Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > $1.1 million NSF grant to fund research in advanced light microscopy at UCLA

Abstract:
The National Science Foundation has awarded a $1.1 million Major Research Instrumentation grant for the Advanced Light Microscopy core laboratory at the California NanoSystems Institute at UCLA. The award will facilitate the acquisition of the first commercially available super-resolution stimulated emission depletion (STED) confocal laser scanning microscope for nanoscopic resolution of biological samples.

$1.1 million NSF grant to fund research in advanced light microscopy at UCLA

LOS ANGELES, CA | Posted on November 3rd, 2007

The device will be used by a multidisciplinary research team with expertise in physics, chemistry, imaging, genetics and molecular biology led by principal investigator Shimon Weiss, UCLA professor of chemistry and biochemistry, and co-principal investigators Michael Grunstein, UCLA professor of biological chemistry, and Dr. Laurent Bentolila, UCLA senior researcher in chemistry and biochemistry. The team will collaborate with Stefan W. Hell, director of the Max Planck Institute for Biophysical Chemistry in Germany.

Researchers will use the microscope to investigate molecular assemblies at the nanoscale — including deciphering the structure of chromatin and its packaging into chromosomes in the cell —and to study cell signaling, viral and bacterial infection pathways, neural plasticity and many other important biological questions. They will also develop a new family of STED probes based on semiconductor nanocrystals.

"We have assembled a group of multidisciplinary UCLA users who will significantly advance their research by making use of this instrument," said Weiss, who is also a member of the California NanoSystems Institute (CNSI) at UCLA.

Developed by Leica Microsystems, the microscope is uniquely designed for nanoscopic resolution of biological and artificial samples. Despite using regular lenses and visible light, the microscope is not limited by diffraction and diplays a x10 resolution improvement over conventional light microscopes.

STED microscopy provides an alternative to electron microscopy because it capitalizes on the well-established advantages of fluorescence microscopy — including sensitivity, molecular specificity, genetically encoded probes, live cells and ease of operation.

The STED concept relies on stimulated emission, coupled with smart optics, to sharpen the confocal excitation spot, resulting in more detailed, nanometer-resolved images. Bridging the gap between electron and diffraction-limited light microscopy, the STED microscope promises to be a powerful tool for unraveling the relationship between structure and function in cell biology.

The CNSI Advanced Light Microscopy/Spectroscopy shared facility currently provides training to more than 250 research students at the undergraduate, graduate and postdoctoral levels. The new microscope will be used in the education and training of students and researchers through a series of courses offered by the facility. The instrument will also be made available to a large network of researchers throughout Southern California and the United States.

Super-resolution STED microscopy holds great promise because it is expected to lead to significant new discoveries across the fields of biology, chemistry, materials sciences, engineering, medicine and physics.

"Super-resolution fluorescence microscopy will be decisive in solving long-lasting fundamental scientific questions which lie in this intermediate scale of tens of nanometers," said Bentolila, director of the Advanced Light Microscopy core lab at the CNSI.

Leica Microsystems is a leading global designer and producer of innovative high-tech precision optics systems for the analysis of microstructures. It is a market leader in the fields microscopy, confocal laser scanning microscopy, imaging systems, specimen preparation and medical equipment. The company manufactures a broad range of products for numerous applications requiring microscopic imaging, measurement and analysis. It also offers system solutions in the areas of biotechnology and medicine, as well as in the science of raw materials and industrial quality assurance. Comprising nine manufacturing facilities in seven countries, sales and service companies in 20 countries, and an international network of dealers, the company is represented in more than 100 countries. Its international headquarters are in Wetzlar, Germany.

The California NanoSystems Institute is a multidisciplinary research center at UCLA whose mission is to encourage university-industry collaboration and enable the rapid commercialization of discoveries in nanosystems. CNSI members include some of the world's preeminent scientists, and the work conducted at the institute represents world-class expertise in five targeted areas of nanosystems-related research: renewable energy; environmental nanotechnology and nanotoxicology; nanobiotechnology and biomaterials; nanomechanical and nanofluidic systems; and nanoelectronics, photonics and architectonics. For additional information on the institute, visit http://www.cnsi.ucla.edu .

####

About University of California - Los Angeles
UCLA is California's largest university, with an enrollment of nearly 37,000 undergraduate and graduate students. The UCLA College of Letters and Science and the university's 11 professional schools feature renowned faculty and offer more than 300 degree programs and majors. UCLA is a national and international leader in the breadth and quality of its academic, research, health care, cultural, continuing education and athletic programs. Four alumni and five faculty have been awarded the Nobel Prize.

For more information, please click here

Contacts:
Jennifer Marcus

310-267-4839

Copyright © University of California - Los Angeles

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Govt.-Legislation/Regulation/Funding/Policy

Secure Computing for the ‘Everyman': Quantum computing goes to market in tech transfer agreement with Allied Minds September 2nd, 2014

Cool Calculations for Cold Atoms: New theory of universal three-body encounters September 2nd, 2014

UO-Berkeley Lab unveil new nano-sized synthetic scaffolding technique: Oil-and-water approach from Richmond's UO lab to spark new line of versatile peptoid nanosheets September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Announcements

New synthesis method may shape future of nanostructures, clean energy: Findings advance efficient solar spliting of water into hydrogen fuel September 2nd, 2014

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Engineers develop new sensor to detect tiny individual nanoparticles September 2nd, 2014

Future solar panels September 2nd, 2014

Tools

Accounting for Biological Aggregation in Heating and Imaging of Magnetic Nanoparticles September 2nd, 2014

Raman Whispering Gallery Detects Nanoparticles September 1st, 2014

New analytical technology reveals 'nanomechanical' surface traits August 29th, 2014

Ultra-Low Frequency Vibration Isolation Stabilizes Scanning Tunneling Microscopy at UCLA’s Nano-Research Group August 28th, 2014

Grants/Awards/Scholarships/Gifts/Contests/Honors/Records

Rice physicist emerges as leader in quantum materials research: Nevidomskyy wins both NSF CAREER Award and Cottrell Scholar Award August 20th, 2014

Oxford Instruments Asylum Research Receives the 2014 Microscopy Today Innovation Award for blueDrive Photothermal Excitation August 18th, 2014

AQUANOVA receives Technology Leadership Award 2014 FROST & SULLIVAN honors NovaSOL® Technology again August 12th, 2014

Focal blood-brain-barrier disruption with high-frequency pulsed electric fields August 12th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE