Nanotechnology Now

Our NanoNews Digest Sponsors


Heifer International

Wikipedia Affiliate Button

Home > Press > New Hope for Patients Suffering from Degenerative, Inflammatory Eye Diseases

Abstract:
TheraKine and Capsulution Start Joint Development

New Hope for Patients Suffering from Degenerative, Inflammatory Eye Diseases

Berlin, Germany | Posted on October 1st, 2007

Capsulution NanoScience AG, a Berlin-based company, and TheraKine Ltd., an Irish company with significant operations in the United States, are establishing a joint project for the treatment of serious eye diseases. Their aim is to develop an innovative drug-delivery system for ophthalmic applications which will enable local sustained release of one or multiple anti-inflammatory and anti-proliferative biologic and small molecule compounds. This will allow the therapy of difficult to treat eye diseases such as uveitis, diabetic retinopathy and age-related macular degeneration (AMD).

The current treatment possibilities for inflammation of the eye are more than unsatisfactory. Steroids and immunosuppressants have many severe side effects and limited efficacy. Biologic compounds need regularly repeated intravenously or intravitreal injections at relatively high doses. When administered systemically, only traces of the compound reach the interior of the eye, but cause undesirable side effects due to high levels of the compound in other parts of the body. Intravitreal injections offer a solution to this; but currently these still require repeated injections and are limited to a small number of anti-VEGF drugs or long acting steroids. Only a small fraction of patients can be treated with current technology, and there are significant side effects such as internal bleeding, cataracts, retinal damage, increase of pressure inside the eye, and infection.

With the aid of Capsulution's formulation technology, TheraKine will bring an innovative drug-delivery system to the market. "We selected Capsulution because they have the right IP, skilled staff, and an entrepreneurial spirit.", explains TheraKine's CEO Scott Hampton. The collaboration with the internationally-renowned developer of nanocomplexes offers a promising advance towards the formulation of very easily degradable, water-soluble biologic compounds in combination with water-insoluble anti-inflammatory compounds or small molecules. According to Capsulution's Project CSO, Dr. Voigt: "For this application, controlled and sustained release of a pre-defined amount of compound is required." The compound depot in the biodegradable implant should, if possible, only be injected into the eye once.

Mr. Hampton declares: "TheraKine's mission is the creation of therapeutic system to improve vision and prevent blindness". He emphasizes the urgency of the situation: "Effective and safe treatments are desperately needed by millions of people who are currently suffering progressive vision loss due to chronic inflammatory and degenerative eye diseases. Our targeted local delivery will offer safety, effectiveness, and affordable treatment costs."

####

About Capsulution NanoScience AG
Capsulution NanoScience AG is a leading nanotechnology company focusing on the development of tailor-made drug delivery systems and other innovative life science products based on tunable nano-sized capsules. The company applies its worldwide-patented so-called LBL-Technology®. Based on their minute size, their functionality and their highly reproducible production process the tunable capsules can be used for a multitude of different applications. Accordingly, the precisely sized capsules can be made to function in a manner to suit the intended application, and can be given the appropriate biochemical, electrical, optical and magnetic properties as required by the customer.

About TheraKine:
TheraKine was founded in 2004 when a widely respected physician
discovered better treatments for children who were rapidly losing
their eyesight due to chronic inflammatory eye disease. Frustrated by
the limitations of existing systemic delivery systems, the TheraKine
team soon decided that a local, targeted approach to delivery would
produce a much more effective and efficient outcome for the patient.
This work continues, with exciting results in feasibility trials.
TheraKine estimates that the first human clinical trials will start
in the fourth quarter of 2009.

For more information, please click here

Contacts:
Herr Dipl.-Kfm. Alexander Herrmann

Telefon: +49 (30) 6706919-129
Fax: +49 (30) 6706919-101
Zuständigkeitsbereich: Chief Financial Officer (CFO)

Herr Jerry Seelig
TheraKine Ltd.

Telefon: +1 (678) 648-4037
Fax: +1 (678) 623-9550
Zuständigkeitsbereich: Senior Business Development

Copyright © Capsulution NanoScience AG

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Scientists test nanoparticle drug delivery in dogs with osteosarcoma July 26th, 2016

The NanoWizard® AFM from JPK is applied for interdisciplinary research at the University of South Australia for applications including smart wound healing and how plants can protect themselves from toxins July 26th, 2016

Accurate design of large icosahedral protein nanocages pushes bioengineering boundaries: Scientists used computational methods to build ten large, two-component, co-assembling icosahedral protein complexes the size of small virus coats July 25th, 2016

New superconducting coil improves MRI performance: UH-led research offers higher resolution, shorter scan time July 23rd, 2016

Announcements

Ageing can drive progress: Population ageing is likely to boost medicine, nanotechnology and robotics, but increase political risks July 27th, 2016

WSU researchers 'watch' crystal structure change in real time: Breakthrough made possible by new Argonne facility July 27th, 2016

Enhancing molecular imaging with light: New technology platform increases spectroscopic resolution by 4 fold July 27th, 2016

New nontoxic process promises larger ultrathin sheets of 2-D nanomaterials July 27th, 2016

Alliances/Trade associations/Partnerships/Distributorships

XEI Scientific Partners with Electron Microscopy Sciences to Promote and Sell its Products in North and South America July 25th, 2016

Leti and Korea Institute of Science and Technology to Explore Collaboration on Advanced Technologies for Digital Era July 14th, 2016

Nanosystem and Digital Surf launch NanoMap Alpha: New surface imaging & metrology software based on Mountains® Technology July 14th, 2016

FEI and King Abdullah University of Science and Technology Establish New Electron Microscopy ‘Centre of Excellence’: Centre of Excellence involves materials and life sciences research and technical collaboration July 5th, 2016

Research partnerships

New lithium-oxygen battery greatly improves energy efficiency, longevity: New chemistry could overcome key drawbacks of lithium-air batteries July 26th, 2016

Ultrasensitive sensor using N-doped graphene July 26th, 2016

Quantum drag:University of Iowa physicist says current in one iron magnetic sheet can create quantized spin waves in another, separate sheet July 22nd, 2016

Rice's 'antenna-reactor' catalysts offer best of both worlds: Technology marries light-harvesting nanoantennas to high-reaction-rate catalysts July 18th, 2016

NanoNews-Digest
The latest news from around the world, FREE




  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







Car Brands
Buy website traffic