Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > NIH Awards Professor $3.96 Mil Grant

Michael Jay - Ph.D.
Michael Jay - Ph.D.

Abstract:
A drug therapy to protect the U.S. population from the consequences of nuclear terrorism is being pioneered by scientists at the University of Kentucky College of Pharmacy. The National Institutes of Health (NIH) awarded Michael Jay, professor of pharmaceutical sciences in the UK College of Pharmacy, $3.96 million over the next two years to develop an orally administered treatment to be used in radiation emergencies such as after exposure to radiological dispersion devices (RDDs) or dirty bombs.

NIH Awards Professor $3.96 Mil Grant

LEXINGTON, KY | Posted on November 30th, 2007

This grant comes in response to the encouraging results from Jay's initial study in 2005 for which the NIH awarded him $1.2 million. Jay and his colleagues, Robert Yokel, professor and associate dean for research and graduate education, Patrick McNamara, professor and chair of the Department of Pharmaceutical Sciences and Russ Mumper, professor and director of the Center for Nanotechnology in Drug Delivery at the University of North Carolina, began synthesizing a series of compounds and quickly focused in on one that they will continue to study in the current product development phase.

Internal exposure to radioactive material from the detonation of dirty bombs constitutes a health hazard because of the continuous emission of radioactivity to radiosensitive tissues and subsequent development of cell death, organ dysfunction and cancer. Internalization of radioactive material may occur via inhalation, ingestion or through contamination of open wounds which can be transported through the body via the blood.

The U.S. Food and Drug Administration (FDA) has determined that a drug called DTPA (diethylenetriaminepentaacetate) is safe and effective for the treatment of internal contamination. Currently, DPTA is not absorbed very well when administered orally, thus, it must be administered intravenously. The ultimate goal of Jay's study is to develop a highly bioavailable form of DTPA that can be administered orally, can be stored in the Strategic National Stockpile, is stable and has a long shelf-life, can be distributed to the at-risk population in a short period of time, can be self-administered with little risk of toxicity, and can effectively remove radioactivity from a contaminated individual. An orally bioavailable form of DTPA offers many advantages over an injectable form, such as, greater stability, less expense in manufacturing, no need for a trained professional to administer the dose and no risk of bacterial contamination.

####

For more information, please click here

Contacts:
Ann Blackford
(859) 323-6363, x230

Copyright © University of Kentucky

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Govt.-Legislation/Regulation/Funding/Policy

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Exploring phosphorene, a promising new material April 29th, 2016

Academic/Education

JPK reports on the use of a NanoWizard AFM system at the University of Kaiserslautern to study the interaction of bacteria with microstructured surfaces April 28th, 2016

The Ottawa Hospital Research Institute uses the ZetaView from Particle Metrix to study membrane microparticles as potential biomarkers for underlying diseases April 12th, 2016

FEI Partners with Five Pharmaceutical Companies, the Medical Research Council and the University of Cambridge to form Cryo-EM Research Consortium April 5th, 2016

SUNY Poly, in Collaboration with the George Washington School of Medicine and Health Sciences and Stony Brook University, Demonstrates Pioneering Method to Visualize and Identify Engineered Nanoparticles in Tissue March 25th, 2016

Nanomedicine

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Nanoparticles hold promise as double-edged sword against genital herpes April 28th, 2016

Arrowhead Pharmaceuticals Files for Regulatory Clearance to Begin Phase 1/2 Study of ARC-521 April 28th, 2016

The Translational Research Center at the University Hospital of Erlangen in Germany uses the ZetaView from Particle Metrix to quantify extracellular vesicles such as exosomes April 28th, 2016

Announcements

Nanoparticles present sustainable way to grow food crops May 1st, 2016

Clay nanotube-biopolymer composite scaffolds for tissue engineering May 1st, 2016

Cooling graphene-based film close to pilot-scale production April 30th, 2016

Personal cooling units on the horizon April 29th, 2016

Homeland Security

Team builds first quantum cascade laser on silicon: Eliminates the need for an external light source for mid-infrared silicon photonic devices or photonic circuits April 21st, 2016

Nanoporous material's strange "breathing" behavior April 7th, 2016

Sniffing out a dangerous vapor: University of Utah engineers develop material that can sense fuel leaks and fuel-based explosives March 28th, 2016

Detecting and identifying explosives with single test December 10th, 2015

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Brookhaven's Oleg Gang Named a Battelle 'Inventor of the Year': Recognized for work using DNA to guide and regulate the self-assembly of nanoparticles into clusters and arrays with controllable properties April 25th, 2016

Zip software can detect the quantum-classical boundary: Compression of experimental data reveals the presence of quantum correlations April 21st, 2016

Making electronics out of coal: Instead of burning up this complex hydrocarbon, let's make devices from it April 20th, 2016

Nano-magnets produce 3-dimensional images: Wide-view 3-dimensional holographic display composed of nano-magnetic pixels April 20th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic