Nanotechnology Now







Heifer International

Wikipedia Affiliate Button


DHgate

Home > Press > Oligonucleotides Create Versatile Coating for Nanoscale Imaging Agents

Abstract:
Nanoparticles made of metals such as gold or iron oxide show tremendous promise as contrast agents for molecular imaging, but turning promise into clinical utility requires adding tumor targeting molecules to the surfaces of these nanoparticles. A new coating technique that uses oligonucleotides to tether targeting molecules securely to a nanoparticle's surface could provide a versatile method for creating such targeted nanoparticles.

Oligonucleotides Create Versatile Coating for Nanoscale Imaging Agents

Bethesda , MD | Posted on November 7th, 2007

Reporting their work in the journal Bioconjugate Chemistry, Rebecca Richards-Kortum, Ph.D., and colleagues describe a method for using sulfur-containing derivatives of DNA that bind tightly to the surface of gold nanoparticles. The researchers then use a complementary DNA sequence to link the DNA-coated nanoparticle to a targeting ligand. The resulting oligonucleotide-linked nanoparticles are much smaller than similar imaging agents constructed by absorbing targeting proteins directly onto the surfaces of gold nanoparticles. The oligonucleotide tethers also produce a construct that is more stable under physiological conditions.

Using their new methodology, the investigators created imaging agents designed to detect the epidermal growth factor receptor (EGF) using either an EGF peptide or an antibody that binds to the receptor. The researchers also created a contrast agent designed to recognize the folate receptor that is overexpressed in many tumors, as well as a contrast agent that also contains a fluorescent marker that allows for multimodal imaging using both confocal reflectance imaging and standard fluoresence imaging. In each case, the contrast agents provided a significant signal boost that was detected easily using the appropriate imaging technique.

This work is detailed in the paper "Oligonucleotide-coated metallic nanoparticles as a flexible platform for molecular imaging agents." This paper was published online in advance of print publication. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580
E-mail:

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Untangling DNA with a droplet of water, a pipet and a polymer: With the 'rolling droplet technique,' a DNA-injected water droplet rolls like a ball over a platelet, sticking the DNA to the plate surface February 27th, 2015

Graphene shows potential as novel anti-cancer therapeutic strategy: University of Manchester scientists have used graphene to target and neutralise cancer stem cells while not harming other cells February 26th, 2015

Discoveries

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

First detailed microscopy evidence of bacteria at the lower size limit of life: Berkeley Lab research provides comprehensive description of ultra-small bacteria February 28th, 2015

Moving molecule writes letters: Caging of molecules allows investigation of equilibrium thermodynamics February 27th, 2015

Announcements

Graphene Shows Promise In Eradication Of Stem Cancer Cells March 1st, 2015

Novel Method to Determine Optical Purity of Drug Components March 1st, 2015

Scientific breakthrough in rechargeable batteries: Researchers from Singapore and Québec Team Up to Develop Next-Generation Materials to Power Electronic Devices and Electric Vehicles February 28th, 2015

First detailed microscopy evidence of bacteria at the lower size limit of life: Berkeley Lab research provides comprehensive description of ultra-small bacteria February 28th, 2015

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More










ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2015 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE