Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > New Drug Combination is Able to Eradicate Breast Metastases in Mice

Abstract:
A novel combination of drugs was able to completely eradicate human breast metastases growing in mice, and shows promise for the effective treatment of patients with advanced metastatic breast cancer. Dr. Sophia Ran from Southern Illinois University School of Medicine presented the results of a study using nab-paclitaxel and bevacizumab to treat lymphatic and pulmonary metastases in female SCID mice.

New Drug Combination is Able to Eradicate Breast Metastases in Mice

SAN ANTONIO, TX | Posted on December 17th, 2007

Paclitaxel is a widely used cancer chemotherapy drug, originally derived from an extract of the yew tree. It can have severe side effects, some of which are related to the fact that it will not dissolve in water and has to be dissolved in organic solvents for injection. Nab-paclitaxel is a nanoparticle form of paclitaxel that is coated with a nonreactive protein, albumin, allowing it to be dissolved in water. This has reduced the side effects of the treatment, and also makes it more effective.

Bevacizumab is a monoclonal antibody against vascular endothelial growth factor A (VEGF-A), a protein that is involved in building new blood vessels. Tumors require new networks of blood vessels in order to grow.

The idea for this research came from the observation that, nf cells that survive treatment with chemotherapy, the stress of the treatment causes excess VEGF-A to be produced. The VEGF-A protects the cells against future chemotherapy, and also generates new blood vessels. Both mechanisms may contribute to tumor recurrence and metastatic spread following chemotherapy. This is the molecular basis for combining bevacizumab with nab-paclitaxel for the treatment of metastatic tumors.

For this study, human breast cancer cells were implanted into mammary fat pads (the mouse equivalent of breast tissue) of female mice. The implanted cells grew into tumors, and lymphatic and pulmonary metastases developed by the time that the drugs were administered.

The drug combination completely eradicated the original tumors, although bevacizumab alone had no effect, and nab-paclitaxel alone caused tumor regression for only 27 days, after which the tumors grew back.

The drug combination also completely eradicated metastases in the treated animals. Bevacizumab alone and nab-paclitaxel alone reduced the average number of metastases by no more than 50%.

The combination of bevacizumab and nab-paclitaxel is currently being tested in early trials of women with metastatic breast cancer.

####

For more information, please click here

Contacts:
Rich Markow, Symposia Director
7979 Wurzbach Rd., Suite U-524
San Antonio, TX 78229
USA
Phone: (210) 450-5912
Fax: (210) 450-5009
Email:

Copyright © San Antonio Breast Cancer Symposium

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizardŽ AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

Announcements

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

New nontoxic process promises larger ultrathin sheets of 2-D nanomaterials July 27th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic