Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > New ORNL Process Brings Nanoparticles Into Focus

Abstract:
Scientists can study the biological impacts of engineered nanomaterials on cells within the body with greater resolution than ever because of a procedure developed by researchers at the Department of Energy's Oak Ridge National Laboratory.

New ORNL Process Brings Nanoparticles Into Focus

Oak Ridge, TN | Posted on July 1st, 2008

The method, detailed in the current issue of Nature Nanotechnology, uses scanning near-field ultrasonic holography to clearly see nanoparticles residing within cells of laboratory mice that had inhaled single-walled carbon nanohorns. Nanohorns are short, horn-shaped tubular structures capped with a conical tip.

"While carbon-based materials have countless potential uses, we need to know how they interact within a cell - and whether they are able to penetrate cells," said Laurene Tetard, lead author and a member of ORNL's Biosciences Division. "We found that these nanohorns can indeed get into cells."

With this new tool, researchers will be able to determine whether a cell's shape changes because of nanomaterials such as the nanohorns used for this study. Tetard and co-authors expect this work to be of significant benefit to scientists studying drug delivery systems, nanotoxicology and interactions between engineered nanomaterials and biological systems.

"The rising commercial use of engineered nanoparticles and the ensuing need for large-scale production pose a risk of unintended human exposure that may impact health," the authors wrote. "Central to this issue is the ability to determine the fate of nanoparticles in biological systems and in more details their route after inhalation."

In contrast to conventional imaging techniques, scanning near-field ultrasonic holography provides a detailed look inside a cell, providing nanometer resolution.

"Conventional atomic force microscopy using a cantilever tip can only probe the surface of a specimen, making it difficult to analyze structures that are inside a cell," Tetard said. "Our method benefits from all of the advantages of a standard atomic force microscope but provides access to some of the features buried inside the cell."

Ultimately, this new imaging capability could help advance the field of nanoparticles-cell interactions. In addition to the high-resolution subsurface imaging and localization of nanoparticles in biological samples, scanning near-field ultrasonic holography allows for minimal sample preparation and requires no labeling with radioisotopes. The technique also offers relatively high throughput sample analysis, which enables researchers to image many cells quickly.

"The scanning near-field ultrasonic holography method should be especially useful for determining the efficacy of cell type-specific drug targeting, which is a critical goal for medical uses of nanomaterial," wrote the authors, who expect their results to help resolve critical questions about the fate and potential toxicity of nanoparticles within the body.

Co-authors of the paper, titled "Imaging nanoparticles in cells by nanomechanical holography," are Ali Passian, Katherine Venmar, Rachel Lynch, Brynn Voy and Thomas Thundat of ORNL and Gajendra Shekhawat and Vinayak Dravid of Northwestern University. Researchers at ORNL's Center for Nanophase Materials Sciences provided nanohorns for this work.

Funding was provided by the Department of Energy Office of Science, Biological and Environmental Research and by the Laboratory Directed Research and Development program. UT-Battelle manages Oak Ridge National Laboratory for the Department of Energy.

####

About ORNL
As we celebrate ORNL's historical achievements, our challenge is to build on Alvin Weinberg's notion of a laboratory whose mission evolves and strengthens over time. To that end, we continue to build on ORNL's historic competencies in energy, life sciences, neutron sciences and advanced materials while adding new research missions in the areas of national security and high-performance computing. Equally important, we are literally rebuilding ORNL by undertaking a $300-million modernization program that will maintain our laboratory as one of the world's leading scientific research centers.

For more information, please click here

Contacts:
Ron Walli
Communications and External Relations
865.576.0226

Copyright © ORNL

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New Biological Nano-Fertilizers Presented in Iran as Appropriate Replacements for Chemical Fertilizers April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Imaging

Combined effort for structural determination April 15th, 2015

JPK reports on the use of the NanoWizardŽ 3 AFM system at the Hebrew University of Jerusalem April 14th, 2015

Deben reports on the research of Dr Sunita Ho from UCSF using a CCT500 tensile stage to study the behaviour of dental materials April 14th, 2015

The Casiraghi Group, located at the University of Manchester's NanoScience and Spectroscopy Laboratory, use Raman in the study of graphene April 14th, 2015

Discoveries

Optical resonance-based biosensors designed for medical applications April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Protein Building Blocks for Nanosystems: Scientists develop method for producing bio-based materials with new properties April 17th, 2015

Announcements

New Biological Nano-Fertilizers Presented in Iran as Appropriate Replacements for Chemical Fertilizers April 18th, 2015

Iranian Foodstuff, Agricultural Industries Welcome Nanotechnology Packaging Bags April 18th, 2015

Nanocomposites Play Effective Role in Production of Smart Fibers April 18th, 2015

Dais Analytic Corporation Appoints Eliza Wang to Board of Directors: Company's Newest Director Brings Expertise in Commercial and Legal Matters Both in the United States and China; Joins on the Heels of Successful Business Development Trade Mission to China April 18th, 2015

Safety-Nanoparticles/Risk management

MIPT researchers put safety of magic anti-cancer bullet to test April 6th, 2015

NNI Publishes Workshop Report Assessing the Status of EHS Risk Science: Report examines progress three years after the release of the 2011 NNI EHS Research Strategy March 23rd, 2015

Are current water treatment methods sufficient to remove harmful engineered nanoparticle? March 10th, 2015

More study needed to clarify impact of cellulose nanocrystals on health: Few studies explore toxicity of cellulose nanocrystals March 10th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE