Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Radio Waves Fire Up Nanotubes Embedded in Tumors, Destroying Liver Cancer

Abstract:
Cancer cells treated with carbon nanotubes can be destroyed by noninvasive radio waves that heat up the nanotubes while sparing untreated tissue, a research team led by scientists at The University of Texas M.D. Anderson Cancer Center and Rice University has shown in preclinical experiments. In a paper published in the journal Cancer, the researchers demonstrated that the technique completely destroyed liver cancer tumors in rabbits. There were no side effects noted. However, some healthy liver tissue within 2 to 5 millimeters of the tumors sustained heat damage due to nanotube leakage from the tumor.

Radio Waves Fire Up Nanotubes Embedded in Tumors, Destroying Liver Cancer

Bethesda , MD | Posted on December 5th, 2007

"These are promising, even exciting, preclinical results in this liver cancer model," said lead investigator Steven Curley, M.D., of M.D. Anderson. "Our next step is to look at ways to more precisely target the nanotubes so they attach to, and are taken up by, cancer cells while avoiding normal tissue."

Curley conducted the research in collaboration with nanotechnology experts at Rice University and with Erie, Pennsylvania, entrepreneur John Kanzius of ThermMed LLC, who invented the experimental radiofrequency generator used in the experiments. Kanzius is a cancer survivor and former radio station owner whose insights into the potential of targeted radio waves inspired this line of research. At Rice, the work was begun by Nobel laureate Richard Smalley several months before his death from cancer in October 2005.

In the liver cancer experiment, a solution of single-walled carbon nanotubes was injected directly into the tumors. Four treated rabbits were then exposed to 2 minutes of radiofrequency treatment, resulting in thermal destruction of their tumors. Control group tumors that were treated only by radiofrequency exposure or only by nanotubes were undamaged. In lab experiments, two lines of liver cancer cells and one pancreatic cancer cell line were destroyed after being incubated with nanotubes and exposed to the radiofrequency field.

Curley stated that radiofrequency energy fields penetrate deeply into tissue, so it would be possible to deliver heat anywhere in the body if targeted nanotubes or other nanoparticles can be delivered to cancerous cells. Without such a target, radio waves will pass harmlessly through the body.

An invasive technique known as radiofrequency ablation is used to treat some malignant tumors, the authors note. It requires insertion of needle electrodes directly into the tumors. Incomplete tumor destruction occurs in 5 to 40 percent of cases; normal tissue is damaged, and complications arise in 10 percent of patients who suffer such damage. Radiofrequency ablation is limited to liver, kidney, breast, lung, and bone cancers.

This work is detailed in the paper "Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field." Investigators from Rice University, ThermMed LLC, and the National Center for Scientific Research in Bordeaux, France, also participated in this study. This paper was published online in advance of print publication. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:

National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related Links

View abstract

Related News Press

Nanomedicine

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Arrowhead Presents New Clinical Data Demonstrating a Sustained Host Response in Hepatitis B Patients Following RNAi Therapy — Up to 5.0 log10 reduction in HBsAg observed; data presented at HEP DART 2017 — December 6th, 2017

Discoveries

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Untangling DNA: Researchers filter the entropy out of nanopore measurements December 8th, 2017

Announcements

Sandia researchers make solid ground toward better lithium-ion battery interfaces: Reducing the traffic jam in batteries December 13th, 2017

Perking up and crimping the 'bristles' of polyelectrolyte brushes December 13th, 2017

Columbia engineers create artificial graphene in a nanofabricated semiconductor structure: Researchers are the first to observe the electronic structure of graphene in an engineered semiconductor; finding could lead to progress in advanced optoelectronics and data processing December 13th, 2017

Leti to Demo Wristband with Embedded Sensors to Diagnose Sleep Apnea: APNEAband, Which Will Be Demonstrated at CES 2018, Also Monitors Mountain Sickness, Dehydration, Dialysis Treatment Response and Epileptic Seizures December 12th, 2017

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project