Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Artificial Viral Shells Could Be Useful Nano-Containers

Abstract:
Inspired by the shell that encloses a virus' genetic material, researchers at the Technion-Israel Institute of Technology and The Scripps Research Institute are designing an artificial viral shell as a valuable nano-container for pinpoint drug delivery, molecular computing components, and a host of other applications.

Artificial Viral Shells Could Be Useful Nano-Containers

New York, NY | Posted on January 2nd, 2008

Researchers at the Technion-Israel Institute of Technology and The Scripps Research Institute in California are designing an artificial viral shell as a valuable nano-container for pinpoint drug delivery, molecular computing components, and a host of other applications.

Technion chemist Ehud Keinan and colleagues were inspired by the construction of natural viral capsids, which enclose a virus's genetic material within a sphere knitted together from identical protein building blocks.

Like a soccer ball - or its nano-equivalent the carbon buckyball - the viral capsid combines these protein units into a sphere with a large surface to volume ratio—that is, a tiny sphere with a relatively roomy interior. These design features, combined with the fact that viral capsids assemble themselves with little prompting, make the capsid an excellent model for artificial nano-capsules, the researchers report in the Proceedings of National Academy of Sciences this week.

Artificial capsids could act as cargo containers that deliver drugs to targeted areas of the body, vessels that shuttle replacement genes to their new homes in the genome as part of gene therapy, or tiny enclosed laboratories for doing chemical reactions or building molecular computer parts.

Keinan said the size of artificial capsids "is very important. It will determine which molecules we'll be able to pack inside the container. Small containers will allow for drug delivery, big ones for delivering proteins and very big for the delivery of genes."

The researchers decided to pick apart the construction of viral capsids to determine exactly how their identical parts come together. They built a handful of pentagonal tiles with magnetic edges that mimic the chemically-bonding edges of natural capsid proteins. In some of their first experiments, they simply shook the magnetic tiles together in a plastic jar and watched the pieces snap together to form a sphere.

"Although intellectually we knew that this type of self-organization occurs spontaneously, watching it happen from random shaking on the macroscopic scale was inspirational," Keinan and colleagues write in their paper.

The researchers then turned to computer simulations of capsid construction, working with the dish-shaped chemical compound called corannulene. Also called the buckybowl, corannulene has a five-sided symmetry and rigid curve that makes it a potentially good building block for an artificial capsid.
In the simulations, Keinan and colleagues experimented with different chemical "sticky edges" to the corannulene building blocks to determine the conditions under which the corannulene units would self-assemble into a ball. They created a half-sphere in the simulation, and expect to have a full sphere soon.

By applying different kinds of chemical bonds at the sticky edges—from weak hydrogen bonds to metal bonds to strong disulfide bonds—the researchers believe they can alter the strength of the capsid and affect the conditions under which it assembles or disassembles, Keinan said.

Although the researchers have yet to build an artificial capsid in the lab, "the present study gives us confidence that we can design molecules based on these principles that can assemble into chemical capsids," they write.

####

About American Technion Society
The Technion-Israel Institute of Technology is Israel's leading science and technology university. Home to the country’s winners of the Nobel Prize in science, it commands a worldwide reputation for its pioneering work in nanotechnology, computer science, biotechnology, water-resource management, materials engineering, aerospace and medicine. The majority of the founders and managers of Israel's high-tech companies are alumni. Based in New York City, the American Technion Society (ATS) is the leading American organization supporting higher education in Israel, with 21 offices around the country.

For more information, please click here

Contacts:
Technion-Israel Institute of Technology 55 East 59th St.
New York, NY 10022
United States
Fax 212-753-2925
Kevin Hattori

212.407.6319

Copyright © American Technion Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Nanomedicine

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

These microscopic fish are 3-D-printed to do more than swim: Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities August 26th, 2015

Discoveries

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

CWRU researchers efficiently charge a lithium-ion battery with solar cell: Coupling with perovskite solar cell holds potential for cleaner cars and more August 27th, 2015

Announcements

Iranian Scientists Use Artemisia Annua Plant to Produce Breast Cancer Drugs August 29th, 2015

Small but heading for the big time: Nanobiotix half year results for the six months ended 30 June 2015, in line with expectations: Major clinical achievements and corporate developments August 28th, 2015

A new technique to make drugs more soluble August 28th, 2015

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Research partnerships

Nanocatalysts improve processes for the petrochemical industry August 28th, 2015

Announcing Oxford Instruments and School of Physics signing a Memorandum of Understanding August 26th, 2015

Researchers combine disciplines, computational programs to determine atomic structure August 26th, 2015

Developing Component Scale Composites Using Nanocarbons August 26th, 2015

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic