Nanotechnology Now

Our NanoNews Digest Sponsors
Heifer International

Wikipedia Affiliate Button

Home > Press > Quantum Rods Probe Blood-Brain Barrier

Abstract:
One of the chief difficulties in treating brain tumors involves getting potential tumor-killing drugs across the blood-brain barrier and into the brain. Now, researchers from a NCI Cancer Nanotechnology Platform Partnership at the University of Buffalo have used targeted quantum rods both to breach the blood-brain barrier and to study how such constructs move across this largely impermeable barrier. Paras Prasad, Ph.D., principal investigator of the SUNY-Buffalo Platform Partnership, led the research team that published results in the journal Bioconjugate Chemistry.

Quantum Rods Probe Blood-Brain Barrier

Bethesda , MD | Posted on June 16th, 2008

The investigators began their work by preparing red- and orange-emitting quantum rods made of cadmium selenide, cadmium sulfide, and zinc sulfide. They then attached an iron-transporting protein known as transferrin to the surface of the quantum rods. Transferrin binds to a complex protein known as the transferrin receptor. The blood-brain barrier contains large numbers of this receptor, and research has shown that it can act to transport biomolecules across the blood-brain barrier.

Because of the intense fluorescence exhibited by quantum rods, the investigators were able to image these markers as they bound to and moved across a cell-based model of the blood-brain barrier. In contrast, quantum rods lacking surface transferrin did not cross the model blood-brain barrier. One interesting finding from these experiments is that there appears to be a critical period that starts after 26 hours at which time transport is most efficient across the blood-brain barrier. The investigators note that the data from these experiments should help them design new nanoscale agents for ferrying anticancer drugs into the brain.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:


National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Bioconjugated Quantum Rods as Targeted Probes for Efficient Transmigration Across an In Vitro Blood-Brain Barrier.”

Related News Press

News and information

Nanobiotix Plans to Conduct Registered Public Offering in the United States January 17th, 2019

Power stations driven by light: More efficient solar cells imitate photosynthesis January 16th, 2019

Drilling speed increased by 20% – yet another upgrade in the oil & gas sector made possible by graphene nanotubes January 15th, 2019

Chirality in 'real-time' January 14th, 2019

Nanomedicine

Nanobiotix Plans to Conduct Registered Public Offering in the United States January 17th, 2019

Chirality in 'real-time' January 14th, 2019

Ultra-sensitive sensor with gold nanoparticle array January 9th, 2019

Arrowhead Pharmaceuticals Begins Dosing in Phase 1 Study of ARO-ANG3 for Treatment of Dyslipidemias and Metabolic Diseases January 7th, 2019

Discoveries

Power stations driven by light: More efficient solar cells imitate photosynthesis January 16th, 2019

Chirality in 'real-time' January 14th, 2019

Spintronics 'miracle material' put to the test: Physicists build devices using mineral perovskite January 11th, 2019

Cartilage could be key to safe 'structural batteries' January 11th, 2019

Announcements

Nanobiotix Plans to Conduct Registered Public Offering in the United States January 17th, 2019

Power stations driven by light: More efficient solar cells imitate photosynthesis January 16th, 2019

Drilling speed increased by 20% – yet another upgrade in the oil & gas sector made possible by graphene nanotubes January 15th, 2019

Chirality in 'real-time' January 14th, 2019

Quantum Dots/Rods

Machine learning helps improving photonic applications September 28th, 2018

A Novel Graphene Quantum Dot Structure Takes the Cake August 24th, 2018

Individual quantum dots imaged in 3-D for first time February 28th, 2018

Moving nanoparticles using light and magnetic fields January 25th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project