Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Oligonucleotides Create Versatile Coating for Nanoscale Imaging Agents

Abstract:
Nanoparticles made of metals such as gold or iron oxide show tremendous promise as contrast agents for molecular imaging, but turning promise into clinical utility requires adding tumor targeting molecules to the surfaces of these nanoparticles. A new coating technique that uses oligonucleotides to tether targeting molecules securely to a nanoparticle's surface could provide a versatile method for creating such targeted nanoparticles.

Oligonucleotides Create Versatile Coating for Nanoscale Imaging Agents

Bethesda , MD | Posted on November 7th, 2007

Reporting their work in the journal Bioconjugate Chemistry, Rebecca Richards-Kortum, Ph.D., and colleagues describe a method for using sulfur-containing derivatives of DNA that bind tightly to the surface of gold nanoparticles. The researchers then use a complementary DNA sequence to link the DNA-coated nanoparticle to a targeting ligand. The resulting oligonucleotide-linked nanoparticles are much smaller than similar imaging agents constructed by absorbing targeting proteins directly onto the surfaces of gold nanoparticles. The oligonucleotide tethers also produce a construct that is more stable under physiological conditions.

Using their new methodology, the investigators created imaging agents designed to detect the epidermal growth factor receptor (EGF) using either an EGF peptide or an antibody that binds to the receptor. The researchers also created a contrast agent designed to recognize the folate receptor that is overexpressed in many tumors, as well as a contrast agent that also contains a fluorescent marker that allows for multimodal imaging using both confocal reflectance imaging and standard fluoresence imaging. In each case, the contrast agents provided a significant signal boost that was detected easily using the appropriate imaging technique.

This work is detailed in the paper "Oligonucleotide-coated metallic nanoparticles as a flexible platform for molecular imaging agents." This paper was published online in advance of print publication. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
E-mail:

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Nanobiotix Provides Update on Global Development of Lead Product NBTXR3: Seven clinical trials across the world: More than 2/3 of STS patients recruited in the “act.in.sarc” Phase II/III trial: Phase I/II prostate cancer trial now recruiting in the U.S. November 28th, 2016

From champagne bubbles, dance parties and disease to new nanomaterials: Understanding nucleation of protein filaments might help with Alzheimer's Disease and type 2 Diabetes November 24th, 2016

Nanopolymer-modified protein array can pinpoint hard-to-find cancer biomarker November 17th, 2016

Nanotechnology Treatment Found to Inhibit Mesothelioma Tumor Growth November 16th, 2016

Discoveries

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

Announcements

Research Study: MetaSOLTM Shatters Solar Panel Efficiency Forecasts with Innovative New Coating: Coating Provides 1.2 Percent Absolute Enhancement to Triple Junction Solar Cells December 2nd, 2016

Deep insights from surface reactions: Researchers use Stampede supercomputer to study new chemical sensing methods, desalination and bacterial energy production December 2nd, 2016

Quantum obstacle course changes material from superconductor to insulator December 1st, 2016

Throwing new light on printed organic solar cells December 1st, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project