Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > R&D Profile: Drug-eluting Anodized Titanium Orthopedic Implants: T. Webster, Brown University

Nanotubes Under High Magnification, Courtesy of T. Webster, Brown University
Nanotubes Under High Magnification, Courtesy of T. Webster, Brown University

Abstract:
The average functional lifetime of orthopedic implants has been estimated to be less than 15 years. Few studies have focused on creating an orthopedic implant with multi-functional drug release to inhibit infection and wound inflammation events while increasing new bone formation.

R&D Profile: Drug-eluting Anodized Titanium Orthopedic Implants: T. Webster, Brown University

Boston, MA | Posted on May 22nd, 2008

R&D Overview Courtesy of Thomas Webster, Associate Professor, Division of Engineering, Brown University.

Dr. Webster is a featured speaker at next month's NSTI Nanotech conference, and will also lead the one-day workshop Biomaterials and Nanotechnology for Tissue Engineering Sunday, June 1.

In previous studies, titania nanotube arrays fabricated via anodization in dilute hydrofluoric acid were shown to increase bone growth compared to currently implanted titanium. In this study, these tubular structures were further utilized as novel prolonged-release drug delivery system. For this purpose, antibiotic drugs (penicillin and streptomycin) and an anti-inflammation drug (dexamethasone) were loaded into these nanotubular structures by either physical adsorption or electrochemical deposition. To mediate interactions between drug molecules and nanotube walls, anodized titanium nanotubes were modified by silanization to possess amine or methyl groups on their surface instead of OH groups. Results showed increased hydrophobicity of chemically modified titania nanotubes as well as improved drug loading efficiency on the more hydrophobic samples. These drug loaded substrates were soaked in phosphate buffered solution in a simulated body environment to determine drug release behavior. Buffer solution was collected and replaced every day. The eluted drug amounts were measured spectroscopically. Results showed prolonged drug releasing behavior from chemically modified nanotubes compared to conventional titanium substrates. In this manner, this study advances currently used titanium to possess drug release behavior which can improve orthopedic implant efficacy.

Since we have already demonstrated the in vitro efficacy of these anodized nanotubular contructs for releasing drugs (anti-bacterial, anti-inflammatory, and pro-bone growing) and promoting new bone growth, we are planning to conduct in vivo verification. Currently, we are planning to conduct animal studies in which currently implant materials are modified via anodization to possess such novel nanotubular structures to both release drugs and promote new bone growth.

####

About NSTI
The Nano Science and Technology Institute (NSTI) is chartered with the promotion and integration of nano and other advanced technologies through education, technology and business development. NSTI accomplishes this mission through its offerings of continuing education programs, scientific and business publishing and community outreach. NSTI produces the annual Nanotech conference and trade show, the most comprehensive international nanotechnology convention in the world. NSTI also produces the semi-annual Nanotech Venture, Nanotech Industrial Impact Workshop, Nano Impact Summit and the Nanotech Course Series in the US and Europe. NSTI was founded in 1997 as a result of the merger between various scientific societies, and is headquartered in Cambridge, Massachusetts with additional offices in California and Switzerland.

For more information, please click here

Contacts:
Sarah Wenning
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 901-4959
Fax: (925) 886-8461

Copyright © NSTI

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

University of Tehran Researchers Invent Non-Enzyme Sensor to Detect Blood Sugar April 23rd, 2014

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell April 23rd, 2014

Study finds long-term survival of human neural stem cells transplanted into primate brain April 23rd, 2014

High-Performance, Low-Cost Ultracapacitors Built with Graphene and Carbon Nanotubes: Future devices based on technology could bridge gap between batteries and conventional capacitors in portable electronics and hybrid electric vehicles April 23rd, 2014

Nanotubes/Buckyballs

High-Performance, Low-Cost Ultracapacitors Built with Graphene and Carbon Nanotubes: Future devices based on technology could bridge gap between batteries and conventional capacitors in portable electronics and hybrid electric vehicles April 23rd, 2014

Amino-functionalized carbon nanotubes act as a carrier for nerve growth factor April 21st, 2014

Effects of Carbon Nanotubes Studied on Pregnant Mothers April 12th, 2014

Nanotech Business Review 2013-2014 April 9th, 2014

Nanomedicine

University of Tehran Researchers Invent Non-Enzyme Sensor to Detect Blood Sugar April 23rd, 2014

Gold nanoparticles help target, quantify breast cancer gene segments in a living cell April 23rd, 2014

QuantuMDx announce prototype handheld lab for 15 minute malaria diagnosis and drug resistance testing April 23rd, 2014

Study finds long-term survival of human neural stem cells transplanted into primate brain April 23rd, 2014

Announcements

Characterizing inkjet inks: Malvern Instruments presents new rheological research April 23rd, 2014

NanoSafe, Inc. announces the addition of the Labconco Protector® Glove Box to its NanoSafe Tested™ registry April 23rd, 2014

Study finds long-term survival of human neural stem cells transplanted into primate brain April 23rd, 2014

High-Performance, Low-Cost Ultracapacitors Built with Graphene and Carbon Nanotubes: Future devices based on technology could bridge gap between batteries and conventional capacitors in portable electronics and hybrid electric vehicles April 23rd, 2014

Events/Classes

Characterizing inkjet inks: Malvern Instruments presents new rheological research April 23rd, 2014

PETA science consortium to present hazard testing strategy at nanotoxicology meeting: High tech field ripe for use of sophisticated non-animal testing strategies April 22nd, 2014

National Space Society Congratulates SpaceX on the Success of CRS-3 and the First Flight of the Falcon 9R April 22nd, 2014

INSCX™ exchange to present Exchange trade reporting mechanism for engineered nanomaterials (NMs) to UK regulation agencies, insurers and upstream/downstream users April 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE