Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > R&D Profile: Drug-eluting Anodized Titanium Orthopedic Implants: T. Webster, Brown University

Nanotubes Under High Magnification, Courtesy of T. Webster, Brown University
Nanotubes Under High Magnification, Courtesy of T. Webster, Brown University

Abstract:
The average functional lifetime of orthopedic implants has been estimated to be less than 15 years. Few studies have focused on creating an orthopedic implant with multi-functional drug release to inhibit infection and wound inflammation events while increasing new bone formation.

R&D Profile: Drug-eluting Anodized Titanium Orthopedic Implants: T. Webster, Brown University

Boston, MA | Posted on May 22nd, 2008

R&D Overview Courtesy of Thomas Webster, Associate Professor, Division of Engineering, Brown University.

Dr. Webster is a featured speaker at next month's NSTI Nanotech conference, and will also lead the one-day workshop Biomaterials and Nanotechnology for Tissue Engineering Sunday, June 1.

In previous studies, titania nanotube arrays fabricated via anodization in dilute hydrofluoric acid were shown to increase bone growth compared to currently implanted titanium. In this study, these tubular structures were further utilized as novel prolonged-release drug delivery system. For this purpose, antibiotic drugs (penicillin and streptomycin) and an anti-inflammation drug (dexamethasone) were loaded into these nanotubular structures by either physical adsorption or electrochemical deposition. To mediate interactions between drug molecules and nanotube walls, anodized titanium nanotubes were modified by silanization to possess amine or methyl groups on their surface instead of OH groups. Results showed increased hydrophobicity of chemically modified titania nanotubes as well as improved drug loading efficiency on the more hydrophobic samples. These drug loaded substrates were soaked in phosphate buffered solution in a simulated body environment to determine drug release behavior. Buffer solution was collected and replaced every day. The eluted drug amounts were measured spectroscopically. Results showed prolonged drug releasing behavior from chemically modified nanotubes compared to conventional titanium substrates. In this manner, this study advances currently used titanium to possess drug release behavior which can improve orthopedic implant efficacy.

Since we have already demonstrated the in vitro efficacy of these anodized nanotubular contructs for releasing drugs (anti-bacterial, anti-inflammatory, and pro-bone growing) and promoting new bone growth, we are planning to conduct in vivo verification. Currently, we are planning to conduct animal studies in which currently implant materials are modified via anodization to possess such novel nanotubular structures to both release drugs and promote new bone growth.

####

About NSTI
The Nano Science and Technology Institute (NSTI) is chartered with the promotion and integration of nano and other advanced technologies through education, technology and business development. NSTI accomplishes this mission through its offerings of continuing education programs, scientific and business publishing and community outreach. NSTI produces the annual Nanotech conference and trade show, the most comprehensive international nanotechnology convention in the world. NSTI also produces the semi-annual Nanotech Venture, Nanotech Industrial Impact Workshop, Nano Impact Summit and the Nanotech Course Series in the US and Europe. NSTI was founded in 1997 as a result of the merger between various scientific societies, and is headquartered in Cambridge, Massachusetts with additional offices in California and Switzerland.

For more information, please click here

Contacts:
Sarah Wenning
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 901-4959
Fax: (925) 886-8461

Copyright © NSTI

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Nanotubes/Buckyballs

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Chromium-Centered Cycloparaphenylene Rings as New Tools for Making Functionalized Nanocarbons February 24th, 2015

Building tailor-made DNA nanotubes step by step: New, block-by-block assembly method could pave way for applications in opto-electronics, drug delivery February 23rd, 2015

Half spheres for molecular circuits: Corannulene shows promising electronic properties February 17th, 2015

Nanomedicine

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Announcements

UC research partnership explores how to best harness solar power March 2nd, 2015

Researchers turn unzipped nanotubes into possible alternative for platinum: Aerogel catalyst shows promise for fuel cells March 2nd, 2015

Important step towards quantum computing: Metals at atomic scale March 2nd, 2015

New Hopes for Treatment of Intestine Cancer by Edible Nanodrug March 2nd, 2015

Events/Classes

UC research partnership explores how to best harness solar power March 2nd, 2015

Imec, Holst Centre and Renesas Present World’s Lowest Power 2.4GHz Radio Chip for Bluetooth Low Energy March 1st, 2015

Imec Demonstrates Compact Wavelength-Division Multiplexing CMOS Silicon Photonics Transceiver March 1st, 2015

onic Present breakthrough in CMOS-based Transceivers for mm-Wave Radar Systems March 1st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE