Nanotechnology Now

Our NanoNews Digest Sponsors







Heifer International

Wikipedia Affiliate Button


Home > Press > Chip-Based Device Measures Drug Resistance in Tumor Cells

Abstract:
Multiple drug resistance is a major cause of anticancer therapy failure. Most drug-resistance cancer cells develop this unfortunate characteristic due to a drug-pumping protein known as P-glycoprotein. Now, a team of investigators at Simon Fraser University in Burnaby, British Columbia, has developed a microfluidic chip that can trap individual cancer cells and investigate the ability of various pump-blocking drugs to overcome drug resistance. This new "lab-on-a-chip" device could prove useful for studying multiple drug resistance and for selecting the appropriate therapy for a given patient.

Chip-Based Device Measures Drug Resistance in Tumor Cells

Bethesda , MD | Posted on May 21st, 2008

Paul Li, Ph.D., and his colleagues developed the dime-size chip to select and retain individual cancer cells within a chamber that can be dosed with drugs loaded into an on-chip reservoir. An optical detection system, consisting of an inverted fluorescence microscope, enabled the researchers to measure drug influx and efflux in real time, before and after the cells were dosed with various pump inhibitors. In their current work, which appears in the journal Analytical Chemistry, the investigators studied the effects of the antipump drug verapamil on the net intake of the anticancer drug daunorubicin.

This work is detailed in the paper "Same-Single-Cell Analysis for the Study of Drug Efflux Modulation of Multidrug Resistant Cells Using a Microfluidic Chip." Investigators from the BC Cancer Research Center in Vancouver also participated in this study. An abstract of this paper is available at the journal's Web site.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

News and information

JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013

Imec and GLOBALFOUNDRIES collaborate to advance high-density memory technology: STT-MRAM offers enhanced performance and scalability for embedded and standalone applications May 21st, 2013

International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013

Rice unveils method for tailoring optical processors: Arranging nanoparticles in geometric patterns allows for control of light with light May 21st, 2013

Nanomedicine

Nanoparticle Delivers Large Protein Complex to Cancer Cell Nucleus May 20th, 2013

Protein 'Passport' Helps Nanoparticles Get Past Immune System May 20th, 2013

New Nanopore Sensor Simplifies Analysis of Methylated DNA May 20th, 2013

Elsevier Business Intelligence (EBI) to Host 'IN3 Medical Device 360 Boston,' June 24-26, 2013 May 20th, 2013

Discoveries

Rice unveils method for tailoring optical processors: Arranging nanoparticles in geometric patterns allows for control of light with light May 21st, 2013

Nanoparticle Harnesses Powerful Radiation Therapy for Cancer May 20th, 2013

Microneedle-Delivered Nanoparticles Boost Antitumor Vaccines May 20th, 2013

Competition in the Quantum World May 20th, 2013

Announcements

JPK reports on single molecule research at IISER Pune in India using AFM and CellHesion techniques May 21st, 2013

Imec and GLOBALFOUNDRIES collaborate to advance high-density memory technology: STT-MRAM offers enhanced performance and scalability for embedded and standalone applications May 21st, 2013

International survey supports need for built-in water protection on smartphones and tablets May 21st, 2013

Rice unveils method for tailoring optical processors: Arranging nanoparticles in geometric patterns allows for control of light with light May 21st, 2013

NanoNews-Digest
The latest news from around the world, FREE





  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More












ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project








abbigliamento uomo
Computer Accessories
© Copyright 1999-2013 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE