Nanotechnology Now

Our NanoNews Digest Sponsors



Heifer International

Wikipedia Affiliate Button


android tablet pc

Home > Press > PET Scanning Tracks Injected Quantum Dots

Abstract:
A wide variety of experiments have shown that nanoscale quantum dots have the potential to detect early-stage cancer and even monitor the progress of anticancer therapies. But a new study from a team of investigators at the Center for Cancer Nanotechnology Excellence Focused (CCNE) on Therapy Response suggests that quantum dots as they currently exist may not remain in the body long enough to prove useful in human clinical applications.

PET Scanning Tracks Injected Quantum Dots

Bethesda, MD | Posted on September 27th, 2007

Sanjiv Gambhir, M.D., Ph.D., principal investigator of the Stanford University-based CCNE, along with fellow CCNE investigators Anna Wu, Ph.D., and Xiaoyuan Chen, Ph.D., used positron emission tomography (PET) to track the fate of radioactively labeled quantum dots labeled after injection into mice. After injection, PET imaging revealed that as much as a half of the quantum dots were removed from the blood stream by the liver and spleen and that the entire dose was removed from circulation within 10 minutes of injection. Quantum dots coated with poly(ethylene glycol) (PEG), a biocompatible polymer used to extend the circulating lifetime of many types of nanoparticles, fared little better. The size of the quantum dots also had little effect on blood clearance rates.

The researchers note that while this study raises important biodistribution issues that must be solved if quantum dots are to become a useful clinical tool, it also demonstrates that PET monitoring of radiolabelled nanoparticles can provide rapid, quantitative data on nanoparticle biodistribution. In addition, the real-time nature of PET monitoring allowed the investigators to identify differences in pharmacokinetic properties between PEG-coated and native quantum dots. These differences would not have been spotted using traditional pharmacokinetic assays.

This work, which was supported by the National Cancer Institute's Alliance for Nanotechnology in Cancer, is detailed in the paper, "MicroPET-based biodistribution of quantum dots in living mice." Investigators from the University of California, Los Angeles, School of Medicine also participated in this study. An abstract of this paper is available through PubMed.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanomedicine

Graphene and Amaranthus Superparamagnets: Breakthrough nanoparticles discovery of Indian researcher September 23rd, 2014

New NIH/DOE Grant for Life Science Studies at NSLS-II: Funding will support operation of three powerful experimental stations designed to reveal detailed structures of proteins, viruses, and more September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Discoveries

Graphene and Amaranthus Superparamagnets: Breakthrough nanoparticles discovery of Indian researcher September 23rd, 2014

Southampton scientists grow a new challenger to graphene September 23rd, 2014

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Announcements

Future flexible electronics based on carbon nanotubes: Study in Applied Physics Letters show how to improve nanotube transistor and circuit performance with fluoropolymers September 23rd, 2014

Nanotubes help healing hearts keep the beat: Rice University, Texas Children’s Hospital patch for defects enhances electrical connections between cells September 23rd, 2014

Immune system is key ally in cyberwar against cancer: Rice University study yields new two-step strategy for weakening cancer September 23rd, 2014

Los Alamos Researchers Uncover New Properties in Nanocomposite Oxide Ceramics for Reactor Fuel, Fast-Ion Conductors: Misfit dislocations are key to transport properties across material interfaces September 23rd, 2014

Quantum Dots/Rods

Nano-pea pod model widens electronics applications: A new theoretical model explains how a nanostructure, such as the nano-pea pod, can exhibit localised electrons September 4th, 2014

Interaction between Drug, DNA for Designing Anticancer Drugs Studied in Iran August 17th, 2014

NANOPARTICLES INDIA August 8th, 2014

Researchers create quantum dots with single-atom precision June 30th, 2014

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More














ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project







© Copyright 1999-2014 7th Wave, Inc. All Rights Reserved PRIVACY POLICY :: CONTACT US :: STATS :: SITE MAP :: ADVERTISE