Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Multifunctional Nanoparticles Image, Target, and Treat Tumors

Abstract:
Encapsulating magnetic iron oxide nanoparticles within a silica shell has yielded a new multifunctional nanoparticle that has the potential to image, target, and treat tumors with water-insoluble anticancer drugs. A report of this work appears in the journal ACS Nano.

Multifunctional Nanoparticles Image, Target, and Treat Tumors

Bethesda , MD | Posted on May 21st, 2008


Back
Nanotech News


May 2008

Multifunctional Nanoparticles Image, Target, and Treat Tumors

Encapsulating magnetic iron oxide nanoparticles within a silica shell has yielded a new multifunctional nanoparticle that has the potential to image, target, and treat tumors with water-insoluble anticancer drugs. A report of this work appears in the journal ACS Nano.

Jeffery Zink, Ph.D., led a research team at the University of California, Los Angeles, that created the new nanoparticles, which contain an iron oxide nanoparticle core and a porous silica shell. The investigators coated the resulting nanoparticles with folic acid, a tumor targeting agent, and a fluorescent dye to enable optical imaging. Soaking the nanoparticles in a solvent containing either paclitaxel or camptothecin, both of which are poorly soluble in water and difficult to deliver to tumors as a result, resulted in significant drug loading through the pores in the silica shell. Tests showed that the drug-loaded nanoparticles were stable for at least 2 months.

Experiments with pancreatic cancer cells demonstrated that the targeted nanoparticles were taken up rapidly by cancer cells, whereas untargeted control nanoparticles were not. The researchers were able to quantify nanoparticle uptake using both MRI and optical spectroscopy thanks to the iron oxide nanoparticle core and fluorescent dyes, respectively. The targeted nanoparticles were also more toxic to the tumor cells than were untargeted nanoparticles.

This work, which was supported in part by the NCI, is detailed in the paper "Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery." An abstract of this paper is available at the journal's Web site.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

News and information

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Hydrogen power moves a step closer: Physicists are developing methods of creating renewable fuel from water using quantum technology September 15th, 2017

Corrosion in real time: UCSB researchers get a nanoscale glimpse of crevice and pitting corrosion as it happens September 14th, 2017

Imaging

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Chemical hot spots: Scanning tunneling microscopy measurements identify active sites on catalyst surfaces September 7th, 2017

Phenom-World selects Deben to supply a tensile stage as an accessory to their range of desktop SEMs August 29th, 2017

What the world's tiniest 'monster truck' reveals August 24th, 2017

Nanomedicine

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Arrowhead Hosts Investor & Analyst R&D Day to Introduce TRiM(TM) Platform and Lead RNAi-based Drug Candidates September 14th, 2017

Graphene based terahertz absorbers: Printable graphene inks enable ultrafast lasers in the terahertz range September 13th, 2017

Applications for the nanomedTAB are open until September 18th, 2017 September 13th, 2017

Discoveries

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Hydrogen power moves a step closer: Physicists are developing methods of creating renewable fuel from water using quantum technology September 15th, 2017

New insights into nanocrystal growth in liquid: Understanding process that creates complex crystals important for energy applications September 14th, 2017

Announcements

New quantum phenomena in graphene superlattices September 18th, 2017

Do titanium dioxide particles from orthopedic implants disrupt bone repair? September 16th, 2017

Hydrogen power moves a step closer: Physicists are developing methods of creating renewable fuel from water using quantum technology September 15th, 2017

Corrosion in real time: UCSB researchers get a nanoscale glimpse of crevice and pitting corrosion as it happens September 14th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project