Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Abstract:
Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

ROANOKE, VA | Posted on June 25th, 2008

Researchers from Luna nanoWorks, a division of Luna Innovations Incorporated, and the Washington University School of Medicine co-authored a paper titled "Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging Contrast" that was published in the peer-reviewed Journal of Medicinal Chemistry. The paper describes a new contrast agent in which gadolinium is encapsulated within an extremely stable carbon nanosphere, thus allowing for safe, extended residence within the body. The new compounds may be used to visualize tissue architecture in vivo using standard Magnetic Resonance Imaging (MRI) techniques. Luna's HYDROCHALARONE™ molecules have initially proven to be more effective at enhancing images and are potentially safer than current gadolinium-containing contrast agents, which have been associated with health problems.

In today's agents, the gadolinium is formulated in a chelate to prevent toxicity. The chelate binds around the gadolinium, preventing toxicity. The chelate agent is designed to be in the body for a short period of time, and is cleansed through renal elimination. In kidney disease, the cleansing system slows down, allowing the chelate and the gadolinium to separate, which exposes the patient to the toxic metal molecule.

Luna's HYDROCHALARONE™ was selected for preclinical studies and collaboration with National Cancer Institute's Nanotechnology Characterization Laboratory. "The goal of Luna's product development effort with the HYDROCHALARONE™ is using it as a fundamental building block that may generate a portfolio of novel imaging agents targeted to reveal diagnostic information specific for a variety of different diseases, such as cancer tumors, sites of inflammation and plaque related to coronary artery diseases, as announced in our previous press release," said Robert Lenk, President of Luna's nanoWorks Division and an author on the paper.

The U.S. Food and Drug Administration (FDA) has been reviewing reports about patients who have developed a new disease after receiving a chelate-based contrast agent. This debilitating disease, known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD), may affect the skin, muscles and internal organs and can cause death. The FDA has issued a black-box warning to heighten awareness about the risk of NSF/NFD, particularly in patients with kidney and liver problems.

The Journal of Medicinal Chemistry is a publication of the American Chemical Society that focuses on original research dealing with chemical-biological relationships, mainly the bond between molecular structure and biological activity. The paper can be downloaded at the following link: pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/asap/abs/jm800521j.html.

####

For more information, please click here

Contacts:
Karin Clark
540-769-8446

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

Chemistry

Chains of nanogold – forged with atomic precision September 23rd, 2016

Carbon-coated iron catalyst structure could lead to more-active fuel cells September 15th, 2016

Researchers build world's largest database of crystal surfaces and shapes September 14th, 2016

On-surface chemistry leads to novel products: On-surface chemical Reactions can lead to novel chemical compounds not yet synthesized by solution chemistry. September 13th, 2016

Nanomedicine

Fighting cancer with sticky nanoparticles September 27th, 2016

Gold nanoparticles conjugated quercetin inhibits epithelial-mesenchymal transition, angiogenesis and invasiveness via EGFR/VEGFR-2 mediated pathway in breast cancer September 27th, 2016

Tattoo therapy could ease chronic disease: Rice-made nanoparticles tested at Baylor College of Medicine may help control autoimmune diseases September 23rd, 2016

BBI Solutions launches innovative conjugate blocking technology that enhances signal intensity for lateral flow immunoassays September 20th, 2016

Announcements

Innovation in Nanotechnology is Focus of Symposium: Annual event brings international experts to Northwestern Oct. 6 September 29th, 2016

Cambrios at CEATEC - Japan 2016 September 29th, 2016

Picosun patents ALD nanolaminate to prevent electronics from overheating September 28th, 2016

Leti and Taiwanese Tech Organizations Sponsoring Workshop in Taipei on MEMS, IoT, Smart Lighting Applications, System Reliability & Security September 28th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic