Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Multifunctional Nanoparticles Image, Target, and Treat Tumors

Abstract:
Encapsulating magnetic iron oxide nanoparticles within a silica shell has yielded a new multifunctional nanoparticle that has the potential to image, target, and treat tumors with water-insoluble anticancer drugs. A report of this work appears in the journal ACS Nano.

Multifunctional Nanoparticles Image, Target, and Treat Tumors

Bethesda , MD | Posted on May 21st, 2008


Back
Nanotech News


May 2008

Multifunctional Nanoparticles Image, Target, and Treat Tumors

Encapsulating magnetic iron oxide nanoparticles within a silica shell has yielded a new multifunctional nanoparticle that has the potential to image, target, and treat tumors with water-insoluble anticancer drugs. A report of this work appears in the journal ACS Nano.

Jeffery Zink, Ph.D., led a research team at the University of California, Los Angeles, that created the new nanoparticles, which contain an iron oxide nanoparticle core and a porous silica shell. The investigators coated the resulting nanoparticles with folic acid, a tumor targeting agent, and a fluorescent dye to enable optical imaging. Soaking the nanoparticles in a solvent containing either paclitaxel or camptothecin, both of which are poorly soluble in water and difficult to deliver to tumors as a result, resulted in significant drug loading through the pores in the silica shell. Tests showed that the drug-loaded nanoparticles were stable for at least 2 months.

Experiments with pancreatic cancer cells demonstrated that the targeted nanoparticles were taken up rapidly by cancer cells, whereas untargeted control nanoparticles were not. The researchers were able to quantify nanoparticle uptake using both MRI and optical spectroscopy thanks to the iron oxide nanoparticle core and fluorescent dyes, respectively. The targeted nanoparticles were also more toxic to the tumor cells than were untargeted nanoparticles.

This work, which was supported in part by the NCI, is detailed in the paper "Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery." An abstract of this paper is available at the journal's Web site.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

News and information

Scientific breakthrough in rechargeable batteries: Researchers from Singapore and Québec Team Up to Develop Next-Generation Materials to Power Electronic Devices and Electric Vehicles February 28th, 2015

First detailed microscopy evidence of bacteria at the lower size limit of life: Berkeley Lab research provides comprehensive description of ultra-small bacteria February 28th, 2015

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Imaging

Renishaw and Bruker team up for a workshop on TERS and co-localised AFM Raman February 26th, 2015

Real-time observation of bond formation by using femtosecond X-ray liquidography February 26th, 2015

Bruker-Sponsored Sixth AFM BioMed Conference Highlights Increasing Impact of AFM in Biological Applications February 26th, 2015

Dendrite eraser: New electrolyte rids batteries of short-circuiting fibers: Solution enables a battery with both high efficiency & current density February 24th, 2015

Nanomedicine

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Cutting-edge technology optimizes cancer therapy with nanomedicine drug combinations: UCLA bioengineers develop platform that offers personalized approach to treatment February 24th, 2015

Optical nanoantennas set the stage for a NEMS lab-on-a-chip revolution February 24th, 2015

Discoveries

First detailed microscopy evidence of bacteria at the lower size limit of life: Berkeley Lab research provides comprehensive description of ultra-small bacteria February 28th, 2015

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Announcements

Scientific breakthrough in rechargeable batteries: Researchers from Singapore and Québec Team Up to Develop Next-Generation Materials to Power Electronic Devices and Electric Vehicles February 28th, 2015

First detailed microscopy evidence of bacteria at the lower size limit of life: Berkeley Lab research provides comprehensive description of ultra-small bacteria February 28th, 2015

Leti to Offer Updates on Silicon Photonics Successes at OFC in LA February 27th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE