Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Bruker Daltonics Announces FlashFormula™ NALDI-TOF Solution

Abstract:
Nanotechnology-Enabled Targets for High-Throughput Molecular Formula Determination of Small Molecules without LC-separations using NALDI-TOF-MS

Bruker Daltonics Announces FlashFormula™ NALDI-TOF Solution

NEW ORLEANS, LA | Posted on March 11th, 2008

At Pittcon 2008, Bruker Daltonics announced the novel FlashFormula™ solution for the identification and molecular sum formula determination of small molecules for use with Bruker's FLEX™-series of laser desorption ionization (LDI) time-of-flight (TOF) mass spectrometers and processing software. The method uses the robust and sensitive nanotechnology-based NALDI targets developed for direct deposit, matrix-free LDI analysis.

NALDI targets have significant throughput and ease-of-use benefits for the analysis of a wide variety of small molecules such as drug compounds, small peptides, natural products, pesticides, low mass polymers, as well as polymer additives such as plasticizers and stabilizers. Many of these molecules were previously difficult to analyze with MALDI-TOF mass spectrometers and are typically analyzed with LC-MS (liquid chromatography - mass spectrometry), which is time-consuming, less robust and requires more operator training.

Bruker's SmartFormula™ method uses a True Isotopic Pattern (TIP) fitting algorithm plus accurate mass information for obtaining molecular sum formulae with ESI-TOF and FTMS instruments. Now the same approach is enabled for rapid compound identification and sum formula determination from NALDI-TOF results. For small molecules, the accurate isotopic pattern measured with the FLEX instruments, together with LDI-TOF mass accuracy in the low-ppm range using internal or near-neighbour calibration, often enables unique formula determination. Compounds containing elements such as halogens, sulphur, phosphorus or organometallic complexes, also typically give dependable isotopic patterns and formula results.

FlashFormula™ is a name that reflects the speed and simplicity of molecular formula finding with a NALDI-TOF system. The dedicated 96-position NALDI targets have a form-factor compatible with all FLEX -series instruments. Small molecules are captured from liquid droplets onto the targets, an optional washing step removes salts and protein contaminants, and measurement takes a few seconds per sample, followed by automated data interpretation. Detection limits are compound dependant, but many molecules give impressive results at a low picogram level on target. A linear quantitation range of more than 3 orders of magnitude is possible with the addition of known levels of an internal calibrant.

Users of FlashFormula are expected to include the many labs where the majority of research focuses on conventional MALDI-TOF analysis of proteins, peptides and polymers, but where there is additional need for small molecule analysis. By enabling such analyses on the same analytical platform, instrumentation purchasing and training needs are greatly simplified.

Catherine Stacey, Ph.D., the Bruker Daltonics U.S. Director of Applications, commented: "The unique capabilities for fast and easy identification and formula determination without lengthy LC separations offered by FlashFormula, using NALDI targets in combination with our industry-leading TOF and TOF/TOF mass spectrometers, open up a breadth of new research and applied market opportunities for small molecules analysis. We are very pleased to offer this enabling nanotechnology-based solution to address new application areas."

####

About Nanosys, Inc.
Nanosys, Inc. is a leader in the development of nanotechnology enabled products utilizing high performance inorganic nanostructures. Nanosys has built one of the broadest technology platforms in the industry with approximately 500 patents and patent applications covering fundamental areas of nanotechnology. Based in Palo Alto, California and privately held, Nanosys collaborates with industry leaders to develop revolutionary high-value, high-performance products for computing, optoelectronics, communications, renewable energy, defense and the life sciences.

The NALDI targets are developed and manufactured by Nanosys Inc, and are exclusively distributed by Bruker Daltonics under a collaboration agreement.

For more information, please click here

Contacts:
Peter Garcia
Nanosys Chief Financial Officer
+1 (650) 331-2154


Michael Willett
Bruker Daltonics
Public Relations Officer
+1 (978) 663-3660, ext. 1411


Contact Information:
Bruker
Michael Willett
Tel: +1 (978) 663-3660

Copyright © Nanosys, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Chemistry

Production of Toxic Ion Nanosorbents with High Sorption Capacity in Iran August 17th, 2014

Scientists fold RNA origami from a single strand: RNA origami is a new method for organizing molecules on the nanoscale. Using just a single strand of RNA, this technique can produce many complicated shapes. August 14th, 2014

Could hemp nanosheets topple graphene for making the ideal supercapacitor? August 12th, 2014

Iranians Find Novel Method for Processing Highly Pure Ceramic Nanoparticles August 12th, 2014

Announcements

A new, tunable device for spintronics: An international team of scientists including physicist Jairo Sinova from the University of Mainz realises a tunable spin-charge converter made of GaAs August 29th, 2014

Nanoscale assembly line August 29th, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

New Vice President Takes Helm at CNSE CMOST: Catherine Gilbert To Lead CNSE Children’s Museum of Science and Technology Through Expansion And Relocation August 29th, 2014

Tools

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

Ultra-Low Frequency Vibration Isolation Stabilizes Scanning Tunneling Microscopy at UCLA’s Nano-Research Group August 28th, 2014

Measure Both Elastic and Viscous Properties with AFM Using Asylum Research’s Exclusive AM-FM Viscoelastic Mapping Mode August 28th, 2014

Malvern specialists to deliver inaugural short course on polymer characterization at Interplas 2014 August 27th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE