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Home > News > Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

June 15th, 2008

Human tumor nanoparticles induce apoptosis of pancreatic cancer cells

Abstract:
Using nanoparticles made from pieces of tumor cells, investigators from Aix-Marseille University in Marseille, France, have developed a new type of anticancer agent that appears to stop tumor cell growth and proliferation.

This research, led by Dominique Lombardo, Ph.D., and Alain Verine, Ph.D., presents the first evidence that tumor-derived nanoparticles can trigger tumor cell death.

Reporting its work in the FASEB Journal, the investigators began their study by harvesting pieces of tumor cell membrane that bud off from pancreatic cancer cells. These exosomes resemble lipid-based nanoparticles known as liposomes, but the exosomes are loaded with various tumor cell membrane proteins. After purifying the nanoparticles, the researchers administered them to tumor cells, triggering cell death at a level proportional to the amount of nanoparticles added to the cells. The nanoparticles had no effect when added to normal cells.

Source:
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