Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Abstract:
Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

ROANOKE, VA | Posted on June 25th, 2008

Researchers from Luna nanoWorks, a division of Luna Innovations Incorporated, and the Washington University School of Medicine co-authored a paper titled "Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging Contrast" that was published in the peer-reviewed Journal of Medicinal Chemistry. The paper describes a new contrast agent in which gadolinium is encapsulated within an extremely stable carbon nanosphere, thus allowing for safe, extended residence within the body. The new compounds may be used to visualize tissue architecture in vivo using standard Magnetic Resonance Imaging (MRI) techniques. Luna's HYDROCHALARONE™ molecules have initially proven to be more effective at enhancing images and are potentially safer than current gadolinium-containing contrast agents, which have been associated with health problems.

In today's agents, the gadolinium is formulated in a chelate to prevent toxicity. The chelate binds around the gadolinium, preventing toxicity. The chelate agent is designed to be in the body for a short period of time, and is cleansed through renal elimination. In kidney disease, the cleansing system slows down, allowing the chelate and the gadolinium to separate, which exposes the patient to the toxic metal molecule.

Luna's HYDROCHALARONE™ was selected for preclinical studies and collaboration with National Cancer Institute's Nanotechnology Characterization Laboratory. "The goal of Luna's product development effort with the HYDROCHALARONE™ is using it as a fundamental building block that may generate a portfolio of novel imaging agents targeted to reveal diagnostic information specific for a variety of different diseases, such as cancer tumors, sites of inflammation and plaque related to coronary artery diseases, as announced in our previous press release," said Robert Lenk, President of Luna's nanoWorks Division and an author on the paper.

The U.S. Food and Drug Administration (FDA) has been reviewing reports about patients who have developed a new disease after receiving a chelate-based contrast agent. This debilitating disease, known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD), may affect the skin, muscles and internal organs and can cause death. The FDA has issued a black-box warning to heighten awareness about the risk of NSF/NFD, particularly in patients with kidney and liver problems.

The Journal of Medicinal Chemistry is a publication of the American Chemical Society that focuses on original research dealing with chemical-biological relationships, mainly the bond between molecular structure and biological activity. The paper can be downloaded at the following link: pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/asap/abs/jm800521j.html.

####

For more information, please click here

Contacts:
Karin Clark
540-769-8446

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Nanometrics Reports Second Quarter 2016 Financial Results July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Chemistry

New reaction for the synthesis of nanostructures July 21st, 2016

Pushing a single-molecule switch: An international team of researchers from Donostia International Physics Center, Fritz-Haber Institute of the Max Planck Society, University of Liverpool, and the Polish Academy of Sciences has shown a new way to operate a single-molecule switch July 19th, 2016

Rice's 'antenna-reactor' catalysts offer best of both worlds: Technology marries light-harvesting nanoantennas to high-reaction-rate catalysts July 18th, 2016

Researchers improve catalyst efficiency for clean industries: Method reduces use of expensive platinum July 8th, 2016

Nanomedicine

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

Announcements

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

Nanometrics Reports Second Quarter 2016 Financial Results July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic