thin superlattice materials with precision September 26th, 2017

New approach on research and design for CQD catalysts in World Scientific NANO August 2nd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project