Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Abstract:
Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

Luna nanoWorks' Next-Generation MRI Contrast Agent Breakthrough Published in Journal of Medicinal Chemistry

ROANOKE, VA | Posted on June 25th, 2008

Researchers from Luna nanoWorks, a division of Luna Innovations Incorporated, and the Washington University School of Medicine co-authored a paper titled "Hydrochalarones: A Novel Endohedral Metallofullerene Platform for Enhancing Magnetic Resonance Imaging Contrast" that was published in the peer-reviewed Journal of Medicinal Chemistry. The paper describes a new contrast agent in which gadolinium is encapsulated within an extremely stable carbon nanosphere, thus allowing for safe, extended residence within the body. The new compounds may be used to visualize tissue architecture in vivo using standard Magnetic Resonance Imaging (MRI) techniques. Luna's HYDROCHALARONE™ molecules have initially proven to be more effective at enhancing images and are potentially safer than current gadolinium-containing contrast agents, which have been associated with health problems.

In today's agents, the gadolinium is formulated in a chelate to prevent toxicity. The chelate binds around the gadolinium, preventing toxicity. The chelate agent is designed to be in the body for a short period of time, and is cleansed through renal elimination. In kidney disease, the cleansing system slows down, allowing the chelate and the gadolinium to separate, which exposes the patient to the toxic metal molecule.

Luna's HYDROCHALARONE™ was selected for preclinical studies and collaboration with National Cancer Institute's Nanotechnology Characterization Laboratory. "The goal of Luna's product development effort with the HYDROCHALARONE™ is using it as a fundamental building block that may generate a portfolio of novel imaging agents targeted to reveal diagnostic information specific for a variety of different diseases, such as cancer tumors, sites of inflammation and plaque related to coronary artery diseases, as announced in our previous press release," said Robert Lenk, President of Luna's nanoWorks Division and an author on the paper.

The U.S. Food and Drug Administration (FDA) has been reviewing reports about patients who have developed a new disease after receiving a chelate-based contrast agent. This debilitating disease, known as Nephrogenic Systemic Fibrosis or Nephrogenic Fibrosing Dermopathy (NSF/NFD), may affect the skin, muscles and internal organs and can cause death. The FDA has issued a black-box warning to heighten awareness about the risk of NSF/NFD, particularly in patients with kidney and liver problems.

The Journal of Medicinal Chemistry is a publication of the American Chemical Society that focuses on original research dealing with chemical-biological relationships, mainly the bond between molecular structure and biological activity. The paper can be downloaded at the following link: pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/asap/abs/jm800521j.html.

####

For more information, please click here

Contacts:
Karin Clark
540-769-8446

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Band Gaps, Made to Order: Engineers create atomically thin superlattice materials with precision September 26th, 2017

Assembly of nanoparticles proceeds like a zipper: Viruses and nanoparticles can be assembled into processable superlattice wires according to scientists from Aalto University Finland September 25th, 2017

Enhancing the sensing capabilities of diamonds with quantum properties: A simple method can give diamonds the special properties needed for quantum applications such as sensing magnetic fields September 24th, 2017

Quantum twisted Loong confirms the physical reality of wavefunctions September 23rd, 2017

Chemistry

Copper catalyst yields high efficiency CO2-to-fuels conversion: Berkeley Lab scientists discover critical role of nanoparticle transformation September 20th, 2017

Chemical hot spots: Scanning tunneling microscopy measurements identify active sites on catalyst surfaces September 7th, 2017

More durable, less expensive fuel cells: University of Delaware researchers have developed a new technology that could speed up the commercialization of fuel cell vehicles September 5th, 2017

Research shows how DNA molecules cross nanopores: Study could inform biosensors, manufacturing, and more September 5th, 2017

Nanomedicine

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Arrowhead Hosts Investor & Analyst R&D Day to Introduce TRiM(TM) Platform and Lead RNAi-based Drug Candidates September 14th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Applications for the nanomedTAB are open until September 18th, 2017 September 13th, 2017

Announcements

Band Gaps, Made to Order: Engineers create atomically thin superlattice materials with precision September 26th, 2017

Assembly of nanoparticles proceeds like a zipper: Viruses and nanoparticles can be assembled into processable superlattice wires according to scientists from Aalto University Finland September 25th, 2017

Enhancing the sensing capabilities of diamonds with quantum properties: A simple method can give diamonds the special properties needed for quantum applications such as sensing magnetic fields September 24th, 2017

Quantum twisted Loong confirms the physical reality of wavefunctions September 23rd, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project