Nanotechnology Now

Our NanoNews Digest Sponsors





Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > Polymer Cage Stabilizes Liposome, Improves Drug Delivery

Abstract:
Liposomes, the first type of nanoparticle to achieve clinical use, are remarkably versatile constructs, but they suffer from a general lack of stability. But researchers at the Nanomaterials for Cancer Diagnostics and Therapeutics Center for Cancer Nanotechnology Excellence at Northwestern University have developed a method for stabilizing liposomes within a polymer cage. More importantly, the polymer cage is constructed to fall apart and trigger drug release from the liposome when taken into cells.

Polymer Cage Stabilizes Liposome, Improves Drug Delivery

Bethesda , MD | Posted on December 5th, 2007

Reporting its work in the Journal of the American Chemical Society, a research team led by Thomas O'Halloran, Ph.D., and SonBinh Nguyen, Ph.D., showed that a cholesterol-poly(acrylic acid) construct could be inserted into the outer membrane of a liposome and then crosslinked with the poly(acrylic acid) chains to form what is essentially a cage surrounding the liposome. The resulting polymer-caged liposomes are stable, both in serum and during freeze-drying and rehydration. This latter observation is a promising observation for future commercial production and shelf-life concerns. In contrast, freeze-drying and rehydration destroy conventional liposomes. In one assay, the investigators found that only about 5 percent of the liposome's payload leaked out of the formulation over the course of 500 hours.

Of course, a permanently stable construct that would not release its contents would not serve well as a drug delivery vehicle, but this particular polymer cage is unstable at the pH found inside tumor cells. Indeed, when incubated at pH 4, the polymer-caged liposomes released 84 percent of their payload over 150 hours. The researchers note that their process should work with any liposome and that the polymer cage can also serve as a ready point of attachment for targeting ligands.

This work, which was supported in part by the National Cancer Institute's Alliance for Nanotechnology in Cancer, is detailed in the paper "Polymer-caged liposomes: pH-responsive delivery system with high stability." This paper was published online in advance of print publication. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

Nanomedicine

Innovative strategy to facilitate organ repair April 18th, 2014

Novel stapled peptide nanoparticle combination prevents RSV infection, study finds April 17th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

High-temperature plasmonics eyed for solar, computer innovation April 17th, 2014

Discoveries

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Thinnest feasible membrane produced April 17th, 2014

More effective kidney stone treatment, from the macroscopic to the nanoscale April 17th, 2014

Announcements

'Exotic' material is like a switch when super thin April 18th, 2014

Innovative strategy to facilitate organ repair April 18th, 2014

Oxford Instruments Asylum Research Introduces the MFP-3D InfinityTM AFM Featuring Powerful New Capabilities and Stunning High Performance April 18th, 2014

Transparent Conductive Films and Sensors Are Hot Segments in Printed Electronics: Start-ups in these fields show above-average momentum, while companies working on emissive displays such as OLED are fading, Lux Research says April 17th, 2014

NanoNews-Digest
The latest news from around the world, FREE







  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE