Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Artificial Viral Shells Could Be Useful Nano-Containers

Abstract:
Inspired by the shell that encloses a virus' genetic material, researchers at the Technion-Israel Institute of Technology and The Scripps Research Institute are designing an artificial viral shell as a valuable nano-container for pinpoint drug delivery, molecular computing components, and a host of other applications.

Artificial Viral Shells Could Be Useful Nano-Containers

New York, NY | Posted on January 2nd, 2008

Researchers at the Technion-Israel Institute of Technology and The Scripps Research Institute in California are designing an artificial viral shell as a valuable nano-container for pinpoint drug delivery, molecular computing components, and a host of other applications.

Technion chemist Ehud Keinan and colleagues were inspired by the construction of natural viral capsids, which enclose a virus's genetic material within a sphere knitted together from identical protein building blocks.

Like a soccer ball - or its nano-equivalent the carbon buckyball - the viral capsid combines these protein units into a sphere with a large surface to volume ratio—that is, a tiny sphere with a relatively roomy interior. These design features, combined with the fact that viral capsids assemble themselves with little prompting, make the capsid an excellent model for artificial nano-capsules, the researchers report in the Proceedings of National Academy of Sciences this week.

Artificial capsids could act as cargo containers that deliver drugs to targeted areas of the body, vessels that shuttle replacement genes to their new homes in the genome as part of gene therapy, or tiny enclosed laboratories for doing chemical reactions or building molecular computer parts.

Keinan said the size of artificial capsids "is very important. It will determine which molecules we'll be able to pack inside the container. Small containers will allow for drug delivery, big ones for delivering proteins and very big for the delivery of genes."

The researchers decided to pick apart the construction of viral capsids to determine exactly how their identical parts come together. They built a handful of pentagonal tiles with magnetic edges that mimic the chemically-bonding edges of natural capsid proteins. In some of their first experiments, they simply shook the magnetic tiles together in a plastic jar and watched the pieces snap together to form a sphere.

"Although intellectually we knew that this type of self-organization occurs spontaneously, watching it happen from random shaking on the macroscopic scale was inspirational," Keinan and colleagues write in their paper.

The researchers then turned to computer simulations of capsid construction, working with the dish-shaped chemical compound called corannulene. Also called the buckybowl, corannulene has a five-sided symmetry and rigid curve that makes it a potentially good building block for an artificial capsid.
In the simulations, Keinan and colleagues experimented with different chemical "sticky edges" to the corannulene building blocks to determine the conditions under which the corannulene units would self-assemble into a ball. They created a half-sphere in the simulation, and expect to have a full sphere soon.

By applying different kinds of chemical bonds at the sticky edges—from weak hydrogen bonds to metal bonds to strong disulfide bonds—the researchers believe they can alter the strength of the capsid and affect the conditions under which it assembles or disassembles, Keinan said.

Although the researchers have yet to build an artificial capsid in the lab, "the present study gives us confidence that we can design molecules based on these principles that can assemble into chemical capsids," they write.

####

About American Technion Society
The Technion-Israel Institute of Technology is Israel's leading science and technology university. Home to the country’s winners of the Nobel Prize in science, it commands a worldwide reputation for its pioneering work in nanotechnology, computer science, biotechnology, water-resource management, materials engineering, aerospace and medicine. The majority of the founders and managers of Israel's high-tech companies are alumni. Based in New York City, the American Technion Society (ATS) is the leading American organization supporting higher education in Israel, with 21 offices around the country.

For more information, please click here

Contacts:
Technion-Israel Institute of Technology 55 East 59th St.
New York, NY 10022
United States
Fax 212-753-2925
Kevin Hattori

212.407.6319

Copyright © American Technion Society

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

News and information

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Nanomedicine

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Supercrystals with new architecture can enhance drug synthesis May 24th, 2016

Nanoscale Trojan horses treat inflammation May 24th, 2016

Tiny packages may pack powerful treatment for brain tumors: Nanocarrier provides efficient delivery of chemotherapeutic drug May 23rd, 2016

Discoveries

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

PETA science group publishes a review on pulmonary effects of nanomaterials: Archives of Toxicology publishes a review of scientific studies on fibrotic potential of nanomaterials May 26th, 2016

Harnessing solar and wind energy in one device could power the 'Internet of Things' May 26th, 2016

Announcements

Scientists illuminate a hidden regulator in gene transcription: New super-resolution technique visualizes important role of short-lived enzyme clusters May 27th, 2016

Doubling down on Schrödinger's cat May 27th, 2016

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

Deep Space Industries and SFL selected to provide satellites for HawkEye 360’s Pathfinder mission: The privately-funded space-based global wireless signal monitoring system will be developed by Deep Space Industries and UTIAS Space Flight Laboratory May 26th, 2016

Research partnerships

Finding a new formula for concrete: Researchers look to bones and shells as blueprints for stronger, more durable concrete May 26th, 2016

The next generation of carbon monoxide nanosensors May 26th, 2016

Revealing the nature of magnetic interactions in manganese oxide: New technique for probing local magnetic interactions confirms 'superexchange' model that explains how the material gets its long-range magnetic order May 25th, 2016

Light can 'heal' defects in new solar cell materials: Defects in some new electronic materials can be removed by making ions move under illumination May 24th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic