Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Novel Protein Nanoparticles ‘Shape’ the Future of Disease

Abstract:
Researchers at the University of North Carolina-Chapel Hill (UNC) have granted an exclusive license to Liquidia Technologies for a protein particle fabrication method that could greatly expand the reach of protein therapeutics. Proteins are large organic molecules that perform highly specific and complex functions in the body, making them an ideal instrument to diagnose and cure disease. However, protein solubility, distribution, stability, and aggregation have hampered the development of this therapeutic class.

Novel Protein Nanoparticles ‘Shape’ the Future of Disease

Research Triangle Park, NC | Posted on May 14th, 2008

Using a nano-fabrication process known as PRINT® (Particle Replication in Non-Wetting Templates), the researchers formed protein particles of pure insulin and albumin, as well as albumin particles containing therapeutics such as siRNA and paclitaxel. These particles are designed with a predetermined size and shape profile that may optimize protein stability, solubility, and concentration, while minimizing inter-particle forces that cause aggregation.

"We expect this discovery to dramatically expand the capability and efficacy of existing protein therapeutics," said Joseph DeSimone, Liquidia founder and professor of chemistry and chemical engineering at UNC. "Design of protein particles in such a way that affords control over size and shape, and preserves protein biofunctionality, has never before been accomplished."

Unlike previous techniques, which have produced "polydisperse" particle mixtures with sizes ranging from hundreds of nanometers to tens of microns, the PRINT process forms particles of uniform size and shape. Liquidia Technologies has obtained a worldwide license to all rights for the PRINT platform and is working with partners to design protein particle therapeutics for effective delivery to the lung and other targets.

"This technology has the unique opportunity to overcome the challenges associated with protein therapeutics and contribute to the development of highly specific therapeutics for a wide range of diseases," says Liquidia CEO, Neal Fowler. "Having recently led a company that specializes in developing and commercializing biologics, I have a great appreciation and excitement for the new biotherapeutic opportunities that the PRINT platform may enable."

DeSimone and Jennifer Kelly, a graduate student in DeSimone's lab, led the research effort at UNC. Their work was published in the April 23 issue of the Journal of the American Chemical Society.

####

About Liquidia Technologies
Liquidia Technologies Inc. is a privately-held nanotechnology company that designs, develops, and manufactures precisely engineered particles and films for a wide variety of life and materials science applications. Within life sciences, Liquidia is focused on the development of Engineered Drug Therapies™ for nucleic acid delivery, and highly targeted therapeutics for the treatment of cancer and other diseases. The company was founded in 2004 on the discoveries of Professor Joseph DeSimone and colleagues at the University of North Carolina, Chapel Hill and is located in Research Triangle Park, North Carolina.

For more information, please click here

Contacts:


Liquidia Technologies
Elle Pishny
919-328-4361

Copyright © Business Wire 2008

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Nanomedicine

Northwestern scientists develop first liquid nanolaser: Technology could lead to new way of doing 'lab on a chip' medical diagnostics April 25th, 2015

Nanotech-enabled moisturizer speeds healing of diabetic skin wounds: Spherical nucleic acids silence gene that interferes with wound healing April 24th, 2015

Fast and accurate 3-D imaging technique to track optically trapped particles April 24th, 2015

A silver lining: UCSB researchers cradle silver nanoclusters inside synthetic DNA to create a programmed, tunable fluorescent array April 23rd, 2015

Announcements

Feynman Prize Winners Announced! April 26th, 2015

New ASTM Standards Will Help Educate Present and Future Nanotechnology Workforces April 26th, 2015

Heat makes electrons’ spin in magnetic superconductors April 26th, 2015

QD Vision Wins 2015 Bronze Edison Award for Color IQ™ Quantum Dot Technology April 26th, 2015

Patents/IP/Tech Transfer/Licensing

Long Island Capital Alliance Announces Participants for Brookhaven National Laboratory Technology Transfer Capital Forum on May 8: Keynote Speaker Dr. Doon Gibbs, Director of Brookhaven National Laboratory April 16th, 2015

MIT sensor detects spoiled meat: Tiny device could be incorporated into 'smart packaging' to improve food safety April 15th, 2015

Heat-Converting Material Patents Licensed April 8th, 2015

From tobacco to cyberwood March 31st, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project