Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Oncologic and Triton BioSystems Merge to Form Aduro BioTech: Aduro to Focus on NT™ and TNT™ Systems for Solid Tumor Cancers

Abstract:
Two early stage cancer therapy companies, Oncologic and Triton BioSystems, have merged to create Aduro BioTech. Aduro, which is privately held, will be headquartered at the former Oncologic facility in Berkeley, California.

Oncologic and Triton BioSystems Merge to Form Aduro BioTech: Aduro to Focus on NT™ and TNT™ Systems for Solid Tumor Cancers

Berkeley, CA | Posted on June 2nd, 2008

Aduro will focus on the development of its proprietary and minimally invasive NT™ and TNT™ cancer therapies, which use patented iron oxide nano-particles to target and kill solid tumor cancers. The nano-particles are engineered to efficiently generate high levels of heat when exposed to an externally applied magnetic field, and this heat kills tumor cells without the toxicity or collateral damage that result from traditional chemotherapy or radiation treatments.

"There are several exciting aspects of the Aduro technology that we believe can offer significant improvements to current therapies," said Stephen T. Isaacs, CEO of Aduro. "We are developing a cancer therapy based on the low toxicity of iron oxide, which is an innocuous material currently used in a variety of medical applications. If successfully developed, the Aduro products will be an exceedingly important addition to the field of solid tumor cancer therapy."

According to the company, one of the major problems with current cancer therapy is the collateral damage to normal tissues, and that it's often not the failure of radiation or chemotherapeutic agent to kill the tumor that's the problem, but rather the inability to deliver a "knock-out" punch because of dose-limiting toxicity. The company believes that unlike radiation or chemotherapy, the Aduro NT™ and TNT™ particles will be innocuous until activation by an external (non-invasive) alternating magnetic field. Due to the low-toxicity of iron oxide and the targeting agents which guide the nano-particles to the tumor, Aduro believes its NT™ and TNT™ therapeutic products may be used at higher dose levels than current therapies, which in turn should provide significantly improved therapeutic outcomes.

Oncologic and Triton BioSystems Merge to Form Aduro BioTech

Mr. Isaacs said that the technology has been demonstrated to work in a murine (mouse) system with both direct and systemic infusions of the NT™ and TNT™ nano-particles. "We believe the NT™ (direct infusion) method is the shortest path to the clinic, and we hope to start a clinical trial for accessible head and neck cancer in 2009," Mr. Isaacs continued. "Our basic strategy is to be first to show direct clinical benefit with ‘thermal therapy' in humans, then to move on the more interesting systemic approach with the TNT™ method, which we believe holds promise for metastatic disease."

In 1991, Mr. Isaacs founded Cerus Corporation (NASD: CERS), where he served as CEO for fourteen years. During Isaacs' tenure, Cerus became a publicly traded company, entered several major corporate partnerships, raised over 250 million dollars, and brought its first product to market in Europe. He is joined by several seasoned cancer researchers, including Drs. Paul Chinn and Gary Braslawsky, who worked together at Biogen-Idec, where they led the development of Zevalin®, an FDA-approved radio-pharmaceutical used for the treatment of non-Hodgkin's lymphoma (a blood cancer).

Aduro BioTech simultaneously closed on its Series A financing round, which included a consortium of insiders and new investors. Terms of the financing were not disclosed.

© 2008 Aduro BioTech, Inc. TNT™ and NT™ are trademarks of Aduro; Zevalin®is a registered trademark of Cell Therapeutics, Inc.

####

For more information, please click here

Contacts:
Aduro BioTech
David S. Rose
510-848-4400 x101

Copyright © Business Wire 2008

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

VC/Funding/Angel financing/Loans/Leases/Crowdfunding

Forge Nano 2017: 1st Quarter Media Update April 20th, 2017

180 Degree Capital Corp. Announces the Start of Kevin Rendino as Chairman and Chief Executive Officer and Completion of its Transition to a Registered Closed-End Fund March 31st, 2017

Caught on camera -- chemical reactions 'filmed' at the single-molecule level March 22nd, 2017

Harris & Harris Group Issues Its Financial Statements as of December 31, 2016, Posts Its Annual Shareholder Letter, And Will Host a Conference Call for Shareholders on Friday, March 17, 2017 March 15th, 2017

Nanomedicine

Arrowhead Presents ARC-520 and ARC-521 Clinical Data at The International Liver Congress(TM) April 20th, 2017

Nano-SPEARs gently measure electrical signals in small animals: Rice University's tiny needles simplify data gathering to probe diseases, test drugs April 17th, 2017

Nanotubes that build themselves April 14th, 2017

Emergency Use Authorization for Gene-RADAR® Zika Virus Test: FDA Authorization for the Gene-RADAR® Zika Virus Test on the XPRIZE-Winning Gene-RADAR® Platform April 14th, 2017

Announcements

Two-dimensional melting of hard spheres experimentally unravelled after 60 years: First definitive experimental evidence of two-dimensional melting of hard spheres April 21st, 2017

National Conference on Nanomaterials, (NCN-2017) April 21st, 2017

NanoMONITOR shares its latest developments concerning the NanoMONITOR Software and the Monitoring stations April 21st, 2017

Nanomechanics, Inc. Unveils New Product at ICMCTF Show April 25th: Nanoindentation experts will launch the new Gemini that measures the interaction of two objects that are sliding across each other – not merely making contact April 21st, 2017

Acquisitions/Mergers/Splits

Bruker Announces Acquisition of Nanoindenting Leader Hysitron: Acquisition strengthens Bruker’s leading position in nanoanalysis and nanomechanical materials characterization January 24th, 2017

GLOBALFOUNDRIES Completes Acquisition of IBM Microelectronics Business: Transaction adds differentiating technologies, world-class technologists, and intellectual property July 1st, 2015

Entest BioMedical, Inc. in Discussions to Acquire Nanotechnology Delivery System for Cancer Therapy June 3rd, 2015

Evident Thermoelectrics Acquires GMZ Energy: Investment Accelerates Launch Of Evident's Thermoelectric Modules For Waste Heat May 20th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project