Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Nanotechnology Applied to Clinical Biomarker Medicine, L. Liotta

Lance Liotta
Professor
George Mason University
Lance Liotta
Professor
George Mason University

Abstract:
Lance Liotta, Professor at George Mason University, provides Nano World News with a preview of his upcoming presentation at NSTI Nanotech 2008, and he shares with regards developments related to the technology.

Nanotechnology Applied to Clinical Biomarker Medicine, L. Liotta

Cambridge, MA | Posted on March 23rd, 2008

There is a tremendous need to find novel biomarkers for sensitive and specific disease detection that will lead to a dramatic improvement in treatment outcome. Biomarkers are nucleic acids, small proteins, protein fragments, and metabolites indicative of a specific biological state that are associated with the risk of the contraction or presence of disease. Two major hurdles have prevented biomarker discovery from reaching clinical benefits: 1) biomarkers exist in exceedingly low concentrations within complex mixtures of high-abundance proteins such as albumin; 2) degradation of protein biomarkers can occur immediately following the collection of blood or body fluid as a result of endogenous or exogenous proteinases. We have introduced a charged based affinity bait molecule into N-isopropylacrylamide to produce a particle that will perform three independent functions within minutes, in one step, in solution: (a) molecular size sieving, (b) affinity capture of all solution-phase target molecules, and (c) complete protection of harvested proteins from enzymatic degradation. The captured analytes can be completely eluted from particles and are totally compatible with mass spectrometry analysis and immunoassays.

Development of Technology

This technology is being tuned to harvest and concentrate specific protein molecules out of biological fluids like blood, urine, etc. Interesting targets are known disease biomarkers like platelet derived growth factor (PDGF) or other analytes like human growth hormone (hGH) that are too rare or labile to be detected with regular clinics technology, or whose handling is currently too expensive.

Moreover, new kinds of baits are being explored, like classes of reactive dyes used in the past for affinity chromatography, in order to obtain a general affinity bait for proteins that is independent from protein charge.

The ability of hydrogel nanoparticles technology to perform a) molecular sieving, b) analytes concentration and c) protection from degradation in one step, very rapidly, and in solution is being extended to other realms beyond proteomics. Beads loaded with β-cyclodextrin are being obtained to exploit the known affinity of cyclodextrins for small metabolites to extend the use of particles to the field of metabolomics. Particles carrying boronic acid moieties are being designed and synthesized in order selectively target polysaccharides and glycopeptides in body fluids.

Dr. Liotta acknowledges the work of Dr. Alessandra Luchini, who was the author of the first publication on smart hydrohel particles: biomarker harvesting.

####

About NSTI
The Nano Science and Technology Institute (NSTI) is chartered with the promotion and integration of nano and other advanced technologies through education, technology and business development. NSTI accomplishes this mission through its offerings of continuing education programs, scientific and business publishing and community outreach. NSTI produces the annual Nanotech conference and trade show, the most comprehensive international nanotechnology convention in the world. NSTI also produces the semi-annual Nanotech Venture, Nanotech Industrial Impact Workshop, Nano Impact Summit and the Nanotech Course Series in the US and Europe. NSTI was founded in 1997 as a result of the merger between various scientific societies, and is headquartered in Cambridge, Massachusetts with additional offices in California and Switzerland.

For more information, please click here

Contacts:
Sarah Wenning
696 San Ramon Valley Blvd., Ste. 423
Danville, CA 94526
Ph: (925) 901-4959
Fax: (925) 886-8461

Copyright © NSTI

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Composite Pipe Long Term Testing Facility February 10th, 2016

Scientists take nanoparticle snapshots February 10th, 2016

Chemical cages: New technique advances synthetic biology February 10th, 2016

New thin film transistor may lead to flexible devices: Researchers engineer an electronics first, opening door to flexible electronics February 10th, 2016

Nanomedicine

Nanoparticle therapy that uses LDL and fish oil kills liver cancer cells February 9th, 2016

Leading bugs to the death chamber: A kinder face of cholesterol February 8th, 2016

UTHealth research looks at nanotechnology to help prevent preterm birth February 7th, 2016

Scientists take key step toward custom-made nanoscale chemical factories: Berkeley Lab researchers part of team that creates new function in tiny protein shell structures February 6th, 2016

Announcements

Composite Pipe Long Term Testing Facility February 10th, 2016

Scientists take nanoparticle snapshots February 10th, 2016

Chemical cages: New technique advances synthetic biology February 10th, 2016

New thin film transistor may lead to flexible devices: Researchers engineer an electronics first, opening door to flexible electronics February 10th, 2016

Events/Classes

Nanotech Security to Present at the Optical Document Security Conference February 11, 2016 February 4th, 2016

New research uses nanotechnology to prevent preterm birth: March of Dimes honors abstract on prematurity at SMFM Annual Meeting February 2nd, 2016

NBC LEARN DEBUTS SIX-PART VIDEO SERIES, “NANOTECHNOLOGY: SUPER SMALL SCIENCE” Produced by NBC Learn in partnership with the National Science Foundation, and narrated by NBC News/MSNBC’s Kate Snow, series highlights leading research in nanotechnology January 25th, 2016

Leti to Host Workshop on New Photonics Applications During SPIE Photonics West: Researchers also Will Present Four Invited Papers At Feb. 13-18 Conference, 14 Papers, Overall January 25th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic