Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > Bruker Daltonics Announces FlashFormula™ NALDI-TOF Solution

Abstract:
Nanotechnology-Enabled Targets for High-Throughput Molecular Formula Determination of Small Molecules without LC-separations using NALDI-TOF-MS

Bruker Daltonics Announces FlashFormula™ NALDI-TOF Solution

NEW ORLEANS, LA | Posted on March 11th, 2008

At Pittcon 2008, Bruker Daltonics announced the novel FlashFormula™ solution for the identification and molecular sum formula determination of small molecules for use with Bruker's FLEX™-series of laser desorption ionization (LDI) time-of-flight (TOF) mass spectrometers and processing software. The method uses the robust and sensitive nanotechnology-based NALDI targets developed for direct deposit, matrix-free LDI analysis.

NALDI targets have significant throughput and ease-of-use benefits for the analysis of a wide variety of small molecules such as drug compounds, small peptides, natural products, pesticides, low mass polymers, as well as polymer additives such as plasticizers and stabilizers. Many of these molecules were previously difficult to analyze with MALDI-TOF mass spectrometers and are typically analyzed with LC-MS (liquid chromatography - mass spectrometry), which is time-consuming, less robust and requires more operator training.

Bruker's SmartFormula™ method uses a True Isotopic Pattern (TIP) fitting algorithm plus accurate mass information for obtaining molecular sum formulae with ESI-TOF and FTMS instruments. Now the same approach is enabled for rapid compound identification and sum formula determination from NALDI-TOF results. For small molecules, the accurate isotopic pattern measured with the FLEX instruments, together with LDI-TOF mass accuracy in the low-ppm range using internal or near-neighbour calibration, often enables unique formula determination. Compounds containing elements such as halogens, sulphur, phosphorus or organometallic complexes, also typically give dependable isotopic patterns and formula results.

FlashFormula™ is a name that reflects the speed and simplicity of molecular formula finding with a NALDI-TOF system. The dedicated 96-position NALDI targets have a form-factor compatible with all FLEX -series instruments. Small molecules are captured from liquid droplets onto the targets, an optional washing step removes salts and protein contaminants, and measurement takes a few seconds per sample, followed by automated data interpretation. Detection limits are compound dependant, but many molecules give impressive results at a low picogram level on target. A linear quantitation range of more than 3 orders of magnitude is possible with the addition of known levels of an internal calibrant.

Users of FlashFormula are expected to include the many labs where the majority of research focuses on conventional MALDI-TOF analysis of proteins, peptides and polymers, but where there is additional need for small molecule analysis. By enabling such analyses on the same analytical platform, instrumentation purchasing and training needs are greatly simplified.

Catherine Stacey, Ph.D., the Bruker Daltonics U.S. Director of Applications, commented: "The unique capabilities for fast and easy identification and formula determination without lengthy LC separations offered by FlashFormula, using NALDI targets in combination with our industry-leading TOF and TOF/TOF mass spectrometers, open up a breadth of new research and applied market opportunities for small molecules analysis. We are very pleased to offer this enabling nanotechnology-based solution to address new application areas."

####

About Nanosys, Inc.
Nanosys, Inc. is a leader in the development of nanotechnology enabled products utilizing high performance inorganic nanostructures. Nanosys has built one of the broadest technology platforms in the industry with approximately 500 patents and patent applications covering fundamental areas of nanotechnology. Based in Palo Alto, California and privately held, Nanosys collaborates with industry leaders to develop revolutionary high-value, high-performance products for computing, optoelectronics, communications, renewable energy, defense and the life sciences.

The NALDI targets are developed and manufactured by Nanosys Inc, and are exclusively distributed by Bruker Daltonics under a collaboration agreement.

For more information, please click here

Contacts:
Peter Garcia
Nanosys Chief Financial Officer
+1 (650) 331-2154


Michael Willett
Bruker Daltonics
Public Relations Officer
+1 (978) 663-3660, ext. 1411


Contact Information:
Bruker
Michael Willett
Tel: +1 (978) 663-3660

Copyright © Nanosys, Inc.

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Light and matter merge in quantum coupling: Rice University physicists probe photon-electron interactions in vacuum cavity experiments August 24th, 2016

New microchip demonstrates efficiency and scalable design: Increased power and slashed energy consumption for data centers August 24th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

University of Puerto Rico and NASA back in the news – XEI reports August 23rd, 2016

Chemistry

A new way to display the 3-D structure of molecules: Metal-organic frameworks provide a new platform for solving the structure of hard-to-study samples August 21st, 2016

Researchers watch catalysts at work August 19th, 2016

Pokhara, the second largest city of Nepal, to host its first ever International Meeting on Material Sciences and Engineering August 15th, 2016

'Liquid fingerprinting' technique instantly identifies unknown liquids: Ability to instantly identify unknown liquids in the field could aid first responders, improve plant safety August 4th, 2016

Announcements

Light and matter merge in quantum coupling: Rice University physicists probe photon-electron interactions in vacuum cavity experiments August 24th, 2016

New microchip demonstrates efficiency and scalable design: Increased power and slashed energy consumption for data centers August 24th, 2016

Tunneling nanotubes between neurons enable the spread of Parkinson's disease via lysosomes August 24th, 2016

University of Puerto Rico and NASA back in the news – XEI reports August 23rd, 2016

Tools

University of Puerto Rico and NASA back in the news – XEI reports August 23rd, 2016

Spider silk: Mother Nature's bio-superlens August 22nd, 2016

Tracing barnacle's footprint August 19th, 2016

XEI Scientific celebrates its Silver Anniversary August 16th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic