Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > New Nanoparticles for Targeting Tumors

Abstract:
As a wide variety of nanoparticles continue to demonstrate their ability to improve the delivery of imaging agents and drugs to tumors, nanoparticle researchers have turned their attention to the challenge of systematically determining how a given nanoparticle's physical and chemical characteristics affect its ability to target tumors. Such data could provide drug developers with guidelines to help them select the most effective type of nanoparticle for a given therapeutic or imaging application.

New Nanoparticles for Targeting Tumors

Bethesda , MD | Posted on March 27th, 2008

In a paper published in the PNAS, a team of investigators at the MIT-Harvard Center for Cancer Nanotechnology Excellence, led by Omid Farokhzad, Ph.D., at the Harvard Medical School, and Robert Langer, Ph.D., at MIT, describe one such approach to systematizing nanoparticle development. In their research, the investigators created used two self-assembling polymer families to create series of tumor-targeted nanoparticles that varied slightly from one another in terms of their physical characteristics and their biopharmaceutical properties.

By changing the exact composition of each of the two polymers, as well as the ratio of the two polymers, the investigators found that they could fine-tune both the size and drug-releasing properties of the nanoparticles, which were targeted to the prostate-specific membrane antigen found on the surface of prostate cancer cells. The researchers also were able to vary the amount of targeting agent on the nanoparticle surface, as well as the "stealth" characteristics of the nanoparticle, that is, the ability to evade the immune system. By studying the effect of each change on nanoparticle uptake by prostate cancer cells growing in tissue culture, the investigators were able to identify the specific formulation that optimized tumor uptake in vivo.

Investigators at the University of California, Berkeley, and the University of California, San Francisco, achieved similar results with a different class of polymer nanoparticles known as dendrimers. Jean Fréchet, Ph.D., at UC-Berkeley, and Francis Szoka, at UCSF and a member of the Carolina Center of Cancer Nanotechnology Excellence, led the team of collaborators that created libraries of dendrimers containing a variety of functional groups on their surfaces. These functional groups enable the investigators to attach both PEG and any number of targeting, imaging, and therapeutic agents to the dendrimer surface in a systematic manner.

Experiments using radiolabeled dendrimers demonstrated that these nanoparticle were able to circulate in blood for long periods of time. Subsequent experiments using a dendrimer linked to the antitumor agent doxorubicin showed that drug-loaded carrier accumulated in tumors but far less in healthy tissue compared with liposomal doxorubicin, the first nanoparticle-based drug approved to treat cancer.

The work from Drs. Farokhzad and Langer, which was supported in part by the NCI's Alliance for Nanotechnology in Cancer, is detailed in the paper "Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers." An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract - “Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers.”

View abstract - “PEGylated dendrimers with core functionality for biological applications.”

Related News Press

News and information

Cool Calculations for Cold Atoms: New theory of universal three-body encounters September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Nanomedicine

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Nano-forests to reveal secrets of cells September 2nd, 2014

Nanoscale assembly line August 29th, 2014

Discoveries

New synthesis method may shape future of nanostructures, clean energy: Findings advance efficient solar spliting of water into hydrogen fuel September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Announcements

New synthesis method may shape future of nanostructures, clean energy: Findings advance efficient solar spliting of water into hydrogen fuel September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE