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The VenaFlux(TM) Platform Accurately Mimics a Human Capillary
Cellix Ltd., an international provider of microfluidic systems in the emerging field of nano-lifesciences, announced today its worldwide launch of its VenaFlux(TM) Platform. The VenaFlux(TM), the first semi-automated, high throughput microfluidic cell- based assay system, measures cell adhesion to antibody-coated or endothelial- cell cultured microchannels, producing IC50 curves under shear stress conditions mimicking physiological flow. The system thereby offers scientists an important and unique tool for drug discovery. The VenaFlux(TM) is simple to use, reduces costly layers of animal model studies, and delivers specific, accurate, and reproducible results.
Using the VenaFlux(TM), scientists can rapidly obtain quantitative analyses and results for potential drug candidates in therapeutic areas including cardiovascular, respiratory, immunologic, autoimmune and oncologic disease states. Relatively rapid analyses reduces drug development costs by accelerating false lead elimination and increasing productivity in pharmaceutical and biotechnology research and development laboratories.
"Understanding how cells behave in human capillaries is an expanding area in global research and development for discovering new patient therapies," said Vivienne Williams, CEO of Cellix Ltd. "Our VenaFlux(TM) accurately replicates cell behavior in human capillaries, an in vitro modeling system that has previously been difficult to achieve.
Cellix's technology provides researchers with a single platform for executing dynamic studies to analyze the effects of drugs on cell adhesion, proliferation and transmigration under well-defined shear stress protocols that replicate physiological conditions. "To date, pharmaceutical companies including AstraZeneca and Amgen, as well as research institutions such as the US National Institutes of Health have adopted Cellix's technology to characterize drug effects," commented Ms. Williams.
About the VenaFlux Platform
The VenaFlux(TM) Platform consists of Cellix's patented Mirus(TM) Nanopump with VenaFluxAssay(TM) software, Vena8(TM) Biochips and DucoCell(TM) analysis software; Carl Zeiss Axiovert(TM) 40 CFL microscope, motorized stage with Z- focus, microscope cage incubator, automated dispenser arm, digital camera for image acquisition and PC. The VenaFlux(TM) Platform can run 8 microcapillaries in 15 minutes, thereby achieving 32 assays in one hour or approximately 1,000 assays per week. The VenaFlux(TM) Platform provides an important new in vitro alternative to expensive animal models while simultaneously cutting down costs on reagents and manpower.
About Cellix Ltd.
Cellix Ltd. is a privately held instrumentation and cell-based assay company developing technologies that accurately mimic cellular behavior in vivo for cell-based screening in drug discovery. The Company is headquartered in Dublin, Ireland, and maintains offices in New York City.
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