Nanotechnology Now

Our NanoNews Digest Sponsors

Heifer International

Wikipedia Affiliate Button

Home > Press > Carbon Nanotubes Have Room for Multifunctionality

Abstract:
In the quest to turn carbon nanotubes from nanoscale wonder into clinically useful drug and imaging agent delivery agents, researchers have often added polymer coatings to the outside of the nanotubes in order to render them biocompatible. Now, researchers at Stanford University have found that even when coated, carbon nanotubes retain the ability to bind extraordinarily large numbers of drug and imaging agent molecules in a stable yet reversible manner.

Carbon Nanotubes Have Room for Multifunctionality

Bethesda, MD | Posted on September 27th, 2007

Reporting its work in the journal ACS Nano, a research team led by Hongjie Dai, Ph.D., an investigator in the Center for Cancer Nanotechnology Excellence Focused on Therapy Response, showed that polymer-coated single-walled carbon nanotubes spontaneously absorbed the cancer drug doxorubicin onto their surfaces when the drug was added to the nanotubes dissolved in water. The resulting construct contained approximately 50 to 60 percent doxorubicin by weight, far higher than the 8 to 10 percent obtained with either liposomes or dendrimers.

The investigators also found that the carbon nanotubes retained their drug payload when dissolved in normal physiological buffer and blood serum, but that the drug released quickly from the nanotubes in the acidic environment characteristic of the insides of tumor cells. The investigators showed, too, that they could permanently attach tumor-targeting molecules and imaging contrast agents to the nanotubes, raising the possibility of creating multifunctional nanoscale devices that could both detect and treat tumors.

This work, which was supported by the National Cancer Institute's Alliance for Nanotechnology in Cancer, is detailed in the paper, "Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery." An abstract of this paper is available at the journal's Web site.

####

About National Cancer Institute
To help meet the goal of reducing the burden of cancer, the National Cancer Institute (NCI), part of the National Institutes of Health, is engaged in efforts to harness the power of nanotechnology to radically change the way we diagnose, treat and prevent cancer.

The NCI Alliance for Nanotechnology in Cancer is a comprehensive, systematized initiative encompassing the public and private sectors, designed to accelerate the application of the best capabilities of nanotechnology to cancer.

Currently, scientists are limited in their ability to turn promising molecular discoveries into benefits for cancer patients. Nanotechnology can provide the technical power and tools that will enable those developing new diagnostics, therapeutics, and preventives to keep pace with today’s explosion in knowledge.

For more information, please click here

Contacts:
National Cancer Institute
Office of Technology & Industrial Relations
ATTN: NCI Alliance for Nanotechnology in Cancer
Building 31, Room 10A49
31 Center Drive , MSC 2580
Bethesda , MD 20892-2580

Copyright © National Cancer Institute

If you have a comment, please Contact us.

Issuers of news releases, not 7th Wave, Inc. or Nanotechnology Now, are solely responsible for the accuracy of the content.

Bookmark:
Delicious Digg Newsvine Google Yahoo Reddit Magnoliacom Furl Facebook

Related News Press

Nanotubes/Buckyballs/Fullerenes/Nanorods

Nanotube fibers in a jiffy: Rice University lab makes short nanotube samples by hand to dramatically cut production time January 11th, 2018

Touchy nanotubes work better when clean: Rice, Swansea scientists show that decontaminating nanotubes can simplify nanoscale devices January 4th, 2018

Paving the way for a non-electric battery to store solar energy: UMass Amherst scientists say a polymer chain organized like a string of Christmas lights assists energy storage December 22nd, 2017

Nanotubes go with the flow to penetrate brain tissue: Rice University scientists, engineers develop microfluidic devices, microelectrodes for gentle implantation December 19th, 2017

Nanomedicine

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

Discoveries

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers February 15th, 2018

Rutgers-Led Innovation Could Spur Faster, Cheaper, Nano-Based Manufacturing: Scalable and cost-effective manufacturing of thin film devices February 14th, 2018

Understanding brain functions using upconversion nanoparticles: Researchers can now send light deep into the brain to study neural activities February 14th, 2018

Announcements

Photonic chip guides single photons, even when there are bends in the road February 16th, 2018

Arrowhead Receives Regulatory Clearance to Begin Phase 1/2 Study of ARO-HBV for Treatment of Hepatitis B February 15th, 2018

Arrowhead Pharmaceuticals Receives Orphan Drug Designation for ARO-AAT February 15th, 2018

European & Korean Project To Demo World’s First 5G Platform During Winter Games February 15th, 2018

NanoNews-Digest
The latest news from around the world, FREE



  Premium Products
NanoNews-Custom
Only the news you want to read!
 Learn More
NanoTech-Transfer
University Technology Transfer & Patents
 Learn More
NanoStrategies
Full-service, expert consulting
 Learn More











ASP
Nanotechnology Now Featured Books




NNN

The Hunger Project